Development of biomedical hydrogels for rheumatoid arthritis treatment

Baig, Mirza Muhammad Faran Ashraf; Wong, Lee Ki; Zia, Abdul Wasy; Wu, Hongkai

doi:10.1016/j.ajps.2024.100887

Cited by 7 publications

(1 citation statement)

References 116 publications

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“…Consequently, PLGA microspheres tend to display a triphasic release mode consisting of an initial burst, lag phase with slow drug release, and accelerated release due to autocatalytic degradation of PLGA degradation products bearing carboxyl groups . Additionally, hydrogels − as water-swollen polymeric materials have excellent drug-loading capacity and biocompatibility and can be directly injected into inflammatory sites, so they have been widely applied in RA research. However, the burst drug release of the traditional hydrogel is hard to avoid.…”

Section: Introductionmentioning

confidence: 99%

pH-Sensitive Degradable Poly(ortho ester)-Polyesters As Injectable Viscous Fluid for Long-Acting Rheumatoid Arthritis Treatment

Liao,

Zheng,

Qiu

2024

ACS Appl. Polym. Mater.

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This study focuses on the development and evaluation of injectable drug delivery systems for the long-acting treatment of rheumatoid arthritis. Four types of poly(ortho ester)-polyesters (POC2, POC3, POL2, and POL3) were synthesized by the polycondensation reactions between an ortho ester diamine monomer and the active esters of oligocaprolactone diols (A-OCL) or oligolactide diols (A-OLA) with different molecular weights and exhibited discrepant zero-shearing viscosities and hydrophilic–hydrophobic properties. The degradation behaviors were collectively controlled by surface erosion and bulk degradation mechanisms, and the accelerated degradation at pH 5.0 was observed due to acid-responsive hydrolysis of ortho ester and ester groups. Consequently, the release of indomethacin (IND) was well sustained with the kinetics fitting of the Ritger–Peppas model. After being injected subcutaneously once into adjuvant-induced arthritis rats, the formulation IND-POC2 slowly released IND for up to 14 days and showed the best therapeutic effects on effectively alleviating the swelling of joints, bone erosion, and the expression of pro-inflammatory factors. To sum up, this research demonstrated the cheerful prospect of the obtained functional viscous poly(ortho ester)-polyester fluid for sustained drug release in rheumatoid arthritis disease.

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Section: Introductionmentioning

confidence: 99%

pH-Sensitive Degradable Poly(ortho ester)-Polyesters As Injectable Viscous Fluid for Long-Acting Rheumatoid Arthritis Treatment

Liao,

Zheng,

Qiu

2024

ACS Appl. Polym. Mater.

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Anti-inflammatory supramolecular hydrogel loaded chicoric acid based on graphene oxide modified hyaluronic acid and polyethylene glycol for rheumatoid arthritis treatment

Zhou,

Hao,

Yao

et al. 2025

International Journal of Biological Macromolecules

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Modular Synthetic Platform to Tailor Therapeutic-Specific Delivery in Injectable Hydrogels

Wong,

Sim,

Owh

et al. 2024

ACS Appl. Mater. Interfaces

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Injectable thermoresponsive hydrogels (thermogels), valued for their conformability and minimal invasiveness, are increasingly used as in situ forming implants for drug delivery and as regenerative scaffolds. These gels exhibit sol-to-gel phase transitions at body temperature. As localized depots and scaffolds, these gels determine the chemical and mechanical environments and could dramatically influence the release kinetics of drugs or the fate of cells. Current synthetic approaches for thermogels, however, often limit the ability to fully exploit interactions between the thermogel matrix and the encapsulated agent. In this study, we introduce a modular synthetic platform for creating a library of functionalized polyurethane thermogels that enables customization of gelation properties and intermolecular interactions. These thermogels can exhibit a wide range of stiffness, offer complementary ionic interactions, and enhance hydrophobic interactions and hydrogen bonding. By leveraging these tunable interactions between the thermogelling scaffold, functional groups, and encapsulated agents, we achieved sustained and controlled release, from days to over 6 months, for both low and high molecular weight drug analogs. Release profiles varied from monophasic to biphasic and triphasic depending on the compatibility between the thermogel properties and the encapsulated agents. The design rules identified here support the development of drug-specific formulations, facilitating precise, sustained, and modulated release tailored to therapeutic needs. Beyond providing an adaptable strategy for customizable injectable drug depots, this synthetic strategy lays the groundwork for future iterations of multi stimuli-responsive thermogels with enhanced bioactivity, advancing the potential for customizable, biointeractive therapeutic systems.

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Development of biomedical hydrogels for rheumatoid arthritis treatment

Cited by 7 publications

References 116 publications

pH-Sensitive Degradable Poly(ortho ester)-Polyesters As Injectable Viscous Fluid for Long-Acting Rheumatoid Arthritis Treatment

pH-Sensitive Degradable Poly(ortho ester)-Polyesters As Injectable Viscous Fluid for Long-Acting Rheumatoid Arthritis Treatment

Anti-inflammatory supramolecular hydrogel loaded chicoric acid based on graphene oxide modified hyaluronic acid and polyethylene glycol for rheumatoid arthritis treatment

Modular Synthetic Platform to Tailor Therapeutic-Specific Delivery in Injectable Hydrogels

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