Development of banana (<i>Musa balbisiana</i>) pseudo stem fiber as a surgical bio-tool to avert post-operative wound infections

Kalita, Himadri; Hazarika, Ankita; Kandimalla, Raghuram; Kalita, Sanjeeb; Devi, Rajlakshmi

doi:10.1039/c8ra04470h

Cited by 18 publications

(7 citation statements)

References 47 publications

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“…In this sense, a pseudo stem banana fiber impregnated with chloramphenicol, clotrimazole and growth factors (hydro-gel system), proved to be biocompatible and comparable to a commercially available suture. This suture inhibited biofilm formation on its surface, contributing to a better wound healing efficacy, with lower microbial burden and inflammatory cytokine levels (H. Kalita, Hazarika, et al, 2018).…”

Section: Bacteriamentioning

confidence: 99%

“…As a substrate for biofilm formation, suture materials also demand novel suture biomaterials, with better characteristics. Banana ( Musa balbisiana Colla) fiber has been explored to produce antimicrobials releasing suture biomaterial (BSc), for the prevention of post‐operative wound infection, having also the advantage of being environment friendly (H. Kalita, Hazarika, Kandimalla, Kalita, & Devi, 2018). In this sense, a pseudo stem banana fiber impregnated with chloramphenicol, clotrimazole and growth factors (hydro‐gel system), proved to be biocompatible and comparable to a commercially available suture.…”

Section: Pharmacological Properties Of Curcumin Nanoformulationsmentioning

confidence: 99%

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Curcumin nanoformulations for antimicrobial and wound healing purposes

Salehi

Rodrigues

Peron

et al. 2021

Phytotherapy Research

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The development and spread of resistance to antimicrobial drugs is hampering the management of microbial infectious and wound healing processes. Curcumin is the most active and effective constituent of Curcuma longa L., also known as turmeric, and has a very long and strong history of medicinal value for human health and skincare. Curcumin has been proposed as strong antimicrobial potentialities and many attempts have been made to determine its ability to conjointly control bacterial growth and promote wound healing. However, low aqueous solubility, poor tissue absorption and short plasma half‐life due its rapid metabolism needs to be solved for made curcumin formulations as suitable treatment for wound healing. New curcumin nanoformulations have been designed to solve the low bioavailability problem of curcumin. Thus, in the present review, the therapeutic applications of curcumin nanoformulations for antimicrobial and wound healing purposes is described.

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Section: Bacteriamentioning

confidence: 99%

Section: Pharmacological Properties Of Curcumin Nanoformulationsmentioning

confidence: 99%

Curcumin nanoformulations for antimicrobial and wound healing purposes

Salehi

Rodrigues

Peron

et al. 2021

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…In addition, 100 μL of samples from each well were spread on a TSB agar plate and cultured overnight to observe colonies. 38 The free-PTM content of the NP-gel(PTM) group was detected by the HPLC method. Similarly, the OD 600 values of the blank NP-gel without PTM were measured at 12 and 18 h. Considering the actual drug loss, half of the medium was replaced with fresh TSB at 3 and 6 h after an initial drug concentration of 1 μg/mL.…”

Section: Methodsmentioning

confidence: 99%

“…After incubation in an incubator at 37 °C for 18 h, the OD 600 value of each well was measured with a microplate reader. In addition, 100 μL of samples from each well were spread on a TSB agar plate and cultured overnight to observe colonies . The free-PTM content of the NP-gel(PTM) group was detected by the HPLC method.…”

Section: Methodsmentioning

confidence: 99%

Nanoparticle-Hydrogel Systems Containing Platensimycin for Local Treatment of Methicillin-Resistant Staphylococcus aureus Infection

et al. 2021

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Skin and soft tissue infections require effective and sustained topical administration. Platensimycin (PTM) is a natural drug lead that targets bacterial fatty acid synthases and has a great potential to treat infections caused by methicillin-resistant Staphylococcus aureus (MRSA). To facilitate the use of PTM against local MRSA infections, we prepared polyacrylamide hydrogels containing polyamidoamine (PAMAM)/PTM nanoparticles (NP-gel(PTM)) for the controlled release of PTM. NP-gel(PTM) can continuously inhibit the growth of MRSA and its biofilm formation in simulated drug flow models in vitro. In situ implantation of NP-gel(PTM) could treat MRSA-infected subcutaneous soft tissues without toxicity. For MRSA-infected skin wounds, NP-gel(PTM) not only showed strong anti-MRSA activity but also accelerated more wound healing than the widely used antibiotic mupirocin. Collectively, PTM is expected to be used in this safe and effective NP-gel delivery platform for the treatment of local infections, which might help to alleviate the current antibiotic resistance crisis.

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“…Nevertheless, there is an increased concern related to multidrug-resistant microorganisms. Worldwide, numerous scientists direct their efforts toward nding new alternatives for combating pathogens [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Precise engineering of ultrasound-mediated cerium oxide nanoparticles: Investigations on antioxidant, antibacterial activity and human osteomyelitis

Dai

Wang

Chen

et al. 2021

Preprint

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In this study, the antibacterial activity of cerium oxide nanoparticles on two Gram-negative and three Gram-positive foodborne pathogens was investigated. CeO2 nanoparticles (CeO2 NPs) were synthesized by a Wet Chemical Synthesis route, using the precipitation method and the Simultaneous Addition of reactants (WCS–SimAdd). The as-obtained precursor powders were investigated by thermal analysis (TG–DTA), to study their decomposition process and to understand the CeO2 NPs formation. The composition, structure, and morphology of the thermally treated sample were investigated by FTIR, Raman spectroscopy, X-ray diffraction, TEM, and DLS. The cubic structure and average particle size ranging between 5 and 15 nm were evidenced. Optical absorption measurements (UV–Vis) reveal that the band gap of CeO2 NPs is 2.61 eV, which is smaller than the band gap of bulk ceria. The antioxidant effect of CeO2 NPs was determined, and the antibacterial test was carried out both in liquid and on solid growth media against five pathogenic microorganisms, namely Escherichia coli, Salmonella typhimurium, Listeria monocytogenes, Staphylococcus aureus, and Bacillus cereus. Cerium oxide nanoparticles showed growth inhibition toward all five pathogens tested with notable results. This paper highlights the CeO2 NPs showed antibacterial activity with significant variations due to the differences in the membrane structure and cell wall composition among the two groups tested. Consequently, synthesized CeO2 NPs can be potential candidates for the treatment of osteomyelitis.

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Development of banana (Musa balbisiana) pseudo stem fiber as a surgical bio-tool to avert post-operative wound infections

Abstract: A novel antimicrobial suture biomaterial developed from banana waste fibers to avert post operative wound infections.

Cited by 18 publications

References 47 publications

Curcumin nanoformulations for antimicrobial and wound healing purposes

Curcumin nanoformulations for antimicrobial and wound healing purposes

Nanoparticle-Hydrogel Systems Containing Platensimycin for Local Treatment of Methicillin-Resistant Staphylococcus aureus Infection

Precise engineering of ultrasound-mediated cerium oxide nanoparticles: Investigations on antioxidant, antibacterial activity and human osteomyelitis

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