Development of Digestive Enzymes in the Piglet from Birth to 8 Weeks

Aumaı̂tre, A.; Corring, T.

doi:10.1159/000300539

Cited by 47 publications

(42 citation statements)

References 13 publications

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“…In contrast to our findings in miniature pigs, full-size pigs have been shown to have significant rises (2-to 3-fold) in jejunal sucrase activity after birth (9,11). In a study by Aumatire and Coming (9), jejunal maltase activity in full-size pigs rose between birth and one week and then fell somewhat between 2 and 4 wk.…”

Section: Discussioncontrasting

confidence: 99%

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The Miniature Pig as an Animal Model for the Study of Intestinal Enzyme Development

1988

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ABSTRAm. Studies of intestinal enzyme development and regulation relevant to the human infant require an animal model with a rate of maturation similar to that of the human infant. Hanford miniature pigs were weaned at 3 days of age to a standard swine weaning formula. At 1, 2, 3, 4, 5, and 6 wk of age, duodenal jejunal, and ileal segments were analyzed for protein content and lactase, sucrase, maltase, glucoamylase, and acid P-galactosidase activities. Protein content of the small intestine changed significantly with age only in the ileum ( p < 0.05). Lactase activity fell significantly with age in all segments of the small intestine ( p < 0.001); activity was highest in the jejunum. Sucrase and maltase activities were present in all segments of the small intestine at 1 wk of age. Sucrase increased significantly (2-fold, p < 0.02) with age only in the ileum and maltase increased significantly with age in the jejunum (by 50%, p < 0.05) and the ileum (3-fold, p < 0.001). Activities were highest in the jejunum. Glucoamylase activity was present at 1 wk of age and showed a small but significant increase with age only in the duodenum ( p < 0.005). Acid 8-galactosidase activity demonstrated small but significant decreases with age in all small intestinal segments. Glucoamylase and acid 0-galactosidase activities were similar in all segments. In the 6-wk-old pigs, activities of all the enzymes tested were similar to those found in young human infants. Our data demonstrate that the small intestinal enzyme development of the infant miniature pig is more advanced postnatally than other more commonly used animal species. The degree of small intestinal maturation and the similar intestinal enzyme distribution compared with that of the human infant suggest that the infant miniature pig is an excellent model for studies of intestinal enzyme development and regulation. (Pediatr Res 23: 311-315,1988) Abbreviation PCMB, P-chloromercuribenzoate Clinically relevant studies of the development and regulation of intestinal enzymes in the human infant have been hampered

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Section: Discussioncontrasting

confidence: 99%

“…Previous studies of pig intestinal enzyme activity indicate a level of intestinal maturity at birth which is intermediate to that of the species named above and the human (9,10). Much variability has been noted, however, in the rate of maturation of intestinal enzymes in the pig (9)(10)(11)(12).…”

mentioning

confidence: 91%

The Miniature Pig as an Animal Model for the Study of Intestinal Enzyme Development

1988

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“…Similarly, the feeding behaviour before weaning did not affect the post-weaning intestinal capacity to degrade starch or maltose, either estimated through the intraluminal (jejunum or ileum) specific or total activity of amylase or maltase. This was consistent with Corring et al [7] who reported that the pancreatic amylase level was not affected by a shorter sucking period (until 21 [3,23]. Therefore, the development of maltase activity would be mainly controlled by ontogenic factors rather than by nutritional factors.…”

Section: Discussionsupporting

confidence: 89%

Digestive capacity of the rabbit during the post-weaning period, according to the milk/solid feed intake pattern before weaning

Scapinello¹,

Gidenne²,

Fortun-Lamothe³

1999

Reprod. Nutr. Dev.

