Development of bone-like zirconium oxide nanoceramic modified chitosan based porous nanocomposites for biomedical application

Bhowmick, Arundhati; Pramanik, Nilkamal; Jana, Piyali; Mitra, Tapas; Gnanamani, A.; Das, Manas; Kundu, Patit Paban

doi:10.1016/j.ijbiomac.2016.11.052

Cited by 49 publications

(22 citation statements)

References 21 publications

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“…CS-nZrO scaffolds, among the composites, had slightly higher water absorption compared to CS-nHA and CS-nCZ scaffolds, at both time points. This could be due to the presence of hygroscopic metal oxide surface of nZrO that increased the water absorption capacity of CS-nZrO as well as possible interaction of calcium and phosphate in nHA and calcium in nCZ to OH and NH 2 groups in CS that decreased the water absorption capacity of CS-nHA and CS-nCZ scaffolds [22, 37].…”

Section: 0 Results and Discussionmentioning

confidence: 99%

“…The presence of zirconium has been shown to improve the in vitro osteoblasts response [20, 21]. nZrO has been used as filler material into polymeric scaffolds and shown to improve their mechanical and swelling properties without causing any cytotoxic effects to the pre-osteoblasts [22–24]. Few studies have reported the attenuation of cell adhesion and proliferation on ZrO rich scaffolds due to the low affinity of ZrO to the proteins [18, 25].…”

Section: Introductionmentioning

confidence: 99%

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Comparative investigation of porous nano-hydroxyapaptite/chitosan, nano-zirconia/chitosan and novel nano-calcium zirconate/chitosan composite scaffolds for their potential applications in bone regeneration

Gaihre

Jayasuriya

2018

Materials Science and Engineering: C

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Zirconium (Zr) based bioceramic nanoparticles, as the filler material to chitosan (CS), for the development of composite scaffolds are less studied compared to hydroxyapatite nanoparticles. This is predominantly due to the biological similarity of nano-hydroxyapatite (nHA; Ca(PO)(OH)) with bone inorganic component. In this study, we compared the physical and biological properties of CS composite scaffolds hybridized with nHA, nano-zirconia (nZrO; ZrO), and nano-calcium zirconate (nCZ; CaZrO). For the first time in this study, the properties of CS-nCZ composite scaffolds have been reported. The porous composite scaffolds were developed using the freeze-drying technique. The compressive strength and modulus were in the range of 50-55 KPa and 0.75-0.95 MPa for composite scaffolds, significantly higher (p < 0.05), compared to CS alone scaffolds (28 KPa and 0.25 MPa) and were comparable among CS-nHA, CS-nZrO, and CS-nCZ scaffolds. Peak force quantitative nanomechanical mapping (PFQNM) using an atomic force microscope (AFM) showed that the Young's modulus of composite material was higher compared to only CS (p < 0.001), and the values were similar among the composite materials. One of the major issues in the use of Zr based bioceramic materials in bone tissue regeneration applications is their lower osteoblasts response. This study has shown that CS-nCZ supported higher proliferation of pre-osteoblasts compared to CS-nZrO and the spreading was more similar to that observed in CS-nHA scaffolds. Taken together, results show that the physical and biological properties, studied here, of CS composite with Zr based bio-ceramic was comparable with CS-nHA composite scaffolds and hence show the prospective of CS-nCZ for future bone tissue engineering applications.

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Section: 0 Results and Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparative investigation of porous nano-hydroxyapaptite/chitosan, nano-zirconia/chitosan and novel nano-calcium zirconate/chitosan composite scaffolds for their potential applications in bone regeneration

Gaihre

Jayasuriya

2018

Materials Science and Engineering: C

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“…Apart from Zr nanoparticles, zirconia or zirconium oxide (ZrO 2 ) is one of the qualified ceramic biomaterials. Given the excellent chemical stability, biocompatibility, toughness, and mechanical strength, zirconia has been attracted a great deal of interest in regenerative medicine strategies especially, tissue engineering (Bhowmick et al, 2017, Pattnaik et al, 2011). In the context of bone tissue engineering, it has been indicated that osteoblasts cells are capable to proliferate and differentiate on this biocompatible material without showing any detrimental reactions (Josset et al, 1999; Pattnaik et al, 2011).…”

