Development of D.M. Zubairov ideas by the Chita school of hemostasis

Ильич, Кузник Борис

doi:10.17750/kmj2015-709

Cited by 4 publications

(2 citation statements)

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“…Neutrophil granules contain multiple hydrolytic enzymes, which can have a devastating effect on a plurality of different protein substrates, including fibrin and during the excessive secretion of phagocytic neutrophils [24]. The leading role in the destruction of the protein-native structure belongs to serine protease because it shows broad substrate specificity.…”

Section: Discussionmentioning

confidence: 99%

“…The group with a critically low “Response” has also been noted to have the highest D-dimer concentration ( p < 0.05), which is the end-product of cross-linked fibrin degradation and is within the scope of the proposed hypothesis ( Table 2 ). Neutrophil granules contain multiple hydrolytic enzymes, which can have a devastating effect on a plurality of different protein substrates, including fibrin and during the excessive secretion of phagocytic neutrophils [ 24 ]. The leading role in the destruction of the protein-native structure belongs to serine protease because it shows broad substrate specificity.…”

Section: Discussionmentioning

confidence: 99%

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The Level of Oxidative Neutrophil Response When Determining Endotoxin Activity Assay: A New Biomarker for Defining the Indications and Effectiveness of Intensive Care in Patients with Sepsis

Yaroustovsky

Rogalskaya

Plyushch

et al. 2017

International Journal of Inflammation

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Background. To analyse the clinical informativity of the neutrophil oxidative response level (“Response”) during an Endotoxin Activity Assay (EAA) as a new biomarker defining the indications and effectiveness of intensive care in cardiac surgical patients with septic complications. Methods. Blood samples were taken from 198 adult patients who were admitted to the ICU after cardiac surgery (SIRS: 34, MODS: 36, and sepsis: 128). The composite of laboratory studies included CRP, PCT, EAA with “Response” level, and presepsin. Results. 83% of patients had a “normal” neutrophil response, 12% of patients had a low neutrophil response, and 5% of patients had a critically low neutrophil response. Patients with critically low responses had the lowest values of the EAA and the highest concentrations of PSP and D-dimer (p < 0.05). Conclusions. EAA results should be interpreted with the level of neutrophil response. “Response” > 0.5 has a negative predictive value; the EAA < 0.6 at “Response” < 0.5 may indicate a high level of endotoxaemia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Level of Oxidative Neutrophil Response When Determining Endotoxin Activity Assay: A New Biomarker for Defining the Indications and Effectiveness of Intensive Care in Patients with Sepsis

Yaroustovsky

Rogalskaya

Plyushch

et al. 2017

International Journal of Inflammation

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The Role of Lungs in Balance of the Hemostasis System in the Chronic Exposure to Air Pollutants

Golubkina¹,

Дюкарева²,

Dyukareva³

et al. 2018

Bulletin Physiology and Pathology of Respiration

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The aim of the study is to determine the nature of the consequences of non-respiratory lung function disorders and their influence on the hemostatic system in chronic inhalation of industrial hydrogen sulfide gas (HS). There were studied the parameters of hemostasis system (the number and function of platelet, total clotting time, level of soluble fibrin-monomer complex and D-dimer, speed of XIIa-dependent euglobulin lysis, the activity of Willebrand factor and factors VIII, protein C and inhibitor of tissue plasminogen activator-1 (TPA-1), the content of antithrombin III and plasminogen) in 146 white laboratory male rats taking into account the artery-venous difference. Blood collection was carried out from the abdominal aorta (pars abdominalis aortae) ("after the lungs") and from the posterior vena cava (vena cava caudalis) ("to the lungs", that excludes the influence of the liver). The rats were divided into 9 groups: four groups were experimental, which were exposed to HS for one month (20 animals), two months (20 animals), three months (19 animals) and four months (19 animals). HS was fed into chambers at a concentration of 70±2.34 mg/m3 by static method (once). Inhalation of rats with gas lasted for 4 hours a day, 5 days a week. The control groups were rats placed in cells with a normal air composition in a similar mode for a period of one, two, three and four months (12 individuals each). The reference parameters of the hemostatic system were determined before the experiment in a group of 20 rats. It was found that the artery-venous difference in the indicators of soluble fibrin-monomer complex (p<0.05), the content of antithrombin III (p<0.05), the activity of protein C (p<0.01) is more pronounced in the groups of the 1st month of exposure to HS. Increased activity of platelets (p<0.05), of Willebrand factor (p<0.05) and TPA-1 (p<0.001), as well as slowing of fibrinolysis (p<0.05) indicates the damage to the endothelium of pulmonary capillaries by the 4th month of HS inhalation and the decrease of ability of the lungs to regulate hemostasiological balance.

