Development of bacterially resistant polyurethane for coating medical devices

Abstract

Polyurethanes have been widely used in medicine for coating and packaging implantable and other medical devices. Polyether-urethanes, in particular, have superior mechanical properties and are biocompatible, but in common with other medical materials they are susceptible to microbial film formation. In this study, polyether-urethane was end-capped with silver lactate and silver sulfadiazine functional groups to produce a bacterially resistant polymer without sacrificing the useful mechanical properties of the polyether-polyurethane. The silver ions were covalently incorporated into the polymer during chain extension of the prepolymer. The functionalized polymers were structurally characterized by light scattering, electron microscopy, NMR, FTIR and Raman spectroscopy. Mechanical properties, hydrophilicity, in vitro stability and antibacterial action of polymers were also investigated. Results indicate that both silver salts were successfully incorporated into the polymer structure without significant effect on mechanical properties, whilst conferring acceptable bacterial resistance.

Gingival Mesenchymal Stem Cell (GMSC) Delivery System Based on RGD‐Coupled Alginate Hydrogel with Antimicrobial Properties: A Novel Treatment Modality for Peri‐Implantitis

“…As has been previously reported, the antimicrobial activity of silver is dependent on the silver cations, which bind strongly to electron donor groups in biological molecules containing sulfur, oxygen, or nitrogen. 39 The highly reactive ionized silver binds to tissue proteins and produces structural changes in the bacterial cell wall and nuclear membrane, leading to cell distortion and death. 15 Moreover, the binding of silver to bacterial DNA and RNA inhibits bacterial replication.…”

“…33 Many research groups have already explored the association of silver and biomaterials or have attached Ag to the implant itself as a means of preventing bacterial colonization, especially in the initial period after implant placement. [34][35][36][37][38][39] A literature search failed to reveal any reports evaluating the application of GMSCs encapsulated in RGD-coupled alginate microspheres containing antimicrobial agents in bone regenerative therapy for peri-implantitis. Therefore, in the current study, we developed an injectable and 3D RGD-coupled alginate hydrogel cell encapsulation system containing silver lactate (SL).…”

“…To achieve its biocidal effect, the required Ag dose is typically low enough to spare mammalian cell functions . Many research groups have already explored the association of silver and biomaterials or have attached Ag to the implant itself as a means of preventing bacterial colonization, especially in the initial period after implant placement …”

Biopolymer Coatings for Biomedical Applications

“…Bacterial resistance PU coatings for medical devices were developed by Roohpour et al [76]. To inhibit microbial film formation, silver lactate and silver sulfadiazine were capped with the polymer.…”

Effect of hyaluronic acid incorporation method on the stability and biological properties of polyurethane–hyaluronic acid biomaterials

“…Between 1 and 5% of patients develop vascular graft infection, with a mortality rate of up to 50%, depending on the graft site [16,58]. Other groups have modified polyurethanes to impart bactericidal properties via a range of techniques, with inclusion of quaternary ammonium salts [59,60] or silver [61-63] being the predominant approaches. While these polyurethanes have been shown to possess excellent antimicrobial properties, in most cases it is not known how well these properties are maintained following exposure to flow.…”