Development of Daptomycin Resistance In Vivo in Methicillin-Resistant
            <i>Staphylococcus aureus</i>

Hayden, Mary K.; Rezai, Katayoun; Hayes, Robert A.; Lolans, Karen; Quinn, John P.; Weinstein, Robert A.

doi:10.1128/jcm.43.10.5285-5287.2005

Cited by 226 publications

(146 citation statements)

References 7 publications

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“…Daptomycin is a cyclic lipopeptide derived from Streptomyces roseosporus. Reduced daptomycin susceptibility in S. aureus was reported to emerge during therapy and appears to be associated with high-bacterial-load infections (87,110,116,191,198). In some cases resistance appears to be associated with mutations in mprF and yycG, loci which have been implicated in reduced vancomycin susceptibility in some strains.…”

Section: Potentially Active Antimicrobials Currently Availablementioning

confidence: 99%

Reduced Vancomycin Susceptibility inStaphylococcus aureus, Including Vancomycin-Intermediate and Heterogeneous Vancomycin-Intermediate Strains: Resistance Mechanisms, Laboratory Detection, and Clinical Implications

et al. 2010

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SUMMARY The emergence of vancomycin-intermediate Staphylococcus aureus (VISA) and heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) over the past decade has provided a challenge to diagnostic microbiologists to detect these strains, clinicians treating patients with infections due to these strains, and researchers attempting to understand the resistance mechanisms. Recent data show that these strains have been detected globally and in many cases are associated with glycopeptide treatment failure; however, more rigorous clinical studies are required to clearly define the contribution of hVISA to glycopeptide treatment outcomes. It is now becoming clear that sequential point mutations in key global regulatory genes contribute to the hVISA and VISA phenotypes, which are associated predominately with cell wall thickening and restricted vancomycin access to its site of activity in the division septum; however, the phenotypic features of these strains can vary because the mutations leading to resistance can vary. Interestingly, changes in the staphylococcal surface and expression of agr are likely to impact host-pathogen interactions in hVISA and VISA infections. Given the subtleties of vancomycin susceptibility testing against S. aureus, it is imperative that diagnostic laboratories use well-standardized methods and have a framework for detecting reduced vancomycin susceptibility in S. aureus.

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Section: Potentially Active Antimicrobials Currently Availablementioning

confidence: 99%

Reduced Vancomycin Susceptibility inStaphylococcus aureus, Including Vancomycin-Intermediate and Heterogeneous Vancomycin-Intermediate Strains: Resistance Mechanisms, Laboratory Detection, and Clinical Implications

et al. 2010

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“…The mechanisms underlying daptomycin resistance are not well understood (19) (20) , but it is known that decreased susceptibility to daptomycin and vancomycin can co-occur both in vivo (20) and in vitro (21) after selection with either antimicrobial (21) . Although there is evidence for cross-resistance (21) , in this study, the hDRSA isolate remained susceptible to vancomycin.…”

Section: Discussionmentioning

confidence: 99%

Molecular analysis of methicillin-resistant Staphylococcus aureus dissemination among healthcare professionals and/or HIV patients from a tertiary hospital

Okado

Bogni

Reinato

et al. 2016

Rev. Soc. Bras. Med. Trop.

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“…Gram pozitif aerop ve anaerop bakteri grupları üzerine hızlı bakterisidal etkinliğe sahiptir. Metisiline dirençli stafilokok türleri, glikopeptidlere orta duyarlı S. aureus, penisilin dirençli Streptococcus pneumoniae ve vankomisine dirençli enterokokları (VRE) da içine alan geniş çapta etkinliği vardır (7)(8)(9)(10) . Daptomisin, oligorimerizasyon ile hücre zarı bütünlüğünü bozar, depolarizasyon sonucu sitoplazma zarı işlevini kaybeder ve hücre hızla ölür.…”

Section: Introductionunclassified

In Vitro Daptomycin and Linezolid Susceptibility Profiles of Enterococcus faecium and Enterococcus faecalis Strains Isolated from Blood Cultures

Öcal¹,

Gürbüz²,

Dansuk³

et al. 2017

TMCD

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Kan Kültürlerinden İzole Edilen Enterococcus faecium ve ABSTRACT In vitro Daptomycin and Linezolid Susceptibility Profiles of Enterococcus faecium and Enterococcus faecalis Strains Isolated from Blood Cultures Objective: Enterococcal infections are among the leading causes of health care-associated infections, and in the treatment of these infections gradually increasing rate of antimicrobial resistance issue is encountered all over theworld. Resistance to glycopeptides and high-level aminoglycosides also increases the use of antibiotics such as linezolid and daptomycin against resistant gram-positive bacteria. Detection of in vitro efficacies of daptomycin and linezolid against Enterococcus faecium and Enterococcus faecalis strains isolated from blood cultures was aimed in this study Material and Methods

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Development of Daptomycin Resistance In Vivo in Methicillin-Resistant Staphylococcus aureus

Cited by 226 publications

References 7 publications

Reduced Vancomycin Susceptibility inStaphylococcus aureus, Including Vancomycin-Intermediate and Heterogeneous Vancomycin-Intermediate Strains: Resistance Mechanisms, Laboratory Detection, and Clinical Implications

Reduced Vancomycin Susceptibility inStaphylococcus aureus, Including Vancomycin-Intermediate and Heterogeneous Vancomycin-Intermediate Strains: Resistance Mechanisms, Laboratory Detection, and Clinical Implications

Molecular analysis of methicillin-resistant Staphylococcus aureus dissemination among healthcare professionals and/or HIV patients from a tertiary hospital

In Vitro Daptomycin and Linezolid Susceptibility Profiles of Enterococcus faecium and Enterococcus faecalis Strains Isolated from Blood Cultures

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