Development of double network polyurethane–chitosan composite bioinks for soft neural tissue engineering

Cheng, Kun-Chih; Sun, Yi-Ming; Hsu, Shan‐hui

doi:10.1039/d3tb00120b

Cited by 12 publications

(6 citation statements)

References 77 publications

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“…TPU is an elastic material with cytocompatible properties that could be used to mimic soft tissues. This enhances biological properties, maintains cell viability, promotes cell proliferation, and differentiates neural stem cells [ 145 ].…”

Section: 3d Cell Culturesmentioning

confidence: 99%

Biomimetic Scaffolds—A Novel Approach to Three Dimensional Cell Culture Techniques for Potential Implementation in Tissue Engineering

Górnicki,

Lambrinow,

Golkar-Narenji

et al. 2024

Nanomaterials

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Biomimetic scaffolds imitate native tissue and can take a multidimensional form. They are biocompatible and can influence cellular metabolism, making them attractive bioengineering platforms. The use of biomimetic scaffolds adds complexity to traditional cell cultivation methods. The most commonly used technique involves cultivating cells on a flat surface in a two-dimensional format due to its simplicity. A three-dimensional (3D) format can provide a microenvironment for surrounding cells. There are two main techniques for obtaining 3D structures based on the presence of scaffolding. Scaffold-free techniques consist of spheroid technologies. Meanwhile, scaffold techniques contain organoids and all constructs that use various types of scaffolds, ranging from decellularized extracellular matrix (dECM) through hydrogels that are one of the most extensively studied forms of potential scaffolds for 3D culture up to 4D bioprinted biomaterials. 3D bioprinting is one of the most important techniques used to create biomimetic scaffolds. The versatility of this technique allows the use of many different types of inks, mainly hydrogels, as well as cells and inorganic substances. Increasing amounts of data provide evidence of vast potential of biomimetic scaffolds usage in tissue engineering and personalized medicine, with the main area of potential application being the regeneration of skin and musculoskeletal systems. Recent papers also indicate increasing amounts of in vivo tests of products based on biomimetic scaffolds, which further strengthen the importance of this branch of tissue engineering and emphasize the need for extensive research to provide safe for humansbiomimetic tissues and organs. In this review article, we provide a review of the recent advancements in the field of biomimetic scaffolds preceded by an overview of cell culture technologies that led to the development of biomimetic scaffold techniques as the most complex type of cell culture.

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Section: 3d Cell Culturesmentioning

confidence: 99%

Biomimetic Scaffolds—A Novel Approach to Three Dimensional Cell Culture Techniques for Potential Implementation in Tissue Engineering

Górnicki,

Lambrinow,

Golkar-Narenji

et al. 2024

Nanomaterials

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“…The resulting PUC composite hydrogels demonstrated a 300% cell proliferation in 7 days and exhibited excellent self-healing properties, as shown in figure 6(c). The authors postulated that the entanglement of colloidal WPU nanospheres in the network plays a role in enhancing the rheological properties of the bioink formulation by increasing electrostatic interaction and forming H-bonds with chitosan molecules [126]. The utilization of self-healing nanocomposites prompts manufacturing industries to decrease waste, and incorporating natural polymers into the production of self-healing composites further supports this endeavor due to their biodegradability, thereby promoting sustainable practices.…”

Section: Self Healing Nanocompositesmentioning

confidence: 99%

“…The interaction contributed to heightened cross-link density, diminished pore sizes, and a consequent enhancement in the mechanical properties of the composite material. The UV-filtering capability of LNP-based Reproduced from [126], with permission from the Royal Society of Chemistry. hydrogel holds promise for various biomedical applications that demand protection against UV light, including potential use in items such as contact lenses or hydrogel wound dressings.…”

Section: Uv Barriersmentioning

confidence: 99%

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Nano-enabled smart and functional materials toward human well-being and sustainable developments

Rajeev,

Yin,

Kalambate

et al. 2024

Nanotechnology

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Fabrication and operation on increasingly smaller dimensions have been highly integrated with the development of smart and functional materials; they are key to many technological innovations to meet economic and societal needs. Along with many researchers worldwide, the Waterloo Institute for Nanotechnology (WIN) has long realized the synergetic interplays between nanotechnology and functional materials and designated “Smart & Functional Materials” as one of its four major research themes. Thus far, WIN researchers have utilized the properties of smart polymers, nanoparticles, and nanocomposites to develop active materials, membranes, films, adhesives, coatings, and devices with novel and improved properties and capabilities. In this review article, we aim to highlight some of the recent developments on the subject including our own research and key research literature in the context of the UN Sustainability development goals.

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“…It can fabricate scaffolds with lattice-like structures, providing weight reduction and ample mechanical strength and stiffness for numerous engineering applications such as automobile, aerospace, and biomedical engineering [ 5 , 6 , 7 ]. Polyurethane (PU) is an important biopolymer widely used in 3D printing applications, especially for coating or as a composite and adhesive material [ 8 , 9 ]. The advantages of PU include low volatility, low solvent content, low odor, low toxicity, low volatile organic compound emissions, and excellent coating effects [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Enhancing the Mechanical Properties and Aging Resistance of 3D-Printed Polyurethane through Polydopamine and Graphene Coating

Tung,

Lin,

Chen

et al. 2023

Polymers

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Three-dimensional (3D) printing is a versatile manufacturing method widely used in various industries due to its design flexibility, rapid production, and mechanical strength. Polyurethane (PU) is a biopolymer frequently employed in 3D printing applications, but its susceptibility to UV degradation limits its durability. To address this issue, various additives, including graphene, have been explored to enhance PU properties. Graphene, a two-dimensional carbon material, possesses remarkable mechanical and electrical properties, but challenges arise in its dispersion within the polymer matrix. Surface modification techniques, like polydopamine (PDA) coating, have been introduced to improve graphene’s compatibility with polymers. This study presents a method of 3D printing PU scaffolds coated with PDA and graphene for enhanced UV stability. The scaffolds were characterized through X-ray diffraction, Fourier-transform infrared spectroscopy, mechanical testing, scanning electron microscopy, and UV durability tests. Results showed successful PDA coating, graphene deposition, and improved mechanical properties. The PDA–graphene-modified scaffolds exhibited greater UV resistance over time, attributed to synergistic effects between PDA and graphene. These findings highlight the potential of combining PDA and graphene to enhance the stability and mechanical performance of 3D-printed PU scaffolds.

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Development of double network polyurethane–chitosan composite bioinks for soft neural tissue engineering

Abstract: Three-dimensional (3D) bioprinting is an emerging manufacturing technology to print materials with cells for tissue engineering applications. In this study, we prepared novel ternary soft segment-based biodegradable polyurethane (tPU) by...

Cited by 12 publications

References 77 publications

Biomimetic Scaffolds—A Novel Approach to Three Dimensional Cell Culture Techniques for Potential Implementation in Tissue Engineering

Biomimetic Scaffolds—A Novel Approach to Three Dimensional Cell Culture Techniques for Potential Implementation in Tissue Engineering

Nano-enabled smart and functional materials toward human well-being and sustainable developments

Enhancing the Mechanical Properties and Aging Resistance of 3D-Printed Polyurethane through Polydopamine and Graphene Coating

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