Development of concepts of etiology, pathogenesis and treatment of pemphigus vulgaris based on the hypothesis of atavistic origin of the disease

Grando, S. A.

doi:10.1016/0306-9877(91)90162-r

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…Pemphigus vulgaris is a rare chronic potentially fatal autoimmune disease whose manifestations are blisters and erosive eruptions on the skin and mucosal membranes (24,25). Although systemic corticosteroid is the building block of the treatment but chronic usage of it will face the patient with severe complications.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the adjuvant effect of tacrolimus in the management of pemphigus vulgaris: A randomized controlled trial

Dastgheib

Sadati

Baghernejhad

2014

Journal of Dermatological Treatment

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Section: Discussionmentioning

confidence: 99%

Assessment of the adjuvant effect of tacrolimus in the management of pemphigus vulgaris: A randomized controlled trial

Dastgheib

Sadati

Baghernejhad

2014

Journal of Dermatological Treatment

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“…This concept is part of an “atavist” hypothesis of pemphigus vulgaris based on the mechanism of shedding in reptiles [75, 76]. …”

Section: Influence Of the Second Form Of Evolutionary Memory In Aumentioning

confidence: 99%

The Biological Significance of Evolution in Autoimmune Phenomena

Cañas

2012

Autoimmune Diseases

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It is an inherent part of living to be in constant modification, which are due to answers resulting from environmental changes. The different systems make adaptations based on natural selection. With respect to the immune system of mammals, these changes have a lot to do with the interactions that occur continuously with other living species, especially microorganisms. The immune system is primarily designed to defend from germs and this response triggers inflammatory reactions which must be regulated in order not to generate damage to healthy tissue. The regulatory processes were added over time to prevent such damage. Through evolution the species have stored “an immunological experience,” which provides information that is important for developing effective responses in the future. The human species, which is at a high level of evolutionary immunological accumulation, have multiple immune defense strategies which, in turn, are highly regulated. Imbalances in these can result in autoimmunity.

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Activation of keratinocyte muscarinic acetylcholine receptors reverses pemphigus acantholysis

Grando

Dahl

1993

Acad Dermatol Venereol

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We studied neuroendoerine mediator regulation of adhesion and motility of human epidermal keratinocytes (EK) and found that eholinergic compounds eontrol EK cell-matrix and ceil-cell attachment. In this study, we tested the anti-acantholytie activity of muscarinic agonists in pemphigus and non-pemphigus acantholysis, and investigated the effects of pemphigus antibody (Pab) on the the keratinocyte muscarinic acetylchohne receptors (mAChR). Acantholysis produced by Pab from two patients with pemphigus vulgaris was compared with acantholysis induced by the serinc protease trypsin, the calcium ehelator EDTA or the musearinic antagonist atropine. Trypsinized EK first lost contact with microplate surfaee and then retraeted their intercellular filaments. EDTA-treated cells first detached from eaeh other and then from the dish. EK cultures treated with Pab or atropine rounded up and retracted their intercellular filaments simultaneously, although it took hours to obtain acantholysis with Pab treatment compared to several seconds with atropine treatment. Addition of aeetylcholine or other musearinie agonists (bethanechol, carbachol or methacholine) to acanthoiytic cultures reversed both pemphigus and non-pemphigus aeantholysis. Acantholysis induced by atropine reversed spontaneously. Short-term precxposure of EK to Pab significantly increased, and long-term preexposure significantly decreased, the [^H]atropine binding to keratinocyte mAChR. We conelude that musearinie agonists reverse various types of acantholysis, including aeantholysis induced by Pab, and that binding of Pab to EK may affect the ability of keratinocyte mAChR to bind its ligands.

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Development of concepts of etiology, pathogenesis and treatment of pemphigus vulgaris based on the hypothesis of atavistic origin of the disease

Cited by 3 publications

References 33 publications

Assessment of the adjuvant effect of tacrolimus in the management of pemphigus vulgaris: A randomized controlled trial

Assessment of the adjuvant effect of tacrolimus in the management of pemphigus vulgaris: A randomized controlled trial

The Biological Significance of Evolution in Autoimmune Phenomena

Activation of keratinocyte muscarinic acetylcholine receptors reverses pemphigus acantholysis

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