Development of chitosan/β-glycerophosphate/glycerol hydrogel as a thermosensitive coupling agent

Huang, Ching-Lien; Chen, Yu Bin; Lo, Yu Lung; Lin, Yi Hsiang

doi:10.1016/j.carbpol.2016.04.028

Cited by 35 publications

(14 citation statements)

References 21 publications

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“…The gelation time became shorter as the volume ratio of CS to β‐GP decreased, which was consistent with previous studies . The mechanism for the phase transformation character‐based temperature included molecular chain movements, electrostatic interactions, hydrogen bonding, and hydrophobic interactions . More β‐GP induced diminished electrostatic interactions and increased hydrophobic interactions between CS chains, resulting in shorter gelation time .…”

Section: Discussionsupporting

confidence: 89%

“…45,46 The mechanism for the phase transformation character-based temperature included molecular chain movements, electrostatic interactions, hydrogen bonding, and hydrophobic interactions. [45][46][47] More β-GP induced diminished electrostatic interactions and increased hydrophobic interactions between CS chains, resulting in shorter gelation time. 45 Thus, we could obtain an ideal gelation time by adjusting the concentration and volume of CS and β-GP.…”

Section: Discussionmentioning

confidence: 99%

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A thermosensitive chitosan‐based hydrogel for sealing and lubricating purposes in dental implant system

Cao

Cai

Chen

et al. 2019

Clin Implant Dent Rel Res

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Background Mechanical and biological complications associated with implant systems happen frequently in the clinic. Purpose To develop a chitosan (CS)‐based thermosensitive hydrogel for sealing and lubricating purposes in dental implant system. Materials and Methods In this study, a thermosensitive hydrogel made up of CS, β‐glycerophosphate pentahydrate (β‐GP), and povidone‐iodine (PVP‐I), called CS/β‐GP/PVP‐I thermosensitive hydrogel, was fabricated. Three experimental groups with different volume ratios of CS to β‐GP were prepared, namely 16/4, 13/7, and 10/10 groups. The surface topography of the different groups and their physicochemical characteristics were examined by SEM, FTIR, and X‐ray diffraction analysis. The cytotoxicity of the hydrogel was examined by CCK‐8 test. In vitro antibacterial efficiency was analyzed by the spread plate method. Sealing ability was detected by incubating two‐piece implants in Escherichia coli suspension. Lubricating ability of the hydrogel was evaluated by the removal torque test with a calibrated digital torque meter. Results The CS/β‐GP/PVP‐I thermosensitive hydrogel was fabricated and showed a highly porous structure under SEM. An in vitro cytotoxicity test demonstrated that 13/7 group displayed no cytotoxicity. Furthermore, all three groups showed obviously antibacterial effects. In the sealing ability test, 16/4 group showed the best sealing ability. The removal torque of 16/4 group and 13/7 group was significantly greater than control group. Conclusions Based on our findings, it could be concluded that the thermosensitive and antibacterial CS/β‐GP/PVP‐I hydrogel with sealing and lubricating ability was successfully prepared. The hydrogel had better sealing and lubricating effects when the volume ratio of CS to β‐GP was 16/4.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

A thermosensitive chitosan‐based hydrogel for sealing and lubricating purposes in dental implant system

Cao

Cai

Chen

et al. 2019

Clin Implant Dent Rel Res

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“…The hydrogel preparation was fabricated by the previously reported methods. 41 - 43 In this examination, the 3 components of the CD@β-GP hydrogels as below. The C solution was synthesized by the dissolving of C (150 mg) in 7 mL acetic acid solution under RT.…”

Section: Methodsmentioning

confidence: 99%

Synergistic Fabrication of Dose–Response Chitosan/Dextran/β-Glycerophosphate Injectable Hydrogel as Cell Delivery Carrier for Cardiac Healing After Acute Myocardial Infarction

