Development of clinical simultaneous SPECT/MRI

Hutton, Brian F.; Occhipinti, Michele; Kuehne, André; Máthé, Domokos; Kovács, Noémi; Waiczies, Helmar; Erlandsson, Kjell; Salvado, Debora; Carminati, Marco; Montagnani, G. L.; Short, Susan; Ottobrini, Luisa; Mullekom, P. Van; Piemonte, C.; Bükki, Tamás; Nyitrai, Z.; Papp, Z.; Nagy, Kálmán; Niendorf, Thoralf; Francesco, I. De; Fiorini, C.

doi:10.1259/bjr.20160690

Cited by 65 publications

(37 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Son zamanlarda popüler olmaya başlayan mikroSPECT/ mikroMRG sistemlerinde MRG'nin mükemmel yumuşak doku kontrastı ile SPECT'in yüksek rezolüsyonunun bir araya getirilmesi ile daha uzun süreli gözlem imkanı ve onkolojik, immünolojik ve ilaç geliştirme çalışmalarında yeni birtakım yöntemler kullanılmasına imkan bulunmuştur. (6,39). Yüksek rezolüsyon avantajından faydalanabilmek amacıyla PET dedektörü eklenebilen, silikon PMT'lerin kullanıldığı SiPM-MRG/PET (hyperion-IID-a digital-SiPM-based MRG-compatible PET insert) sitemi de hem anatomik hem fonksiyonel bilginin daha detaylı elde edilmesi amacıyla geliştirilen bir modalitedir (40).…”

Section: Hibridsistemlerunclassified

Imaging Modalities Used in Preclinical Studies

Karaçavuş¹

2019

nts

View full text Add to dashboard Cite

Öz HangiModalite?Deney hayvanlarının noninvaziv görüntülenmesinde hedeflenen amaçlar doğrultusunda farklı modaliteler kullanılmaktadır. En uygun yöntemin seçilmesinde ilgilenilen parametre yani boyut, fonksiyon, istenilen uzaysal ve temporal rezolüsyon ve sensitivite, dinamik veriye ihtiyaç, tüm vücut/bölgesel veri gerekliliği, çekim süresi, penetrasyon derinliği, kantitatif veriye ihtiyaç, çoklu/tekrarlayan çalışmaya ihtiyaç, birden Imaging modalities have long been indispensable tool in clinical and preclinical practice or drug development. Increasingly, in vivo imaging of small laboratory animals has gained importance as a critical component of preclinical biomedical research as well. The most used modalities for small-animal in vivo imaging applications are based on nuclear medicine techniques (especially, positron emission tomography [PET] and single photon emission computed tomography [SPECT]), computed tomography (CT), and magnetic resonance imaging (MRI). Each modality has intrinsic strengths and limitations, and the choice of the imaging modality depends on the parameter of interest.Recently, aiming to overcome the limitations of each imaging modality, multimodality devices designed to provide complementary information upon the pathophysiological process under study have emerged popularity. The combination of high-resolution modalities, like microCT or microMRI, with highly sensitive techniques providing functional information, such as microPET or microSPECT, will continue to broaden the horizons of research in such areas as infection, oncology, cardiology, and neurology, contributing not only to the understanding of the underlying mechanisms of disease but also providing efficient and unique tools for evaluating new chemical entities and development of candidate drugs. Ya zış maAd re si/Ad dressforCor res pon den ce

show abstract

Section: Hibridsistemlerunclassified

Imaging Modalities Used in Preclinical Studies

Karaçavuş¹

2019

nts

View full text Add to dashboard Cite

show abstract

“…This stationary system has the added advantage of facilitating dynamic acquisition, avoiding the problems of rotation inherent in the conventional SPECT systems. Demonstrating feasibility with a demountable head-only insert [55] may stimulate interest in developing whole-body SPECT/MRI, following a similar development pathway to PET/MRI. The challenges in achieving compatibility with MRI are similar to those encountered in PET/MRI, with the added possibility of introducing eddy currents in the collimator.…”

Section: Spectmentioning

confidence: 99%

“…Alternatively, a postreconstruction partial volume correction (PVC) procedure can be used (for reviews, see [83,84]). These techniques are made more accessible by the introduction of multi-modality systems (PET or SPECT combined with CT or MRI), reducing the need for image co-registration (for recent reviews, see [55,[85][86][87]). These techniques also open the door for methods in which PET data are used to improve the quality of MRI images [88].…”

Section: Noise Controlmentioning

confidence: 99%

Advances in clinical molecular imaging instrumentation

Hutton

Erlandsson

Thielemans

2018

Clin Transl Imaging

Self Cite

View full text Add to dashboard Cite

In this article, we describe recent developments in the design of both single-photon emission computed tomography (SPECT) and positron emission tomography (PET) instrumentation that have led to the current range of superior performance instruments. The adoption of solid-state technology for either complete detectors [e.g., cadmium zinc telluride (CZT)] or read-out systems that replace photomultiplier tubes [avalanche photodiodes (APD) or silicon photomultipliers (SiPM)] provide the advantage of compact technology, enabling flexible system design. In SPECT, CZT is well suited to multi-radionuclide and kinetic studies. For PET, SiPM technology provides MR compatibility and superior time-of-flight resolution, resulting in improved signal-to-noise ratio. Similar SiPM technology has also been used in the construction of the first SPECT insert for clinical brain SPECT/MRI.

show abstract

“…20160690). 4 PET has, since its foundation, established itself as an important imaging modality enabling the quantitative assessment of molecular targets in vivo. PET quantification makes it possible to establish a link between the timevarying activity concentration in relevant organs/tissues and the fundamental parameters standing for the biological processes at the cellular level being assessed.…”

mentioning

confidence: 99%