Development of cellulosic-based hemostatic dressing with antibacterial activity

Abstract

A cotton-based hemostatic dressing featuring antibacterial properties was developed with the potential of being used in traffic accidents to control hemorrhage. Cotton gauze was oxidized initially in an acidic medium and then coated by PVA nanofibers and/or PVA nanofibers loaded with Ciprofloxacin. Fabricated dressings were characterized by FTIR analysis and SEM images. The FTIR spectrum showed the existence of carboxyl groups on the oxidized cotton gauze's surface. The carboxyl groups content was estimated to be 17.3 ± 0.3 for the oxidized sample with a mixture of nitric acid and phosphoric acid for 24 h (OCF-Mixed acid24). Moreover, the effect of the exposure duration of cotton gauze in the acidic medium on the blood coagulation activity was assessed. It was observed that the OCF-Mixed acid24 sample exhibited an agreeable hemostatic activity (BCIs = 10). The antibacterial activity against E. coli and S. aureus bacteria was also captured for the coated cotton gauze by the PVA nanofibers loaded with Ciprofloxacin.

Preparation and Activity of Hemostatic and Antibacterial Dressings with Greige Cotton/Zeolite Formularies Having Silver and Ascorbic Acid Finishes

“…A nanocomposite of carboxymethylated cellulose nanofibers treated with silver nanoparticles and gelatin was formed into a crosslinked hydrogel and reported to have good antibacterial and satisfactory hemostatic activity [14]. A cotton gauze dressing coated with polyvinyl alcohol nanofibers and loaded with ciprofloxacin demonstrated antibacterial activity against E. coli and S. aureus, with an improved blood coagulation index resulting from a longer acid-based oxidation of the cotton [15]. To improve both antibacterial and hemostatic activity while exerting an effect on the vascularization component of wound healing, a glucagon-like peptide analog was combined with zinc oxide on electrospun poly(L-lactide-co-glycolide) gelatin nanofiber.…”

“…Results of the liquid absorptive capacity testing of the treated TGz strips according to the EDANA/INDA test method NWSP 010.1.R0(15).…”

Poly(N-vinyl caprolactam-co-maleic anhydride)-grafted cotton gauze with antimicrobial properties for their potential use as wound dressings

“…Cotton gauzes are commonly used in injury therapy because they absorb a large amount of exudate, promote healing, and reduce the formation of scars (Bruin et al 1990). Besides, they are nontoxic, non-irritating, low-cost, and provide physical protection (Goodarz et al 2022).…”