Development of concomitant diseases in COVID-19 critically ill patients

Puig, Gabriel Beltrán; Giménez-Milà, Marc; Campistol, E.; Cano, Valverde; Valcárcel, J.

doi:10.1016/j.redare.2020.09.001

Cited by 7 publications

(7 citation statements)

References 10 publications

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“…The detection of viral RNA in the bile wall and gallbladder further supports this hypothesis. Other possible mechanisms include inflammation due to cytokine release syndrome, ischemia due to hypercoagulability, and thrombotic microangiopathy due to SARS-CoV-2 infection [ 19 , 20 , 21 , 22 , 23 ]. However, all the aforementioned findings are just hypotheses of a possible relationship between COVID-19 and AAC, since there are no large studies with robust data supporting a definite causal relationship between these two pathologies.…”

Section: Biliary Manifestations Of Covid-19mentioning

confidence: 99%

“…Several reports in the literature have described the presentation of acute cholecystitis in COVID-19 patients, with most of them being case reports and letters to the editor and some case series ( Table 1 ) [ 10 , 19 , 20 , 21 , 22 , 91 , 92 , 94 , 95 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 ].…”

Section: Worldwide Cases Of Aac In Covid-19mentioning

confidence: 99%

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Acalculous Cholecystitis in COVID-19 Patients: A Narrative Review

Thomaidou,

Karlafti,

Didagelos

et al. 2024

Viruses

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Acute acalculous cholecystitis (AAC) represents cholecystitis without gallstones, occurring in approximately 5–10% of all cases of acute cholecystitis in adults. Several risk factors have been recognized, while infectious diseases can be a cause of cholecystitis in otherwise healthy people. Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has spread worldwide, leading to an unprecedented pandemic. The virus enters cells through the binding of the spike protein to angiotensin-converting enzyme 2 (ACE2) receptors expressed in many human tissues, including the epithelial cells of the gastrointestinal (GI) tract, and this explains the symptoms emanating from the digestive system. Acute cholecystitis has been reported in patients with COVID-19. The purpose of this review is to provide a detailed analysis of the current literature on the pathogenesis, diagnosis, management, and outcomes of AAC in patients with COVID-19.

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Section: Biliary Manifestations Of Covid-19mentioning

confidence: 99%

Section: Worldwide Cases Of Aac In Covid-19mentioning

confidence: 99%

Acalculous Cholecystitis in COVID-19 Patients: A Narrative Review

Thomaidou,

Karlafti,

Didagelos

et al. 2024

Viruses

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“…There have been reports of acute cholecystitis in COVID-19 patients, most of whom were critically ill. Most reported cases of cholecystitis associated with COVID-19 were acalculous cholecystitis, which occurs due to the hypomobility of the gall bladder, and is seen in critically ill patients with sepsis and mechanically ventilated [69][70][71][72][73]. Given the broad expression of ACE2 in human tissues, including in the liver, gallbladder, and bile ducts, there is a possibility of the virus playing a primary role in the development of cholecystitis via direct invasion and replication in the gall bladder and bile ducts.…”

Section: Biliary Manifestations Of Covid-19mentioning

confidence: 99%

Impact of COVID-19 on the Gastrointestinal Tract: A Clinical Review

Ghazanfar¹,

Kandhi²,

Shin³

et al. 2022

Cureus

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Coronavirus disease 2019 (COVID-19) has spread rapidly throughout the world, causing a pandemic that has resulted in more than 5 million deaths globally. The gastrointestinal (GI) tract is known to have high expression of angiotensin-converting enzyme 2 (ACE2) receptors in the human body, making it prone to direct damage from the cellular invasion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Numerous GI symptoms have been reported among patients with COVID-19. This systemic review details the mechanism and effects of COVID-19 on the GI tract along with the hepatobiliary and pancreatic systems.

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“…Finally, they were discharged, once the absence of SARS-CoV-2 was confirmed by RT-PCR at 8 and 12 days after admission, respectively. SARS-type coronaviruses mediate their intracellular entry through the receptor for angiotensin converting enzyme 2 (ACE-2), which is present in various tissues such as the lung, liver or the gallbladder [1][2][3]. TMPRSS2 co-receptor is also essential for viral entry, and it is widely found in gallbladder tissue [4,5].…”

mentioning

confidence: 99%

“…but diarrhea and abdominal pain are the main symptoms from the digestive point of view [ 1 ]. Acalculous cholecystitis has been reported as an uncommon complication following severe COVID-19 pneumonia [ 2 ]. We report two cases of patients with SARS-CoV-2 infection without any respiratory compromise but being diagnosed of acalculous cholecystitis.…”

mentioning

confidence: 99%