Development of CeO2 nanodot encrusted TiO2 nanoparticles with reduced photocatalytic activity and increased biocompatibility towards a human keratinocyte cell line

Morlando, Alexander; Borras, Marcela Chaki; Rehman, Yaser; Bakand, Shahnaz; Barker, Philip; Sluyter, Ronald; Konstantinov, Konstantin

doi:10.1039/d0tb00629g

Cited by 24 publications

(23 citation statements)

References 66 publications

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“…These are pseudo first-order rate reactions described by the Langmuir−Hinshelwood model. Rate constants (k) min −1 were determined from the linear plot of ln(C 0 /C) vs irradiation time using the expression: 10,35 i k j j j y…”

Section: Resultsmentioning

confidence: 99%

“…Structural defects and oxygen vacancies play a major role for scavenging of e-/h+ and ROS. 10 The presence of lattice defects and oxygen vacancies decreased the band gap between the conduction band and valence band. The chemistry of defects in the four coordinated position or six coordinated position affects the equilibrium octahedral structure of La 2 O 3 .…”

Section: Resultsmentioning

confidence: 99%

“…The nanoparticles were suspended in CH 3 CH 2 OH by sonication (Branson 3800, Ultrasonic Corp.) before analysis. The optical band gap (E g ) of the samples were determined from the Tauc relation: 10,23…”

Section: Methodsmentioning

confidence: 99%

“…It has shown promising ROS scavenging properties due to its redox cycling between the Ce 3+ /Ce 4+ oxidation states. The redox efficiency of cerium depends upon the ratio of Ce 4+ and Ce 3+ ions and is controlled through oxygen deficiencies and defects in the structure. ,− The introduction of oxygen vacancies and other defects into nanostructures are vital to attain the desired oxidation states for achieving optimum catalytic antioxidant performance.…”

Section: Introductionmentioning

confidence: 99%

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Defect-Rich La₂O₃ Nanoparticles with Antioxidant Activity for Human Keratinocytes

Rehman

Morlando

Borras

et al. 2021

ACS Appl. Nano Mater.

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A deficiency in the human antioxidant system to scavenge free radicals results in mounting oxidative stress, causing various pathological conditions including immune system constraints. To support an underperforming antioxidant system and regulate homeostatic function, efficient and biocompatible reactive oxygen species (ROS) scavengers may be employed. At present, metal oxide-based antioxidants nanoparticles are of fundamental interest because of their smart surface property tailoring. A spray precipitation method was employed in this work to develop a strained and defect rich lanthanum oxide (La 2 O 3 ) nanostructure. A contraction in d-spacing and distortion in planes and vacancies were observed in the nanostructure, causing microstrain as verified by the William-Hall uniform deformation model (UDM). Photocatalytic activity was evaluated against commercial La 2 O 3 and Evonik Aeroxide TiO 2 P25 via dye degradation experiments. A 30% degradation reduction confirmed the ability of the nanostructure to scavenge free radicals generated by P25 upon ultraviolet (UV) irradiation. Compared to the commercial La 2 O 3 , the nanostructured La 2 O 3 showed an increase in UV absorption (200−400) nm due to a decrease in the optical band gap. A positive surface charge of the nanoparticles was observed from zeta potential measurements, suggesting sufficient colloidal stability. In vitro toxicity studies toward the nonmalignant human keratinocyte cell line (HaCaT) over a 24 h treatment period with the La 2 O 3 nanoparticles exhibited no toxicity in comparison with the control and ZnO nanoparticles. The antioxidant properties of the nanoparticles were investigated by a dichlorofluorescein (DCF)-based assay which revealed a decrease in intracellular ROS in comparison with Nacetylcysteine (NAC) and H 2 O 2 . In addition, confocal microscopy imaging showed the internalization of the nanoparticles and subsequent DCF intensity change between the treated and untreated cells, as supported by flow cytometry analysis. Our findings suggest that defect-rich La 2 O 3 nanoparticles could be used effectively as active inorganic UV filter and fluorescent contrast agent owing to their biocompatible antioxidant properties.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Defect-Rich La₂O₃ Nanoparticles with Antioxidant Activity for Human Keratinocytes

Rehman

Morlando

Borras

et al. 2021

ACS Appl. Nano Mater.

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“…The common precursor is cerium nitrate hexahydrate and the reaction environment is alkaline (seen in Table 1). [44][45][46][47][48] Other precursors and capping agents are still in research and development.…”

Section: Precipitation Methodsmentioning

confidence: 99%

The Advances of Ceria Nanoparticles for Biomedical Applications in Orthopaedics

Li¹,

Xia²,

S³

et al. 2020

IJN

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The ongoing biomedical nanotechnology has intrigued increasingly intense interests in cerium oxide nanoparticles, ceria nanoparticles or nano-ceria (CeO 2-NPs). Their remarkable vacancy-oxygen defect (VO) facilitates the redox process and catalytic activity. The verification has illustrated that CeO 2-NPs, a nanozyme based on inorganic nanoparticles, can achieve the anti-inflammatory effect, cancer resistance, and angiogenesis. Also, they can well complement other materials in tissue engineering (TE). Pertinent to the properties of CeO 2-NPs and the pragmatic biosynthesis methods, this review will emphasize the recent application of CeO 2-NPs to orthopedic biomedicine, in particular, the bone tissue engineering (BTE). The presentation, assessment, and outlook of the orthopedic potential and shortcomings of CeO 2-NPs in this review expect to provide reference values for the future research and development of therapeutic agents based on CeO 2-NPs.

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Modification of ZnO and TiO2 UV filters

Kera,

Pillai,

Ray

2024

SpringerBriefs in Materials

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Development of CeO₂ nanodot encrusted TiO₂ nanoparticles with reduced photocatalytic activity and increased biocompatibility towards a human keratinocyte cell line

Abstract: Low photocatalytic CeO2/TiO2 nanocomposite particles with high UV attenuation and reduced ROS generation for application in sunscreen products.

Cited by 24 publications

References 66 publications

Defect-Rich La₂O₃ Nanoparticles with Antioxidant Activity for Human Keratinocytes

Defect-Rich La₂O₃ Nanoparticles with Antioxidant Activity for Human Keratinocytes

<p>The Advances of Ceria Nanoparticles for Biomedical Applications in Orthopaedics</p>

Modification of ZnO and TiO2 UV filters

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Development of CeO2 nanodot encrusted TiO2 nanoparticles with reduced photocatalytic activity and increased biocompatibility towards a human keratinocyte cell line

Abstract: Low photocatalytic CeO2/TiO2 nanocomposite particles with high UV attenuation and reduced ROS generation for application in sunscreen products.

Cited by 24 publications

References 66 publications

Defect-Rich La2O3 Nanoparticles with Antioxidant Activity for Human Keratinocytes

Defect-Rich La2O3 Nanoparticles with Antioxidant Activity for Human Keratinocytes

<p>The Advances of Ceria Nanoparticles for Biomedical Applications in Orthopaedics</p>

Modification of ZnO and TiO2 UV filters

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Product

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About

Development of CeO₂ nanodot encrusted TiO₂ nanoparticles with reduced photocatalytic activity and increased biocompatibility towards a human keratinocyte cell line

Defect-Rich La₂O₃ Nanoparticles with Antioxidant Activity for Human Keratinocytes

Defect-Rich La₂O₃ Nanoparticles with Antioxidant Activity for Human Keratinocytes