Development of digital breast tomosynthesis and diffuse optical tomography fusion imaging for breast cancer detection

Abstract

Diffuse optical tomography (DOT) non-invasively measures the functional characteristics of breast lesions using near infrared light to probe tissue optical properties. This study aimed to evaluate a new digital breast tomosynthesis (DBT)/DOT fusion imaging technique and obtain preliminary data for breast cancer detection. Twenty-eight women were prospectively enrolled and underwent both DBT and DOT examinations. DBT/DOT fusion imaging was created after acquisition of both examinations. Two breast radiologists analyzed DBT and DOT images independently, and then finally evaluated the fusion images. The diagnostic performance of each reading session was compared and interobserver agreement was assessed. The technical success rate was 96.4%, with one failure due to an error during DOT data storage. Among the 27 women finally included in the analysis, 13 had breast cancer. The areas under the receiver operating characteristic curve (AUCs) for DBT were 0.783 and 0.854 for readers 1 and 2, respectively. DOT showed comparable diagnostic performance to DBT for both readers. The AUCs were significantly improved (P = 0.004) when the DBT/DOT fusion images were used. Interobserver agreements were highest for the DBT/DOT fusion images. In conclusion, this study suggests that DBT/DOT fusion imaging technique appears to be a promising tool for breast cancer diagnosis.

Image reconstruction for diffuse optical tomography using bi‐conjugate gradient and transpose‐free quasi minimal residual algorithms and comparison of them

“…r s indicates the position of the source and r d indicates the position of the detector. Equation ( 6) can be expressed in a discrete form as Equation (7) to create images based on the attenuation over voxels.…”

Differentiating non-lactating mastitis and malignant breast tumors by deep-learning based AI automatic classification system: A preliminary study

“…The breast imaging reporting and date system formulated by the American College of Radiology provided classification criteria for the ultrasound diagnosis of breast diseases (10). There are many clinical diagnostic methods, including nuclear magnetic resonance, tomography, threedimensional reconstruction technology, and ultrasound examination (11)(12)(13)(14)(15). In some cases, due to the limited availability of medical imaging equipment, as well as the less working experience of physicians, misdiagnosis still occurs sometimes, leading to a patient's failure to be diagnosed correctly (16).…”

Approaches to preclinical studies with heterogeneous breast phantom using reconstruction and three‐dimensional image processing algorithms for diffuse optical imaging

“…Those techniques, including MRI, DBT, mammography, and US, have been used together for breast cancer screening. 1 Recently, diffuse optical tomography (DOT) has emerged as vital research to image the inside human body and some organs such as the breast and brain. [2][3][4][5] DOT aims at producing spatially resolved images based on the blood distribution in tissues and provides 6,7 functional images complementary structural information for MRI scans and X-rays.…”

“…Some of the imaging techniques in breast tumor diagnosis are mammography, digital breast tomosynthesis (DBT), positron emission tomography (PET), magnetic resonance imaging (MRI), and ultrasonography (US). Those techniques, including MRI, DBT, mammography, and US, have been used together for breast cancer screening 1 …”