This paper present an efficient micro-system stimulator to transfer data and power in biomedical implanted device by using Amplitude shift keying (ASK) modulation technique. The proposed system operates with low frequency 6.78MHz accordance to the industrial-scientific-medical (ISM) bands to avoid the biological tissue damage. The system design include new ASK modulator, class-E power amplifier, half wave rectifier, voltage regulator (LDO) and new ASK demodulator structure without passive elements to transfer 500Kb/s of data with modulation index 12.5%. The efficient inductive coupling link with 74.47% of efficiency is driven by class-E power amplifier with high efficiency up to 94.5%. Adequate and stable 1.8V DC are generated by the modified rectifier and voltage regulator to power the implanted electronics which occupies small area and does not have a thermal protection circuit or passive elements. The proposed ASK demodulator structure is developed to collect a synchronised demodulated signal that has minimum error without using delay-locked loops (DLL) circuits and clock recovery circuit. This system designed by using OrCAD Pspice 16.6 software, which employed 0.35 µm CMOS technology as a basis.