Development of Charcot Neuroarthropathy in Diabetic Patients who Received Kidney or Kidney-Pancreas Transplants

Anthony, Michael Leonard; Cravey, Kimberly S.; Atway, Said

doi:10.1053/j.jfas.2018.09.022

Cited by 12 publications

(7 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Charcot foot has an incidence rate of less than 1% in the general diabetic population [ 10 ]. The incidence rate of peripheral neuropathy in the same population is 9–32% [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…Charcot foot has an incidence rate of less than 1% in the general diabetic population [ 10 ]. The incidence rate of peripheral neuropathy in the same population is 9–32% [ 10 ]. Patients with severe peripheral polyneuropathy have a higher risk of developing Charcot foot, with an estimated prevalence of 13% [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, this condition may be underestimated because it is difficult to diagnose. Several retrospective studies have shown a link between solid organ transplantation and the development of Charcot arthropathy, with an increase in the incidence of Charcot neuroarthropathy in patients who have benefited from kidney–pancreas transplant or kidney-only transplant [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…A study that assessed the rate of patients developing Charcot arthropathy after transplantation (kidney–pancreas and kidney) with post-transplantation follow-up of more than 2 years found that 14.8% of these patients presented with Charcot foot and all these patients had peripheral neuropathy. There was a statistically significant difference between kidney–pancreas transplant patients (18.4%) and single-kidney transplant patients (11%) [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

A Red, Swollen, and Warm Foot in a Kidney–Pancreas-Transplanted Type 1 Diabetic Patient: Is It Always Charcot Foot or Bone and Joint Infection? A Case Report

Memaj,

Correia,

Davat

et al. 2023

Am J Case Rep

View full text Add to dashboard Cite

Patient: Male, 47-year-old Final Diagnosis: Acute Charcot foot Symptoms: Red foot • right foot pain Clinical Procedure: — Specialty: Endocrinology and Metabolic Objective: Unusual clinical course Background: Acute Charcot foot can be difficult to diagnose, especially because of other alternate diagnoses that can mimic this condition, particularly stress fracture and acute bone and joint infections, which are 2 conditions that require immediate management. Here, we present the case of a patient who received kidney-pancreas-transplantation for type 1 diabetes mellitus, who consulted for right foot pain after walking. Case Report: Our patient was a 47-year-old man who had benefited from a kidney-pancreas transplantation in 2014 for type 1 diabetes and terminal kidney failure and was recently followed for a right foot plantar ulcer that was fully healed. He later presented for right foot pain after walking. Clinical examination showed a red, swollen, and warm foot. Blood test results were unremarkable. Imaging (X-ray/MRI) revealed features compatible with acute Charcot foot. The management consisted of prompt right-foot offloading followed by physiotherapy and adapted orthopedic insoles. Conclusions: This case shows the successful treatment of an active phase of Charcot foot, which avoided the classic transition to chronic Charcot foot with severe osteoarticular destruction. Arguments were developed to rule out other possible diagnoses. The underlying mechanisms of Charcot foot in diabetic patients are related to the neurological and micro-vascular complications induced by poor glycemic control, but the mechanisms are unclear. This case report may help clinicians to better understand and consider another less known and less frequent diagnosis when faced with these clinical features.

show abstract

“…Charcot foot has an incidence rate of less than 1% in the general diabetic population [ 10 ]. The incidence rate of peripheral neuropathy in the same population is 9–32% [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A Red, Swollen, and Warm Foot in a Kidney–Pancreas-Transplanted Type 1 Diabetic Patient: Is It Always Charcot Foot or Bone and Joint Infection? A Case Report

Memaj,

Correia,

Davat

et al. 2023

Am J Case Rep

View full text Add to dashboard Cite

show abstract

“…A higher incidence and poorer outcome of this complication is observed in patients with diabetes and concurrent renal disease [25]. Impaired renal function, haemodialysis, peritoneal dialysis, and kidney or simultaneous kidney/pancreas transplantation correlate with the incidence and progression of Charcot neuroarthropathy [25][26][27].…”

Section: Prevalence Symptoms and Risk Factorsmentioning

confidence: 99%

The role of genetic factors and monocyte-to-osteoclast differentiation in the pathogenesis of Charcot neuroarthropathy

Kłoska

Korzon-Burakowska

Malinowska

et al. 2020

Diabetes Research and Clinical Practice

View full text Add to dashboard Cite

Charcot neuroarthropathy is a chronic, progressive condition of the skeletal system that affects some patients with diabetic neuropathy. It results in progressive destruction of bones of the foot and disorganisation of pedal joints and ligaments. Effective prevention and treatment for Charcot neuroarthropathy remain a challenge. Currently, there are no reliable repeatable markers to identify patients with diabetes who are at higher risk of developing Charcot neuroarthropathy. The pathogenesis underlying the development of Charcot neuroarthropathy also remains unclear. In this review, we provide an overview of the history, prevalence, symptoms, risk factors, diagnostics and treatment of Charcot neuroarthropathy. We also discuss the potential for OPG and RANKL gene variants to act as predictive markers for the development of Charcot neuroarthropathy. Finally, we summarise the latest research on the role of monocyte-to-osteoclast differentiation in the development of acute Charcot neuroarthropathy.

show abstract

Charcot Foot Syndrome: Aetiology and Diagnosis

Jeffcoate,

Game

2023

Functional Limb Salvage

View full text Add to dashboard Cite

Development of Charcot Neuroarthropathy in Diabetic Patients who Received Kidney or Kidney-Pancreas Transplants

Cited by 12 publications

References 24 publications

A Red, Swollen, and Warm Foot in a Kidney–Pancreas-Transplanted Type 1 Diabetic Patient: Is It Always Charcot Foot or Bone and Joint Infection? A Case Report

A Red, Swollen, and Warm Foot in a Kidney–Pancreas-Transplanted Type 1 Diabetic Patient: Is It Always Charcot Foot or Bone and Joint Infection? A Case Report

The role of genetic factors and monocyte-to-osteoclast differentiation in the pathogenesis of Charcot neuroarthropathy

Charcot Foot Syndrome: Aetiology and Diagnosis

Contact Info

Product

Resources

About