Development of Co₃[Co(CN)₆]₂/Fe₃O₄ Bifunctional Nanocomposite for Clinical Sensor Applications

Abstract

In this study, a magnetically separable threedimensional (3D) Co 3 [Co(CN) 6 ] 2 /Fe 3 O 4 nanocomposite comprising magnetic nanoparticles (NPs) adsorbed on the nanocubes of a cobalt Prussian blue analogue was prepared. The nanocomposite exhibited enhanced electrochemical performance in Co 2+ /Co 3+ conversion, while the superparamagnetic behavior of the magnetite NPs was preserved even after adsorption on the nanocubes. Increased Faradaic currents were observed in the cyclic voltammograms (CV) for Co 3 [Co(CN) 6 ] 2 /Fe 3 O 4 in comparison with the CV of isolated Co 3 [Co(CN) 6 ] 2 . This increase was attributed to supramolecular charge transfer between the cobalt Prussian blue analogue and the magnetic NPs and the larger amount of electroactive species on the electrode. Transmission electron microscopy images showed well-defined Co 3 [Co(CN) 6 ] 2 nanocubes that had edge lengths of 21−140 nm and were decorated with spherical magnetite NPs less than 10 nm in diameter. Interestingly, an intimate contact between the nanocubes and aggregate formation was avoided by Fe 3 O 4 NPs. The composition, morphology, and surface properties of the nanohybrid material were assessed by UV−vis absorption spectroscopy, FTIR spectroscopy, X-ray diffraction, scanning electron microscopy, and Brunauer−Emmett−Teller surface area. The analytical results of nanocomposite showed main bands, crystalline phases, and structures associated with Fe 3 O 4 and Co 3 [Co(CN) 6 ] 2 . The bifunctional properties of Co 3 [Co(CN) 6 ] 2 /Fe 3 O 4 are potentially useful for building novel (bio)sensors and magnetic devices for clinical applications.

Cucurbit[6]uril-Supported Fe3O4 Magnetic Nanoparticles Catalyzed Green and Sustainable Synthesis of 2-Substituted Benzimidazoles via Acceptorless Dehydrogenative Coupling

“…The presence of Fe 3+ and Fe 2+ ions confirmed the formation of the Fe 3 O 4 spinel on the CB[6] support. Two small humps observed at 719.0 and 731.0 eV show the existence of weak satellites, which further confirmed the presence of mixed oxides of iron. , …”

“…Two small humps observed at 719.0 and 731.0 eV show the existence of weak satellites, which further confirmed the presence of mixed oxides of iron. 85 , 86 …”

A Novel Polydopamine Grafted 3D MOF Nanocubes Mediated GR-5/GC DNAzyme Complex with Enhanced Fluorescence Emission Response toward Spontaneous Detection of Pb(II) and Ag(I) Ions

“…As shown in (f), the peak at 531.5 eV was assigned to the lattice oxide oxygen of the metal oxides. The metal–oxygen (Mn–O) bond formation on the external surface is readily established by the XPS spectrum. , …”

Correction to: Magnetic-core@dual-functional-shell nanocomposites with peroxidase mimicking properties for use in colorimetric and electrochemical sensing of hydrogen peroxide

“…As shown in Fig. S1b for the XPS results, the peaks of Fe (725.1 eV and 710.1 eV for Fe 2p 1/2 and Fe 2p 3/2 , respectively), C (284 eV), N (397.8 eV), and O (530.1 eV) represented the presence of Fe 3 O 4 and PB in both MNP@Au-PB and MNP@PB [37,38]. Specially for MNP@Au-PB, two doublet peaks are observed with maxima at 84.1 eVand 88.1 eV, which are assigned to the 4f 7/2 and 4f 5/2 core levels of Au 0 , indicating the presence of Au [39,40].…”