Development of biomass waste-based carbon quantum dots and their potential application as non-toxic bioimaging agents

Abu, Norhidayah; Chinnathambi, Shanmugavel; Kumar, Mahima; Etezadi, Fatemeh; Bakhori, Noremylia Mohd; Zubir, Zuhana Ahmad; Md Salleh, Shahrul Nizam; Shueb, Rafidah Hanim; Karthikeyan, Subramani; Thangavel, Vaijayanthi; Abdullah, Jaafar; Pandian, Ganesh N.

doi:10.1039/d3ra05840a

Cited by 17 publications

(2 citation statements)

References 73 publications

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“…Therefore, exploring alternative production methods that could mitigate these issues and allow for the safe and effective use of QDs in clinical studies, bioimaging, drug delivery, and other such applications becomes essential. The advantages of CQDs, such as low cytotoxicity, favorable biocompatibility, high solubility, low cost, and chemical inertness, coupled with their similar fluorescence properties to semiconductor QDs, have made them a promising alternative 9 . As a result, CQDs exhibit the required potential to replace the semiconductor QDs.…”

Section: Introductionmentioning

confidence: 99%

Biomass-derived carbon dots as fluorescent quantum probes to visualize and modulate inflammation

Kumar,

Chinnathambi,

Bakhori

et al. 2024

Sci Rep

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Quantum dots, which won the Nobel Prize in Chemistry, have recently gained significant attention in precision medicine due to their unique properties, such as size-tunable emission, high photostability, efficient light absorption, and vibrant luminescence. Consequently, there is a growing demand to identify new types of quantum dots from various sources and explore their potential applications as stimuli-responsive biosensors, biomolecular imaging probes, and targeted drug delivery agents. Biomass-waste-derived carbon quantum dots (CQDs) are an attractive alternative to conventional QDs, which often require expensive and toxic precursors, as they offer several merits in eco-friendly synthesis, preparation from renewable sources, and cost-effective production. In this study, we evaluated three CQDs derived from biomass waste for their potential application as non-toxic bioimaging agents in various cell lines, including human dermal fibroblasts, HeLa, cardiomyocytes, induced pluripotent stem cells, and an in-vivo medaka fish (Oryzias latipes) model. Confocal microscopic studies revealed that CQDs could assist in visualizing inflammatory processes in the cells, as they were taken up more by cells treated with tumor necrosis factor-α than untreated cells. In addition, our quantitative real-time PCR gene expression analysis has revealed that citric acid-based CQDs can potentially reduce inflammatory markers such as Interleukin-6. Our studies suggest that CQDs have potential as theragnostic agents, which can simultaneously identify and modulate inflammatory markers and may lead to targeted therapy for immune system-associated diseases.

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Section: Introductionmentioning

confidence: 99%

Biomass-derived carbon dots as fluorescent quantum probes to visualize and modulate inflammation

Kumar,

Chinnathambi,

Bakhori

et al. 2024

Sci Rep

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“…The abundant raw material has led to much research on CQD from natural ingredients derived from plant parts such as fenugreek seeds 6 , watermelon rinds 7 , cucumber and green pepper 8 , Catharanthus roseus (white flowering plant) leaves 9 , milk, pepper, coriander, honey, garlic, curcumin, rice husks 10 . Apart from that, it has been synthesized from green mustard stems, green mustard leaves, Cerbera manghas skin, Cerbera manghas flesh, yellow pumpkin skin, and yellow pumpkin flesh 11 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Optical Properties of Carbon Quantum Dots (CQD) Based on Mustard Green (Brassica juncea L) Leaf with Urea Addition

Yuniarti,

Nurlaela

2023

Valensi

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Carbon quantum dots (CQDs) are a class of fluorescent carbon nanomaterials. Carbon quantum dots (CQDs) were synthesized in this work from Mustard Leaves (Brassica juncea L) with the Addition of Urea via a microwave-assisted reflux method. This research aims to characterize CQDs' optical properties, energy gap, and emission under UV light computationally and experimentally. The studied optical properties obtained the maximum absorption peak observed from the UV-Vis spectrum of CQDs without urea shown at 233 nm. The UV-Vis spectrum of CQDs with the addition of urea (1 g, 1.5 g, and 2 g urea) has maximum absorption peaks at 424 nm, 422 nm, and 418 nm. The addition of urea causes a shift in the peak of the UV-Vis absorption spectrum towards red wavelengths (redshift). CQDs display bright green emissions when exposed to UV irradiation. In this work, the structures of CQDs of various forms (CQD-24, CQD-54, CQD-24-NH2, CQD-54-NH2) are theoretically studied in detail, and the results present both models (CQD-24, CQD-54) shows that the calculation results are in accordance with the experimental results, namely having a maximum UV-Vis absorption at 233 nm and in the range 200-400 nm. The results of calculations based on experiments show the same trend, namely that with the addition of urea, there is a shift in the absorption peak (redshift). The gap energy obtained also decreased with the addition of urea. CQDs solution emits yellow-green light.

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Carbon quantum dots derived from marine Eucheuma denticulatum for the efficient and sensitive detection of tetracycline

Li,

Luo,

et al. 2024

J Nanopart Res

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Development of biomass waste-based carbon quantum dots and their potential application as non-toxic bioimaging agents

Abstract: This paper unequivocally examines the production of carbon quantum dots from biomass waste, such as palm kernel shells and oyster shells, and their application in bioimaging. We also prepared carbon quantum dots from citric acid as a comparison.

Cited by 17 publications

References 73 publications

Biomass-derived carbon dots as fluorescent quantum probes to visualize and modulate inflammation

Biomass-derived carbon dots as fluorescent quantum probes to visualize and modulate inflammation

Synthesis and Characterization of Optical Properties of Carbon Quantum Dots (CQD) Based on Mustard Green (Brassica juncea L) Leaf with Urea Addition

Carbon quantum dots derived from marine Eucheuma denticulatum for the efficient and sensitive detection of tetracycline

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