Development of biocompatible magnetic microrobot transporter using 3D laser lithography

Li, Junyang; Ma, Weiyin; Niu, Fuzhou; Chow, Y. T.; Chen, Shuxun; Ouyang, Bo; Ji, Haibo; Yang, Jie; Sun, Dong

doi:10.1109/aim.2016.7576856

Cited by 5 publications

(5 citation statements)

References 31 publications

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“…Soft paramagnetic materials, [ 65,90 ] including Ni, [ 17,18,60,61,63,64,83,91,92 ] Fe, [ 65,71,79,93–95 ]

F e_{3} O_{4}

etc., have high permeability and low coercivity so that they can be easily magnetized and demagnetized by external fields. Tottori et al [ 59 ] presented a helical microrobot composed of SU‐8 and IP‐L materials, as shown in Figure 2 A.…”

Section: Materials For Mn‐robotsmentioning

confidence: 99%

“…Afterward, they presented another spherical microrobot swimmer‐coated Ni/Ti layer using the sputtering system. [ 92 ] The structure can be observed at a scan laser power of 30 mW and scan laser speed of 96 μm s −1 . The follow‐up experiment showed that selected materials have no cytotoxic for NIH 3T3 mouse fibroblast cells.…”

Section: Materials For Mn‐robotsmentioning

confidence: 99%

“…Porous mn‐robots have advantages over traditional solid microstructure for cells growth and differentiation. Li et al [ 91 ] designed a porous spherical magnetic microrobot for delivery cells, as shown in Figure 10 A. And, they again showed a burrlike porous spherical microrobot for loading and transporting targeted MC3T3‐E1 fibroblasts and MSCs.…”

Section: Design For Targeted Therapymentioning

confidence: 99%

Section: Design For Targeted Therapymentioning

confidence: 99%

“…In nature, the soft paramagnetic particles, especially iron, exhibit higher saturation magnetization, magnetic susceptibility, and excellent biocompatibility. [79] Soft paramagnetic materials, [65,90] including Ni, [17,18,60,61,63,64,83,91,92] Fe, [65,71,79,[93][94][95] Fe 3 O 4 etc., have high permeability and low coercivity so that they can be easily magnetized and demagnetized by external fields. Tottori et al [59] presented a helical microrobot composed of SU-8 and IP-L materials, as shown in Figure 2A.…”

Section: Functional Materialsmentioning

confidence: 99%

See 4 more Smart Citations

Development of 3D‐Printed Magnetic Micro‐Nanorobots for Targeted Therapeutics: the State of Art

Hu,

Ding,

Liu

et al. 2023

Advanced NanoBiomed Research

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Micro‐/nanorobots (mn‐robots), inspired by the versatile mechanisms found in natural microorganisms, show great potential in enabling innovative bio‐applications. The 3D‐printed magnetic mn‐robots are substantially advanced to swim in vivo and to carry and release therapeutic agents in a controlled manner. To understand the state of the art of such robots and identify their development trend, this article presents a comprehensive and systematic review of the recent works on development of magnetic robots and their applications in biomedical engineering, with a particular focus on targeted therapeutic delivery. The developments in materials, fabrications, actuations, and applications with design for magnetic mn‐robots are reviewed, and it is aimed to discover the limitations of the existing works and to identify the knowledge gap, thereby deriving future research directions on developing magnetic mn‐robots, especially for their applications in targeted therapeutic delivery.

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“…Soft paramagnetic materials, [ 65,90 ] including Ni, [ 17,18,60,61,63,64,83,91,92 ] Fe, [ 65,71,79,93–95 ]

F e_{3} O_{4}

Section: Materials For Mn‐robotsmentioning

confidence: 99%

Section: Materials For Mn‐robotsmentioning

confidence: 99%

Section: Design For Targeted Therapymentioning

confidence: 99%

Section: Design For Targeted Therapymentioning

confidence: 99%

Section: Functional Materialsmentioning

confidence: 99%

See 3 more Smart Citations

Development of 3D‐Printed Magnetic Micro‐Nanorobots for Targeted Therapeutics: the State of Art

Hu,

Ding,

Liu

et al. 2023

Advanced NanoBiomed Research

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Magnet‐Driven Microwalker in Surface Motion Based on Frictional Anisotropy

Jia

Pan

Wang

et al. 2022

Advanced Intelligent Systems

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Untethered magnet‐driven microrobots play an increasingly important role in various biomedical applications. Incorporating bionic technology into microrobot design is an emerging way to improve the work efficiency of microrobots. Herein, a magnetically powered and frictional anisotropy‐based microwalker that can be potentially used in in vivo nonliquid‐filled environment is proposed. The microwalker is constructed by two rigid segments with an equal length of 70 μm, connected by a rigid joint. Parallel gecko setae‐like tentacles are placed at the bottom of the segments as contact feet to generate friction with the contact surface. The microwalker is integrally fabricated from biocompatible materials with 3D laser lithography based on two‐photon polymerization. The microwalker can be well controlled to move in low‐Reynolds (Re)‐number regimes under an external oscillating magnetic field. In addition to moving in a liquid environment as existing microswimmers, the microwalker can move in surface in a nonliquid‐filled environment. It can also climb the slope driven by the planar magnetic field only. Several experiments were conducted to demonstrate good motion capability of the microwalker. This study provides a new solution to microrobot design for future biomedical applications.

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Magnetically Driven Undulatory Microswimmers Integrating Multiple Rigid Segments

Pan

Liang

Sun

2019

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Mimicking biological locomotion strategies offers important possibilities and motivations for robot design and control methods. Among bioinspired microrobots, flexible microrobots exhibit remarkable efficiency and agility. These microrobots traditionally rely on soft material components to achieve undulatory propulsion, which may encounter challenges in design and manufacture including the complex fabrication processes and the interfacing of rigid and soft components. Herein, a bioinspired magnetically driven microswimmer that mimics the undulatory propulsive mechanism is proposed. The designed microswimmer consists of four rigid segments, and each segment is connected to the succeeding segment by joints. The microswimmer is fabricated integrally by 3D laser lithography without further assembly, thereby simplifying microrobot fabrication while enhancing structural integrity. Experimental results show that the microswimmer can successfully swim forward along guided directions via undulatory locomotion in the low Reynolds number (Re) regime. This work demonstrates for the first time that the flexible characteristic of microswimmers can be emulated by 3D structures with multiple rigid segments, which broadens possibilities in microrobot design. The proposed magnetically driven microswimmer can potentially be used in biomedical applications, such as medical diagnosis and treatment in precision medicine.

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Development of biocompatible magnetic microrobot transporter using 3D laser lithography

Cited by 5 publications

References 31 publications

Development of 3D‐Printed Magnetic Micro‐Nanorobots for Targeted Therapeutics: the State of Art

Development of 3D‐Printed Magnetic Micro‐Nanorobots for Targeted Therapeutics: the State of Art

Magnet‐Driven Microwalker in Surface Motion Based on Frictional Anisotropy

Magnetically Driven Undulatory Microswimmers Integrating Multiple Rigid Segments

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