Section: Applications Of Metal Nanomaterials For Bone Tissue Engineeringmentioning

confidence: 99%

“…According to these advantages, zirconium oxide can be incorporated into different engineered composites in order to improve their physical and chemical properties. Bhowmick, Pramanik, Jana, et al (2017) designed an organic–inorganic hybrid composite containing Chitosan, poly (ethylene glycol), nanohydroxypatite (CS‐PEG‐HA), and incorporated zirconium oxide nanoparticles (ZrO 2 NPs). In this research, the addition of different amounts of ZrO 2 NPs (0.1 to 0.3 wt%) was accompanied by some alternations in physical and chemical properties of CS‐PEG‐HA composite.…”

Section: Applications Of Metal Nanomaterials For Bone Tissue Engineeringmentioning

confidence: 99%

Metal‐based nanoparticles for bone tissue engineering

Eivazzadeh‐Keihan

Noruzi

Chenab

et al. 2020

J Tissue Eng Regen Med

151

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Tissue is vital to the organization of multicellular organisms, because it creates the different organs and provides the main scaffold for body shape. The quest for effective methods to allow tissue regeneration and create scaffolds for new tissue growth has intensified in recent years. Tissue engineering has recently used some promising alternatives to existing conventional scaffold materials, many of which have been derived from nanotechnology. One important example of these is metal nanoparticles. The purpose of this review is to cover novel tissue engineering methods, paying special attention to those based on the use of metal‐based nanoparticles. The unique physiochemical properties of metal nanoparticles, such as antibacterial effects, shape memory phenomenon, low cytotoxicity, stimulation of the proliferation process, good mechanical and tensile strength, acceptable biocompatibility, significant osteogenic potential, and ability to regulate cell growth pathways, suggest that they can perform as novel types of scaffolds for bone tissue engineering. The basic principles of various nanoparticle‐based composites and scaffolds are discussed in this review. The merits and demerits of these particles are critically discussed, and their importance in bone tissue engineering is highlighted.

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“…Zirconium has been employed in different research studies on bone tissue engineering [11,12,14]. Zirconium oxide nanoparticles (ZrO2 NPs) were incorporated for the first time in organic-inorganic hybrid composites containing chitosan, poly(ethylene glycol) and nano-hydroxypatite (CS-PEG-HA) to develop bone-like nanocomposites for bone tissue engineering application.…”

Section: Nanoceramics In Bone Tissue Engineeringmentioning

confidence: 99%

Nanoceramics in Bone Tissue Engineering: The Future Lies Ahead

Singh¹

2018

TJSR

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Nanoceramics are composed of ceramics and are classified as inorganic, heat-resistant, nonmetallic solids made of both metallic and nonmetallic compounds. Bone tissue engineering applies bioactive scaffolds, host cells and osteogenic signals for restoring damaged or diseased tissues. Composites of bioactive ceramics closely match the properties of bone. In the present review paper, an attempt has been made to emphasize the suitability of nanoceramics in the field of bone tissue engineering. Toxicity of these synthesized nanomaterials should be checked before their real application. Nanoceramics, in future, will surely prove to be important nanomaterials in the field of tissue engineering.

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Development of bone-like zirconium oxide nanoceramic modified chitosan based porous nanocomposites for biomedical application

Cited by 49 publications

References 21 publications

Comparative investigation of porous nano-hydroxyapaptite/chitosan, nano-zirconia/chitosan and novel nano-calcium zirconate/chitosan composite scaffolds for their potential applications in bone regeneration

Comparative investigation of porous nano-hydroxyapaptite/chitosan, nano-zirconia/chitosan and novel nano-calcium zirconate/chitosan composite scaffolds for their potential applications in bone regeneration

Metal‐based nanoparticles for bone tissue engineering

Nanoceramics in Bone Tissue Engineering: The Future Lies Ahead

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