Development of Batch Crystallizations

Wieckhusen, Dierk

doi:10.1002/9783527650323.ch10

Cited by 10 publications

(18 citation statements)

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“…The reasoning developed here for batch reactors 4,5 extends similarly to other batch units such as batch distillation columns 6,7 and batch crystallizers 8,9 .…”

Section: What To Model?mentioning

confidence: 96%

Control and Optimization of Batch Chemical Processes

Bonvin

François

2017

Coulson and Richardson's Chemical Engineering

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A batch process is characterized by the repetition of time-varying operations of finite duration. Due to the repetition, there are two independent "time" variables, namely, the run time during a batch and the batch index. Accordingly, the control and optimization objectives can be defined for a given batch or over several batches. This chapter describes the various control and optimization strategies available for the operation of batch processes. These include online and run-to-run control on the one hand, and repeated numerical optimization and optimizing control on the other. Several case studies are presented to illustrate the various approaches Keywords Batch control, predictive control, iterative learning control, run-to-run control, batch process optimization, dynamic optimization, optimizing control, run-to-run optimization.

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“…The reasoning developed here for batch reactors 4,5 extends similarly to other batch units such as batch distillation columns 6,7 and batch crystallizers 8,9 .…”

Section: What To Model?mentioning

confidence: 96%

Control and Optimization of Batch Chemical Processes

Bonvin

François

2017

Coulson and Richardson's Chemical Engineering

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“…To separate a target compound from a multi-component mixture, seeded cooling crystallization is preferably applied. Anti-solvent is usually added either at the beginning of the cooling step to generate the supersaturation in the solution or at the end of the process to increase the overall crystallization yield [39].…”

Section: Rawmentioning

confidence: 99%

“…To increase the product yield of the seeded cooling crystallization, it is suitable to conduct anti-solvent addition to the product suspension at the end of the cooling step [39]. In this work, to improve the overall yields of processes 1, 2 and 4 addition of water, 2-propanol and acetonitrile as anti-solvents of CUR in acetone was investigated.…”

Section: Improvement Of the Total Yield By Means Of Anti-solvent Addimentioning

confidence: 99%

Purification of Curcumin from Ternary Extract-Similar Mixtures of Curcuminoids in a Single Crystallization Step

et al. 2020

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Crystallization-based separation of curcumin from ternary mixtures of curcuminoids having compositions comparable to commercial extracts was studied experimentally. Based on solubility and supersolubility data of both, pure curcumin and curcumin in presence of the two major impurities demethoxycurcumin (DMC) and bis(demethoxy)curcumin (BDMC), seeded cooling crystallization procedures were derived using acetone, acetonitrile and 50/50 (wt/wt) mixtures of acetone/2-propanol and acetone/acetonitrile as solvents. Starting from initial curcumin contents of 67–75% in the curcuminoid mixtures single step crystallization processes provided crystalline curcumin free of BDMC at residual DMC contents of 0.6–9.9%. Curcumin at highest purity of 99.4% was obtained from a 50/50 (wt/wt) acetone/2-propanol solution in a single crystallization step. It is demonstrated that the total product yield can be significantly enhanced via addition of water, 2-propanol and acetonitrile as anti-solvents at the end of a cooling crystallization process.

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“…To overcome this issue the usage of seed particles is favorable. These seed particles grow in the metastable zone, the area between the solubility and supersolubility curve without primary nucleation [30][31][32][33]. For the design space of the crystallization step, information on the metastable zone width (MSZW) is necessary.…”

Section: Raw and Purified Materialsmentioning

confidence: 99%

“…Even though seeding strategies prevent primary nucleation, secondary nucleation like breakage or attrition and agglomeration as counterpart affect the particle distribution. These effects are component-specific, and therefore have to be determined for the chosen artemisinin system [24,31]. Artemisinin forms two polymorphs, which means it grows in different crystal shapes.…”

Section: Raw and Purified Materialsmentioning

confidence: 99%

Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L.—Part IV: Crystallization

et al. 2018

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In this study, process integration for crystallization of a priori purified Artemisia annua L. is investigated. For this total process, the integration operation boundaries and behavior of the crystals are studied. This is performed focusing on a conceptual process design study for artemisinin, aiming towards the development of a crystallization step under given parameters by process integration. At first, different crystallization systems consisting of ethanol-water or acetone-water mixtures are compared. In subsequent steps, the metastable zone width and the behavior of the crystals regarding agglomeration and breakage are checked. Furthermore, the sensitivities of process variables based on several process parameters are investigated. Additionally, the final process integration of crystallization as a combined purification and isolation step is studied.

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Development of Batch Crystallizations

Cited by 10 publications

References 0 publications

Control and Optimization of Batch Chemical Processes

Control and Optimization of Batch Chemical Processes

Purification of Curcumin from Ternary Extract-Similar Mixtures of Curcuminoids in a Single Crystallization Step

Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L.—Part IV: Crystallization

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