Chen

Liu

Hua³

et al. 2020

Dose-Response

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The human mesenchymal stem cells (hMSCs) therapy offering an encouraging the new methods to establish the conveying on the chitosan (C)/dextran (D)/β-glycerophosphate (β-GP) loaded with hMSCs to enhance the acute myocardial infarctions. The synthesized hMSCs-CD@β-GP system displayed the ratio of determination modules, size of the pore, absorbency, and the swellings ratio in the assortment of the 65 ka, 149 ± 39.8 µm, 92.2%, 42 ± 1.38, and 29 ± 1.9, respectively. The fabricated hMSCs-CD@β-GP was highly stable and physicochemical investigated and confirmed the suitability of the materials for cardiac regeneration applications. The in vitro examinations of the injectable hydrogels with hMSCs-CD@β-GP have recognized that the improved survival rate of the cells, increased the pro-inflammatory expressions factors, pro-angiogenic factors analysis confirmed the promising results of the ejection of fractions, fibrosis area, vessel density with decreased infractions size, with suggesting that the remarkable improvement of the heart regenerative function after myocardial infarctions. The new synergistic approach of the injectable hydrogels with hMSCs could able appropriate for the effective treatment of cardiac therapies after acute myocardial infarctions.

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“…Zawadzki et al [27] conducted TGA of CS from room temperature to 600 °C under a nitrogen atmosphere, and suggested that the TGA behaviour of solid CS can be divided into three stages: (1) the removal of water below 100 °C, in which the water was physically adsorbed and/or weakly The protonation could have also enabled CS to possess pH-dependent electrostatic interactions with the phosphate groups on the PGFs in a manner similar to amino silane [50]. Huang et al [51] added glycerol-phosphate to the CS-acetic acid solution and found that the interaction between the NH 3 + and P-OH groups was caused by electrostatic attraction. Chenite et al [52] summarised that the combination of CS and polyol-phosphate salts could have formed hydrogen bonding, electrostatic interactions, and hydrophobic interactions in acetic acid solution.…”

Section: Tgamentioning

confidence: 99%

Chitosan as a Coupling Agent for Phosphate Glass Fibre/Polycaprolactone Composites

Tan

Rudd

Parsons

et al. 2018

Fibers

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This study shows that chitosan (CS) could be highly useful as a coupling agent in phosphate glass fibre/polycaprolactone (PGF/PCL) composites, as it improved the interfacial shear strength by up to 78%. PGFs of the composition 45P2O5–5B2O3–5Na2O–24CaO–10MgO–11Fe2O3 were dip-coated with CS (with a degree of deacetylation >80%) dissolved in acetic acid solution (2% v/v). Different CS concentrations (3–9 g L−1) and coating processes were investigated. Tensile and fragmentation tests were conducted to obtain the mechanical properties of the single fibres and interfacial properties of the PGF/PCL composites, respectively. It was observed that post-cleaning, the treated fibres had their tensile strength reduced by around 20%; however, the CS-coated fibres experienced strength increases of up to 1.1–11.5%. TGA and SEM analyses were used to confirm the presence of CS on the fibre surface. FTIR, Raman, and X-ray photoelectron spectroscopy (XPS) analyses further confirmed the presence of CS and indicated the protonation of CS amine groups. Moreover, the nitrogen spectrum of XPS demonstrated a minimum threshold of CS coating required to provide an improved interface.

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Development of chitosan/β-glycerophosphate/glycerol hydrogel as a thermosensitive coupling agent

Cited by 35 publications

References 21 publications

A thermosensitive chitosan‐based hydrogel for sealing and lubricating purposes in dental implant system

A thermosensitive chitosan‐based hydrogel for sealing and lubricating purposes in dental implant system

Synergistic Fabrication of Dose–Response Chitosan/Dextran/β-Glycerophosphate Injectable Hydrogel as Cell Delivery Carrier for Cardiac Healing After Acute Myocardial Infarction

Chitosan as a Coupling Agent for Phosphate Glass Fibre/Polycaprolactone Composites

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