Development of cell-enhanced chitosan scaffolds to overcome long gaps after peripheral nerve injury

Wróbel, Sandra; Morano, Michela; Meyer, Cora; Shahar, A.; Ziv, Omer; Haastert‐Talini, Kirsten; Geuna, Stefano; Grothe, Claudia

doi:10.1016/j.jcyt.2014.01.378

Cited by 1 publication

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“…Schwann cells are also involved in the myelination of the regenerating axons [29], which facilitates their pathway toward the distal end [30], thereby improving nerve regeneration [31]; and hence their presence appears to be indispensable for sustainable nerve regeneration over longer segmental defects [32]. Therefore, at the injury site, Schwann cells aids the onset of healthy nerve regeneration, resulting in enhanced axonal regeneration [31], which expedites the repair process [33], and ultimately helps to attain functional recovery comparable to nerve grafting that is better than repair performed using prostheses alone [13,34].…”

Section: Effectiveness Of Cell Therapymentioning

confidence: 99%

A Systematic Review of the Effectiveness of Cell-Based Therapy in Repairing Peripheral Nerve Gap Defects

2020

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Nerve prostheses are widely utilized to reconstruct segmental (gap) defects in peripheral nerves as an alternative to nerve grafting. However, with increasing gap length, the effectiveness of a nerve prosthesis becomes sub-optimal, which subsequently has made repairing larger gaps in peripheral nerves a significant challenge in the field of regenerative medicine. Recently, the structure of nerve prostheses has been significantly revised, which interestingly, has provided a promising avenue for the housing and proliferation of supportive cells. In this systematic review, cell implantation in synthetic nerve prostheses to enhance the regenerative capability of an injured nerve with a focus on identifying the cell type and mode of cell delivery is discussed. Of interest are the studies employing supportive cells to bridge gaps greater than 10 mm without the aid of nerve growth factors. The results have shown that cell therapy in conjunction with nerve prostheses becomes inevitable and has dramatically boosted the ability of these prostheses to maintain sustainable nerve regeneration across larger gaps and helped to attain functional recovery, which is the ultimate goal. The statistical analysis supports the use of differentiated bone-marrow-derived mesenchymal stem cells suspended in oxygen-carrying hydrogels in chitosan prostheses for bridging gaps of up to 40 mm; however, based on the imperfect repair outcomes, nerve grafting should not yet be replaced altogether.

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