Development of chronic renal deficiency in spontaneously hypertensive rats

Barabanova, V. V.; Titova, V. A.; Miroshnichenko, E. L.; Timoshenko, T. E.

doi:10.1007/bf00791183

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“…Given that essential hypertension represents 95% of all cases in human population, the SHR strain seems to be an accurate model for studies of the alterations in kidneys as a result of this type of hypertension. A review of the pertinent literature shows that hypertensive glomerulosclerosis and tubular atrophy can be observed in SHR [15]. These alterations were also noted in the present study.…”

Section: Discussionsupporting

confidence: 86%

Light Microscopic Study of Renal Morphological Alterations in Spontaneously Hypertensive Rats

Stanchev

Iliev

Malinova

et al. 2017

Journal of Biomedical and Clinical Research

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SummaryThe impact of hypertension on the kidney is associated with a number of morphological changes, which gradually lead to development of end-stage kidney disease. The aim of the present study was to trace the postnatal histological changes in the morphology of nephrons and renal interstitium in spontaneously hypertensive rats. In this study, we described and compare alterations in renal histology as a consequence of hypertension in two age groups of spontaneously hypertensive rats, aged 2 and 6 months (n=3; per age group). The description of the alterations in renal morphology was made by light microscopic analysis using routine haematoxylin and eosin staining, periodic acid Schiff (PAS) reaction and Mallory's trichrome staining. We did not observe signi cant changes in renal histology in 2-monthold rats: renal corpuscles were relatively well preserved, proximal and distal tubules were clearly demarcated, and no pathological changes in the larger intrarenal blood vessels were found. There was evidence of glomerular and tubular basement membranes thickening and focal interstitial brosis. In 6-month-old rats, we noted pronounced glomerulosclerosis, periglomerular and periarteriolar brosis and expansion of interstitial brosis. The vascular alterations depended on the size of the blood vessels and included hyaline arteriosclerosis, brinoid necrosis and myointimal thickening of interlobular arteries. Untreated hypertensive nephrosclerosis is associated with progressive renal alterations, which cause impaired renal function -a lifelong limiting factor.

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Section: Discussionsupporting

confidence: 86%