Development of barley and yeast β-glucan aerogels for drug delivery by supercritical fluids

Salgado, Marta; Santos, Filipa; Rodríguez‐Rojo, Soraya; Reis, Rui L.; Duarte, Ana Rita C.; Cocero, Marı́a José

doi:10.1016/j.jcou.2017.10.006

Cited by 56 publications

(19 citation statements)

References 51 publications

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“…The properties of CNF aerogels such as their biodegradability, biocompatibility, low toxicity and renewability have had an impact on the prospects of aerogels in a wide range of biological and medical applications under investigation ( Table 4 ). CNF aerogel has been tested in diverse medical applications such as biosensing, tissue engineering [ 94 ] and drug delivery [ 95 ].…”

Section: Cellulose Nanofibre (Cnf) Aerogels In Medical Applicationmentioning

confidence: 99%

A Review on Plant Cellulose Nanofibre-Based Aerogels for Biomedical Applications

et al. 2020

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Cellulose nanomaterials from plant fibre provide various potential applications (i.e., biomedical, automotive, packaging, etc.). The biomedical application of nanocellulose isolated from plant fibre, which is a carbohydrate-based source, is very viable in the 21st century. The essential characteristics of plant fibre-based nanocellulose, which include its molecular, tensile and mechanical properties, as well as its biodegradability potential, have been widely explored for functional materials in the preparation of aerogel. Plant cellulose nano fibre (CNF)-based aerogels are novel functional materials that have attracted remarkable interest. In recent years, CNF aerogel has been extensively used in the biomedical field due to its biocompatibility, renewability and biodegradability. The effective surface area of CNFs influences broad applications in biological and medical studies such as sustainable antibiotic delivery for wound healing, the preparation of scaffolds for tissue cultures, the development of drug delivery systems, biosensing and an antimicrobial film for wound healing. Many researchers have a growing interest in using CNF-based aerogels in the mentioned applications. The application of cellulose-based materials is widely reported in the literature. However, only a few studies discuss the potential of cellulose nanofibre aerogel in detail. The potential applications of CNF aerogel include composites, organic–inorganic hybrids, gels, foams, aerogels/xerogels, coatings and nano-paper, bioactive and wound dressing materials and bioconversion. The potential applications of CNF have rarely been a subject of extensive review. Thus, extensive studies to develop materials with cheaper and better properties, high prospects and effectiveness for many applications are the focus of the present work. The present review focuses on the evolution of aerogels via characterisation studies on the isolation of CNF-based aerogels. The study concludes with a description of the potential and challenges of developing sustainable materials for biomedical applications.

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Section: Cellulose Nanofibre (Cnf) Aerogels In Medical Applicationmentioning

confidence: 99%

A Review on Plant Cellulose Nanofibre-Based Aerogels for Biomedical Applications

et al. 2020

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“…These aerogel-based microparticles displayed significantly enhanced drug release properties. Salgado et al 90 produced barley and yeast β-glucans aerogels by a gelation process in aqueous solution, followed by solvent exchange and drying with supercritical CO 2 , which were used for acetylsalicylic acid loading and release. Lopez-Iglesias et al 49 reported chitosan-based aerogel beads with a fibrous structure, which showed high porosity (>96%) and large surface area (>200 m 2 /g).…”

Section: Aerogel-based Biomaterials For Drug Deliverymentioning

confidence: 99%

<p>Engineering of Aerogel-Based Biomaterials for Biomedical Applications</p>

Zheng¹,

Zhang²,

Ying³

et al. 2020

IJN

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Biomaterials with porous structure and high surface area attract growing interest in biomedical research and applications. Aerogel-based biomaterials, as highly porous materials that are made from different sources of macromolecules, inorganic materials, and composites, mimic the structures of the biological extracellular matrix (ECM), which is a three-dimensional network of natural macromolecules (e.g., collagen and glycoproteins), and provide structural support and exert biochemical effects to surrounding cells in tissues. In recent years, the higher requirements on biomaterials significantly promote the design and development of aerogel-based biomaterials with high biocompatibility and biological activity. These biomaterials with multilevel hierarchical structures display excellent biological functions by promoting cell adhesion, proliferation, and differentiation, which are critical for biomedical applications. This review highlights and discusses the recent progress in the preparation of aerogel-based biomaterials and their biomedical applications, including wound healing, bone regeneration, and drug delivery. Moreover, the current review provides different strategies for modulating the biological performance of aerogel-based biomaterials and further sheds light on the current status of these materials in biomedical research.

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“…Hydrogels of two beta-glucans were dried with scCO2 to produce aerogels for tissue engineering purposes. These aerogels were loaded with acetylsalicylic acid [ 107 ] or with dexamethasone [ 108 ]. High water uptakes were obtained for both glucans (between 600% and 1400%, depending on the concentration and glucan type).…”

Section: Exopolysaccharides For Producing Ddssmentioning

confidence: 99%

“…These differences in water uptake promoted a different sustained drug release over 24 h. Since their specific surface areas were always higher than 100 m 2 ·g −1 , this article demonstrates the possibility of producing aerogels via scCO 2 drying. However, the Young´s modulus of the obtained aerogels was between 8–15 kPa and their application for tissue engineering must be chosen carefully [ 107 , 108 ].…”

Section: Exopolysaccharides For Producing Ddssmentioning

confidence: 99%

Microbial Exopolysaccharides as Drug Carriers

Cardea

2020

Polymers

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Microbial exopolysaccharides are peculiar polymers that are produced by living organisms and protect them against environmental factors. These polymers are industrially recovered from the medium culture after performing a fermentative process. These materials are biocompatible and biodegradable, possessing specific and beneficial properties for biomedical drug delivery systems. They can have antitumor activity, they can produce hydrogels with different characteristics due to their molecular structure and functional groups, and they can even produce nanoparticles via a self-assembly phenomenon. This review studies the potential use of exopolysaccharides as carriers for drug delivery systems, covering their versatility and their vast possibilities to produce particles, fibers, scaffolds, hydrogels, and aerogels with different strategies and methodologies. Moreover, the main properties of exopolysaccharides are explained, providing information to achieve an adequate carrier selection depending on the final application.

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Development of barley and yeast β-glucan aerogels for drug delivery by supercritical fluids

Cited by 56 publications

References 51 publications

A Review on Plant Cellulose Nanofibre-Based Aerogels for Biomedical Applications

A Review on Plant Cellulose Nanofibre-Based Aerogels for Biomedical Applications

<p>Engineering of Aerogel-Based Biomaterials for Biomedical Applications</p>

Microbial Exopolysaccharides as Drug Carriers

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