Development of chitosan nanoparticles as drug delivery system for a prototype capsid inhibitor

Xue, Meiyan; Hu, Steve; Lü, Yifei; Zhang, Yu; Jiang, Xinru; An, Sai; Guo, Yubo; Zhou, Xue; Hou, Huimin; Jiang, Chen

doi:10.1016/j.ijpharm.2015.08.056

Cited by 58 publications

(25 citation statements)

References 35 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bay 41-4109, an active inhibitor of hepatitis B virus was formulated as chitosan NPs to improve drug solubility and oral bioavailability. The cytotoxicity of Bay 41-4109-chitosan NP was found to be negligible and drug uptake was higher from the NPs, which was attributed to the positive charge from the chitosan [44]. Table 1 provides detailed insight into the extensive range of applications of chitosan NP for oral drug delivery.…”

Section: Chitosan In Oral Drug Deliverymentioning

confidence: 99%

“…A PK study in rats demonstrated a 3.3-fold increase in C max , increased AUC and 4-fold increase in absolute bioavailability of chitosan NPs compared to the Bay 41-4109 suspension. The enhanced intestinal absorption of Bay 41-4109 can be attributed to either increased interaction between the positive charge of chitosan with the negative charge of cell membranes or the mucoadhesive character of chitosan NPs, enabling them to release drug over time in the small intestine [44]. Enoxaparin has little to no oral bioavailability.…”

Section: Pharmacokinetics (Pk) Of Chitosan Based Formulationsmentioning

confidence: 99%

See 1 more Smart Citation

An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery

et al. 2017

View full text Add to dashboard Cite

The focus of this review is to provide an overview of the chitosan based nanoparticles for various non-parenteral applications and also to put a spotlight on current research including sustained release and mucoadhesive chitosan dosage forms. Chitosan is a biodegradable, biocompatible polymer regarded as safe for human dietary use and approved for wound dressing applications. Chitosan has been used as a carrier in polymeric nanoparticles for drug delivery through various routes of administration. Chitosan has chemical functional groups that can be modified to achieve specific goals, making it a polymer with a tremendous range of potential applications. Nanoparticles (NP) prepared with chitosan and chitosan derivatives typically possess a positive surface charge and mucoadhesive properties such that can adhere to mucus membranes and release the drug payload in a sustained release manner. Chitosan-based NP have various applications in non-parenteral drug delivery for the treatment of cancer, gastrointestinal diseases, pulmonary diseases, drug delivery to the brain and ocular infections which will be exemplified in this review. Chitosan shows low toxicity both in vitro and some in vivo models. This review explores recent research on chitosan based NP for non-parenteral drug delivery, chitosan properties, modification, toxicity, pharmacokinetics and preclinical studies.

show abstract

Section: Chitosan In Oral Drug Deliverymentioning

confidence: 99%

Section: Pharmacokinetics (Pk) Of Chitosan Based Formulationsmentioning

confidence: 99%

An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The initial burst release possibly occurred due to release of antigen from the surface of nanoparticle. The second constant release could be due to the release of antigen from the core of NPs as a consequence of CS hydration and swelling [38,39]. The data of release showed that MCH NPs released antigen faster than CS NPs.…”

Section: Release Profile Studymentioning

confidence: 99%

Development and physicochemical, toxicity and immunogenicity assessments of recombinant hepatitis B surface antigen (rHBsAg) entrapped in chitosan and mannosylated chitosan nanoparticles: as a novel vaccine delivery system and adjuvant

Mehrabi

Dounighi

Sorkhabadi

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

View full text Add to dashboard Cite

In this study chitosan nanoparticles (CS NPs) and mannosylated chitosan nanoparticles (MCH NPs) loaded with recombinant hepatitis B surface antigen (rHBsAg) was synthesized as a vaccine delivery system and assessed toxically and immunologically. The physicochemical properties of the nanoparticles (NPs) were determined by methods including scanning electron microscope (SEM) and dynamic light scattering (DLS). The morphology of the NPs was semi spherical and the average diameter of the loaded CS and MCH NPs was found to be 189 and 239 nm, respectively. The release studies showed that after the initial burst, both of the loaded NPs provided a continuous and slow release of the antigens. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay showed concentration and time dependent toxicity profile for both formulations, but rHBsAg loaded CS nanoparticle showed higher toxicity due to smaller particle size and larger zeta potential. Abnormal toxicity test (ATT) results showed no signs of toxicity in mice and guinea-pigs treated with loaded MCHNPs. Stability test for six months showed acceptable changes in size, surface charge, and antigenicity for loaded MCH nanoparticles. Finally, in vivo immunogenicity study revealed greater adjuvant capability of MCH nanoparticles than others formulations. Our results showed MCH NPs can be used as a controlled and targeted vaccine delivery system.

show abstract

“…For example, they are not antigenic, can be metabolized, have high stability and allow for high loading for water soluble active substances (Muller et al, 1996). Chitosan, a natural biodegradable polymer, is often used in the preparation of particular dosage forms (Bodmeier, Oh, Pramar, 1989;Aral, Akbuğa, 1998;Shu, Zhu, 2002;Norkar, Sher, Pawar, 2010;Sharma et al, 2012;Al-Qadi et al, 2012, Zhang, Wang, Pan, 2014Vivek et al, 2014;Koppolu et al, 2014;Xue et al, 2015;Chen et al, 2016;Ganguly, Kulkarni, Aminabhavi, 2016). A cationic linear bioamino polysaccharide, chitosan, is obtained by means of alkali distillation of chitin (Illum, 1998).…”

Section: Introductionmentioning

confidence: 99%

Investigation of the parameters affecting the release of flurbiprofen from chitosan microspheres

Tilkan

Özdemir

2018

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

Flurbiprofen (FLB), a NSAID, widely used for preventing pain generally for arthritis or dental problems. In this study, FLB loaded chitosan microspheres were prepared by ionotropic gelation method. In this method, microspheres were formed by dropping chitosan solutions containing FLB into sodium alginate solutions including sodium tripolyphosphate (TPP). A variety of formulation parameters like drug:polymer ratio, drug concentration, polymer's molecular weight, polymer concentration, pH and the concentration of TPP solutions, drying method and stirring time were analyzed. The dissolution studies were performed in a shaking water bath in pH 7.4 phosphate buffer saline (PBS) at 37 °C. Laser diffractometer was used for particle size analysis, and scanning electron microscope (SEM) was used for morphological properties. Drug loading and loading efficiency were calculated by using UV spectrophotometer. The particles obtained were spherical with 0.7-1.3 mm size range, and the loading efficiency was approximately 21-79%. The dissolution studies conducted revealed that drug:polimer ratio and the polymer type and concentration affected the drug release from microspheres. It was observed that increasing the polymer concentration, polymer's molecular weight and TPP concentration decreased the FLB release from microspheres, which was according to Higuchi kinetics.

show abstract

Development of chitosan nanoparticles as drug delivery system for a prototype capsid inhibitor

Cited by 58 publications

References 35 publications

An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery

An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery

Development and physicochemical, toxicity and immunogenicity assessments of recombinant hepatitis B surface antigen (rHBsAg) entrapped in chitosan and mannosylated chitosan nanoparticles: as a novel vaccine delivery system and adjuvant

Investigation of the parameters affecting the release of flurbiprofen from chitosan microspheres

Contact Info

Product

Resources

About