Development of carboxymethyl cellulose nonwoven sheet as a novel hemostatic agent

Ohta, Seiichi; Nishiyama, Takayuki; Sakoda, Megumu; Machioka, Kyoko; Fuke, Masaya; Ichimura, Shigetoshi; Inagaki, Fuyuki; Shimizu, Atsushi; Hasegawa, Kiyoshi; Kokudo, Norihiro; Kaneko, Makoto; Yatomi, Yutaka; Ito, Taichi

doi:10.1016/j.jbiosc.2014.10.026

Cited by 51 publications

(29 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Either natural or synthetic polymers have been employed for the construction of hemostatic agents. The configurations of these agents are mostly sheet [7], sponge [8–9] and glue [10]. Natural polymers have been widely used as topical hemostatic agents for their excellent properties such as biodegradability and biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Isolation, Characterization and Evaluation of Collagen from Jellyfish Rhopilema esculentum Kishinouye for Use in Hemostatic Applications

et al. 2017

View full text Add to dashboard Cite

Hemostat has been a crucial focus since human body is unable to control massive blood loss, and collagen proves to be an effective hemostat in previous studies. In this study, collagen was isolated from the mesoglea of jellyfish Rhopilema esculentum Kishinouye and its hemostatic property was studied. The yields of acid-soluble collagen (ASC) and pepsin-soluble (PSC) were 0.12% and 0.28% respectively. The SDS-PAGE patterns indicated that the collagen extracted from jellyfish mesoglea was type I collagen. The lyophilized jellyfish collagen sponges were cross-linked with EDC and interconnected networks in the sponges were revealed by scanning electron microscope (SEM). Collagen sponges exhibited higher water absorption rates than medical gauze and EDC/NHS cross-linking method could improve the stability of the collagen sponges. Compared with medical gauze groups, the blood clotting indexes (BCIs) of collagen sponges were significantly decreased (P < 0.05) and the concentration of collagen also had an influence on the hemostatic property (P < 0.05). Collagen sponges had an improved hemostatic ability compared to the gauze control in tail amputation rat models. Hemostatic mechanism studies showed that hemocytes and platelets could adhere and aggregate on the surface of collagen sponge. All properties make jellyfish collagen sponge to be a suitable candidate used as hemostatic material and for wound healing applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Isolation, Characterization and Evaluation of Collagen from Jellyfish Rhopilema esculentum Kishinouye for Use in Hemostatic Applications

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The ovary was directly wrapped with hemostatic gauze in the present study, which provided a physical barrier to protect against displacement of the tumor graft. Cellulose facilitated the formation of clots, in which fibrin and tissue factors promoted cancer angiogenesis [ 5 , 6 ]. Complete absorption and dissolution of cellulose and the dorsal approach decreased adhesion in the peritoneal cavity.…”

Section: Resultsmentioning

confidence: 99%

An Advanced Orthotopic Ovarian Cancer Model in Mice for Therapeutic Trials

Zhang

Luo

Zheng

et al. 2016

BioMed Research International

View full text Add to dashboard Cite

A nude mouse received subcutaneous injection of human ovarian cancer cells HO-8910PM to form a tumor, and then the tumor fragment was surgically transplanted to the ovary of a recipient mouse to establish an orthotopic cancer model. Tumors occurred in 100% of animals. A mouse displayed an ovarian mass, ascites, intraperitoneal spread, and lung metastasis at natural death. The mean survival time was 34.1 ± 17.2 days, with median survival time of 28.5 days. The findings indicated that the present mouse model can reflect the biological behavior of advanced human ovarian cancers. This in vivo model can be used to explore therapeutic means against chemoresistance and metastasis, and an effective treatment would prolong the survival time.

show abstract

“…Although OC had been extensively investigated as a hemostatic agent, it possessed obvious clinical disadvantages originating from the low pH of many carboxyl groups, which significantly limited the sensitive tissue (nervous and cardiac systems) therapy (Ohta et al, 2015). To address this problem, scientists have spent efforts on the improvement of its hemostatic applications.…”

Section: Cellulosementioning

confidence: 99%

Recent Advances on Synthetic and Polysaccharide Adhesives for Biological Hemostatic Applications

Chen

Wang

et al. 2020

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Rapid hemostasis and formation of stable blood clots are very important to prevent massive blood loss from the excessive bleeding for living body, but their own clotting process cannot be completed in time for effective hemostasis without the help of hemostatic materials. In general, traditionally suturing and stapling techniques for wound closure are prone to cause the additional damages to the tissues, activated inflammatory responses, short usage periods and inevitable second operations in clinical applications. Especially for the large wounds that require the urgent closure of fluids or gases, these conventional closure methods are far from enough. To address these problems, various tissue adhesives, sealants and hemostatic materials are placed great expectation. In this review, we focused on the development of two main categories of tissue adhesive materials: synthetic polymeric adhesives and naturally derived polysaccharide adhesives. Research of the high performance of hemostatic adhesives with strong adhesion, better biocompatibility, easy usability and cheap price is highly demanded for both scientists and clinicians, and this review is also intended to provide a comprehensive summarization and inspiration for pursuit of more advanced hemostatic adhesives for biological fields.

show abstract

Development of carboxymethyl cellulose nonwoven sheet as a novel hemostatic agent

Cited by 51 publications

References 27 publications

Isolation, Characterization and Evaluation of Collagen from Jellyfish Rhopilema esculentum Kishinouye for Use in Hemostatic Applications

Isolation, Characterization and Evaluation of Collagen from Jellyfish Rhopilema esculentum Kishinouye for Use in Hemostatic Applications

An Advanced Orthotopic Ovarian Cancer Model in Mice for Therapeutic Trials

Recent Advances on Synthetic and Polysaccharide Adhesives for Biological Hemostatic Applications

Contact Info

Product

Resources

About