Development of daidzein nanosuspensions: Preparation, characterization, in vitro evaluation, and pharmacokinetic analysis

Wang, Hui; Xiao, Yi; Wang, Hai; Sang, Zechun; Han, Xiaole; Ren, Shuzhen; Du, Ruofei; Shi, Xiufeng; Xie, Yan

doi:10.1016/j.ijpharm.2019.05.051

Cited by 48 publications

(18 citation statements)

References 52 publications

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“…The mean P.Ss and PDI values are shown in Table (2). A PDI value < 0.3 indicates a narrow size distribution, while PDI >0.3 is considered a broad size distribution (20) .…”

Section: Ps and Pdi Analysismentioning

confidence: 99%

“…The liquid solvent antisolvent precipitation method was used to formulate SLPNS in the presence of stabilizer alone (PVA, HPMC E15, Soluplus®, and PX-407) and in combination with co-stabilizer (tween-80, which is a nonionic surfactant that sterically stabilized the system) to study the effect of polymer-surfactant interaction on the P.S as shown in Figure (2).…”

Section: Effect Of the Addition Of Co-stabilizer On The Psmentioning

confidence: 99%

“…Nanosuspensions (NS) is defined as a unique submicron colloidal dispersion of nanosized drug particles that need to be stabilized by suitable stabilizers (polymer and/or surfactant) (2) . Currently, NS has been considered as an attractive approach for enhancing the bioavailability of insoluble drugs owing to increase their saturation solubility and dissolution rate (3) .…”

Section: Introductionmentioning

confidence: 99%

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Nanosuspensions of Selexipag: Formulation, Characterization, and in vitro Evaluation

Alwan¹,

Rajab²

2021

IJPS

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Selexipag is an orally selective long-acting prostacyclin receptor agonist, which indicated for the treatment of pulmonary arterial hypertension. It is practically insoluble in water ( class II, according to BCS). This work aims to prepare and optimized Selexipag nanosuspensions to achieve an enhancement in the in vitro dissolution rate. The solvent antisolvent precipitation method was used for the production of nanosuspension, and the effect of formulation parameters (stabilizer type, drug: stabilizer ratio, and use of co-stabilizer) and process parameter (stirring speed) on the particle size and polydispersity index were studied. SLPNS prepared with Soluplus® as amain stabilizer (F15) showed the smallest particle size 47nm with PDI and Zeta potential value of 0.073 and -47mV, respectively. SLPNS exhibited an increase in the dissolution rate in phosphate buffer pH 6.8 (100% drug release during 60 min) compared to the pure drug ( 40% during the same time). This result indicates that SLPNS is an efficient way of improving the dissolution rate.

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“…The mean P.Ss and PDI values are shown in Table (2). A PDI value < 0.3 indicates a narrow size distribution, while PDI >0.3 is considered a broad size distribution (20) .…”

Section: Ps and Pdi Analysismentioning

confidence: 99%

Section: Effect Of the Addition Of Co-stabilizer On The Psmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nanosuspensions of Selexipag: Formulation, Characterization, and in vitro Evaluation

Alwan¹,

Rajab²

2021

IJPS

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“…Figure 3 gives a schematic description of the two different mechanisms. In addition, the selected stabilizer could also have influence on the bioavailability and a recent study in 2019 found that combination of ionic surfactant and polymer could highly contribute to the bioavailability (Wang et al., 2019). Some stabilizers such as TPGS and poloxamers are P-gp inhibitors and could reverse the drug resistance (Tuomela et al., 2016).…”

Section: Tailor-made Drug Delivery Based On Nanocrystalsmentioning

confidence: 99%

Advanced modification of drug nanocrystals by using novel fabrication and downstream approaches for tailor-made drug delivery

Liu

Yin

et al. 2019

Drug Delivery

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Drug nanosuspensions/nanocrystals have been recognized as one useful and successful approach for drug delivery. Drug nanocrystals could be further decorated to possess extended functions (such as controlled release) and designed for special in vivo applications (such as drug tracking), which make best use of the advantages of drug nanocrystals. A lot of novel and advanced size reduction methods have been invented recently for special drug deliveries. In addition, some novel downstream processes have been combined with nanosuspensions, which have highly broadened its application areas (such as targeting) besides traditional routes. A large number of recent research publication regarding as nanocrystals focuses on above mentioned aspects, which have widely attracted attention. This review will focus on the recent development of nanocrystals and give an overview of regarding modification of nanocrystal by some new approaches for tailor-made drug delivery.

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“…In this method we need to majorly focus on the two parameters called pressure and homogenization cycles [44]. Hui wang et al has formulated daidzein nanosuspension via high-pressure homogenization technique by using stearic and electrostatic stabilizers to have improved solubility and oral bioavailability [45]. Alptug Karakucuk et al has prepared Ritonavir nanosuspension via high-pressure homogenization using microfluidizer with HPMC 3 cps and sodium dodecyl sulfate as stabilizers resulted in improved oral bioavailability in fed state [46].…”

Section: High-pressure Homogenizationmentioning

confidence: 99%

A a Review on the Role of Nanocrystals and Nanosuspensions in Drug Delivery Systems

et al. 2019

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Nearly 40% of drugs coming to the market nowadays are having poor solvency related issues and 70% molecules in the discovery pipeline are in effect fundamentally insoluble in water. Nanocrystals is an unmistakable instrument to tackle the issue identified with poor fluid solvency and helps in improving the bioavailability of various drugs as presented in the literature. The particle size reduction came about into the temperamental nanocrystalline system and the phenomenon of ostawald ripening happens. These techniques are preparing to the improvement of nanosized objects, which can play out multiple technological tasks. There are a few couples of noteworthy benefits of nanocrystal formulations, for example, upgrade oral bioavailability, improved dose proportionality, reduced food effects, appropriateness for administration by all routes and probability of sterile filtration because of diminished particle size range. One of the most adequate preferences of nanocrystals is their wide scope of utilization, for example, ophthalmic delivery, oral delivery, transdermal delivery, pulmonary delivery, intravenous delivery and targeted delivery, especially for tumour and brain. The increment in the commercial value of nanocrystals just as the measure of nanocrystal products in the market is picking up more of attention to be utilized as a strategy so as to get commercial advantages. In this paper, a brief and accurate precis of nanosuspension is stated with a specific spotlight on nanosuspension preparation methodologies, benefits and few major applications of nanosuspensions. I In nt te er rn na at ti io on na al l J Jo ou ur rn na al l o of f A Ap pp pl li ie ed d P Ph ha ar rm ma ac ce eu ut ti ic cs s

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Development of daidzein nanosuspensions: Preparation, characterization, in vitro evaluation, and pharmacokinetic analysis

Cited by 48 publications

References 52 publications

Nanosuspensions of Selexipag: Formulation, Characterization, and in vitro Evaluation

Nanosuspensions of Selexipag: Formulation, Characterization, and in vitro Evaluation

Advanced modification of drug nanocrystals by using novel fabrication and downstream approaches for tailor-made drug delivery

A a Review on the Role of Nanocrystals and Nanosuspensions in Drug Delivery Systems

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