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-The milk/solid feed intake pattern and digestive capacity were compared in two groups of young rabbits reared between 16 and 32 days in litters of four (L4 group, n = 18 litters) or ten pups (L10, n = 20) in order to modulate milk availability. Compared to the L4 group, rabbits in the LIO group presented a lower milk intake (22.3 versus 28.8 g-day-1 ) and a higher solid feed intake (12.9 versus 8.0 g-day-1 ) between 16 and 32 days of age. Live weight and weight gain were significantly lower in the L10 (-15 %) than in the L4 group from 22 until 42 days. No significant difference was observed among the two groups for post-weaning digestibility and for the intraluminal specific or total activities of amylase and maltase. The total intraluminal activity (pool of enzyme) of amylase and maltase doubled between weaning (32 days) and 42 days. At weaning, the specific activity of amylase was similar in the jejunal and ileal segments (8.5 AU-g-1 ). From 32 to 42 days, the specific amylase activity doubled in the jejunum, while it remained steady in the ileum. The intraluminal specific maltase activity did not significantly change between 32 and 42 days, while it was twice as high in the jejunum compared to the ileum (3.5 versus 1.8 pmoles hydrolysed maltosei-g-1 , respectively

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“…The results of our study are in agreement with previously reported studies (Aumaitre and Corring, 1978;Kidder and Manners, 1980;Shulman et al, 1988), which observed that brush-border sucrase and maltase activity increased with age. Specific activity of lactase reached a maximum at the end of the 1st week after birth and decreased afterwards (Aumaitre and Corring, 1978). Ekstrom et al (1975b) reported that the mean of specific lactase activity was highest at 1 and 8 days of age and then fell progressively to a minimal level at 43 days of age.…”

Section: Discussionsupporting

confidence: 94%

“…The present data revealed that total and specific sucrase and maltase activities increase significantly with age, whereas, specific lactase activity decreases significantly with age, which perhaps reflects the switch in dietary carbohydrate from predominantly lactose to starch after weaning, because of substrate effects on enzyme production in the digestive tract (Adeola and King, 2006). The results of our study are in agreement with previously reported studies (Aumaitre and Corring, 1978;Kidder and Manners, 1980;Shulman et al, 1988), which observed that brush-border sucrase and maltase activity increased with age. Specific activity of lactase reached a maximum at the end of the 1st week after birth and decreased afterwards (Aumaitre and Corring, 1978).…”

Section: Discussionsupporting

confidence: 92%

Developmental changes of jejunal brush-border enzyme activity in growing Jinhua gilts

Miao

LeiJie

Zhu

et al. 2009

Italian Journal of Animal Science

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The present study was aimed to investigate the developmental changes of small intestinal morphometry and jejunal brush-border enzyme activity in growing Jinhua gilts. The weight, length, and mucosa weight of the small intestine were measured at 35, 80 and 125 days of age, respectively. Sucrase, maltase, lactase and alkaline phosphatase (ALP) activities of the jejunal brush-border membrane were determined at the respective stages. Body weights and body weight gains significantly increased with age (P<0.05). Weights of the small intestine and of the intestinal mucosa increased faster from 35 to 80 d than from 80 to 125 d (P<0.05). Weights of the duodenum, jejunum, and ileum, and mucosa from the respective sections increased with age (P<0.05). Mucosa weight relative to the weight of the section was greater (P<0.05) for the duodenum, jejunum than for the ileum. Jejunal maltase and sucrase activity increased with age (P<0.05), whereas, lactose and ALP activity decreased with age (P<0.05) during growth. There was a 15-fold increase in both total jejunal maltase and sucrase activity from 35 to 125 days of age, and a 5-fold increase in both total jejunal lactase and ALP activity; the greatest rate of increase occurred between 35 and 80 days of age. The results suggest increases in body weight of growing Jinhua gilts are accompanied by significant developmental changes in intestinal weight, length and mucosal weights as well as jejunal brush border maltase, sucrase, lactase and ALP activities.

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Development of Digestive Enzymes in the Piglet from Birth to 8 Weeks

Cited by 47 publications

References 13 publications

The Miniature Pig as an Animal Model for the Study of Intestinal Enzyme Development

The Miniature Pig as an Animal Model for the Study of Intestinal Enzyme Development

Digestive capacity of the rabbit during the post-weaning period, according to the milk/solid feed intake pattern before weaning

Developmental changes of jejunal brush-border enzyme activity in growing Jinhua gilts

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