Development of biodegradable scaffolds based on patient-specific arterial configuration

Uchida, Tomoyuki; Ikeda, Seiichi; Oura, Hiroyuki; Tada, Mika; Nakano, Takuma; Fukuda, Toshio; Matsuda, Takehisa; Negoro, Makoto; Arai, Fumihito

doi:10.1016/j.jbiotec.2007.08.017

Cited by 60 publications

(21 citation statements)

References 27 publications

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“…Their mechanical strength was 323 MPa (tensile modulus) and about 100 times of that of natural blood vessel in human. 19,20 Therefore this type of PLGA blood vessel was sufficient for implantation through surgical treatment in animal model. In vitro Cell Adhesion.…”

Section: Resultsmentioning

confidence: 98%

In vitro andin vivo application of PLGA nanofiber for artificial blood vessel

Kim

et al. 2008

Macromol. Res.

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Poly(lactic-co-glycolic acid) (PLGA) tubes (5 mm in diameter) were fabricated using an electro spinning method and used as a scaffold for artificial blood vessels through the hybridization of smooth muscle cells (SMCs) and endothelial cells (ECs) differentiated from canine bone marrow under previously reported conditions. The potential clinical applications of these artificial blood vessels were investigated using a canine model. From the results, the tubular-type PLGA scaffolds for artificial blood vessels showed good mechanical strength, and the duallayered blood vessels showed acceptable hybridization behavior with ECs and SMCs. The artificial blood vessels were implanted and substituted for an artery in an adult dog over a 3-week period. The hybridized blood vessels showed neointimal formation with good patency. However, the control vessel (unhybridized vessel) was occluded during the early stages of implantation. These results suggest a shortcut for the development of small diameter, tubular-type, nanofiber blood vessels using a biodegradable material (PLGA).

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Section: Resultsmentioning

confidence: 98%

In vitro andin vivo application of PLGA nanofiber for artificial blood vessel

Kim

et al. 2008

Macromol. Res.

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“…pore size and interconnected porosity) [5,6]. It has been shown that 3D porous scaffolds, reproducing the shape of the patient's bone defect, have a great biocompatibility after the surgical procedure [7,8].…”

Section: Introductionmentioning

confidence: 99%

Direct-write assembly of 3D scaffolds using colloidal calcium phosphates inks

et al. 2014

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Additive manufacture techniques using concentrated colloidal inks are a promising approach for creating three-dimensional (3D) calcium phosphates scaffolds for bone repair and regeneration. Among those, the direct-write assembly allows building scaffolds with precise size and geometry. In the present work, commercial β-TCP and HA were used to produce two types of colloidal ink. According to the ink composition used to build the scaffolds, two different groups were obtained. Group I: scaffolds produced with β-TCP-based ink; and Group II: scaffolds produced with biphasic CaP-based ink (BCP). The 3D scaffolds were assembled in a cylindrical shape (Φ = 8mm x H= 16 mm) with interconnected pore channels of approximately 500μm by robotic deposition of 64 layers using a robocasting machine. The mechanical compression property of the scaffolds was determined using universal testing machine. To assure the controlled geometry of the scaffolds, digital images were obtained by reconstructing each individual scan obtained with a micro-computed tomography. An optical contact angle measurement system was used to evaluate the wettability of the materials. After analyzing the results it was concluded that: the robocasting system is suitable for building 3D periodic calcium phosphates scaffolds; the direct-write assembly didn't change the hydrophilic characteristic of CaPs; and presented mean compressive strength around 11 MPa (β-TCP group) and 15 MPa (BCP group), which is compatible with trabecular bone.

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“…Since there are individual variations among patients and differences in damaged parts, bone tissue engineering scaffolds need to be custom-made to meet individual patient needs. Fabricating scaffolds precisely according to the 3D shape of the patient's bone defects will also improve the biocompatibility of scaffolds following implantation (Uchida et al, 2008). Although various attempts have been made to fabricate scaffolds according to the shape of patient bone defects (Dyson et al, 2007;Hollister et al, 2000;Sanz-Herrera and Garcia-Aznar, 2009;Wang et al, 2009;Wettergreen et al, 2005), scaffolds have not been formulated that truly reproduce patient-specific bone defects.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of individual scaffolds based on a patient-specific alveolar bone defect model

Zhang

et al. 2011

Journal of Biotechnology

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Development of biodegradable scaffolds based on patient-specific arterial configuration

Cited by 60 publications

References 27 publications

In vitro andin vivo application of PLGA nanofiber for artificial blood vessel

In vitro andin vivo application of PLGA nanofiber for artificial blood vessel

Direct-write assembly of 3D scaffolds using colloidal calcium phosphates inks

Fabrication of individual scaffolds based on a patient-specific alveolar bone defect model

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