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Pathogenic peculiarities of disseminated intravascular coagulation of various ethiology

Гузовская¹,

Серебренникова²

2017

ZHurnal «Patologicheskaia Fiziologiia I Eksperimental`naia Terapiia»

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ДВС-синдром - тяжелое осложнение, часто приводящее к полиорганной недостаточности и нередко к летальному исходу. Как и любой синдром, он полиэтиологичен, что закономерно приводит к различным механизмам его формирования. Основные проявления синдрома диссеминированного внутрисосудистого свертывания крови - тромбообразование и кровоточивость. Следствием массивного тромбообразования в микроциркуляторном русле внутренних органов является развитие дистрофических изменений и органной недостаточности. Кровотечения, в свою очередь, приводят к уменьшению объема циркулирующей крови, артериальной гипотензии и гемической гипоксии, а в наиболее тяжелых случаях - и к летальному исходу. Однако механизмы развития и степень выраженности вышеуказанных нарушений далеко не всегда одинаковы. Поскольку данный синдром может быть обусловлен большим количеством причин (в настоящее время описано более 150 заболеваний, при которых может развиваться синдром), то наибольшим разнообразием отличаются именно инициальные его звенья. Основными пусковыми механизмами ДВС-синдрома могут быть: активация форменных элементов крови и усиление процесса их микровезикуляции, активация коагуляционного гемостаза по внешнему и внутреннему путям, недостаточность антикоагулянтов и избыточная активность фибринолитической системы. Разные этиологические факторы (сепсис, акушерская патология, лейкозы и другие злокачественные опухоли, травмы и т.д) неодинаково влияют на функцию компонентов системы гемостаза. В зависимости от степени выраженности нарушений вышеуказанных механизмов может развиться ДВС-синдром с преобладанием коагуляции или с преобладанием фибринолиза либо с их сбалансированной активацией. Клинические проявления этих форм ДВС-синдрома, а также продолжительность и выраженность стадий (гиперкоагуляция, коагулопатия потребления с компенсаторной активацией фибринолиза, дефибринация крови и гиперактивация фибринолиза) также будут отличаться. Следовательно, знание преобладающего нарушения в системе гемостаза при наличии заболевания, потенциально опасного в плане развития ДВС-синдрома, позволит подобрать наиболее оптимальные способы его профилактики, диагностики и лечения. DIC is a severe complication, often resulting in multi-organ failure and fatal outcome. As any syndrome, it is polyethiologic, while a big number of its causes logically leads to various mechanisms of its forming. Main manifestations of the disseminated intravascular blood coagulation syndrome are clottage and haemorrhage. A result of a massive clottage in microcirculatory bed of internal organs is development of dystrophic changes in them and organ failure. Haemorrhage in its turn, results in decreased volume of circulating blood, arterial hypotension and hemic hypoxia, in most severe cases leading to the fatal outcome. Although, development mechanisms and manifestation degree of the disorder mentioned above are not always the same. As the syndrome may result from a great number of causes (currently, over 150 diseases have been described with which it can develop), namely its initial stages are different to the greatest extent. Main triggering mechanisms of the DIC may be: blood formed element activation and increased process of their microvesiculation, activation of coagulative hemostasis in intrinsic and extrinsic pathways, lack of anticoagulants and excessive activity of fibrinolytic system. Various ethiologic factors (sepsis, obstetrical pathology, leucosis and other malignant tumours, traumas, etc) have different effect on function of hemostasis system components. Depending on the degree of the above mentioned disorders mechanisms manifestation, the DIC may develop with prevailing coagulation, with prevailing fibrinolysis or with their balanced activation. Clinical manifestations of these DIC forms, as well as duration and manifestation degree of its stages (hypercoagulation, coagulopathy of consumption with compensatory activation of fibrinolysis, defibrination of the blood and excessive activation of fibrinolysis) will be different as well. Consequently, knowing the prevailing disorder in hemostasis system during a disease that is potentially dangerous in terms of the DIC development offers to find optimal methods of its prevention, diagnosing and treatment.

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Development of D.M. Zubairov ideas by the Chita school of hemostasis

Cited by 4 publications

References 0 publications

The Level of Oxidative Neutrophil Response When Determining Endotoxin Activity Assay: A New Biomarker for Defining the Indications and Effectiveness of Intensive Care in Patients with Sepsis

The Level of Oxidative Neutrophil Response When Determining Endotoxin Activity Assay: A New Biomarker for Defining the Indications and Effectiveness of Intensive Care in Patients with Sepsis

The Role of Lungs in Balance of the Hemostasis System in the Chronic Exposure to Air Pollutants

Pathogenic peculiarities of disseminated intravascular coagulation of various ethiology

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