Development of doxorubicin loading platform based albumin-sporopollenin as drug carrier

Abstract

Albumin is thought as an drug carrier for doxorubicin (DOX). The binding of doxorubicin to albumin was studied on the surface of sporopolleninin (SP) to produce a new drug system based natural materials. Human serum albumin (HSA) was immobilized on SPIONs in 20 mM Tris buffer, 7.4 of pH. Data showed that binding amount of HSA has been found to be as 285.53 µg to the 25 mg of Sporopolleninin which also bounded 319.76 µM of DOX. Binding of protein and drug to Sp were clarified by SEM, EDX and FT-IR analysis.

Albumin-based cancer therapeutics for intraperitoneal drug delivery: a review

“…Nanoparticle albumin-bound paclitaxel (Nab-PTX, Abraxane V R ) was developed and demonstrated superior antitumor activity and less side-effects compared to Sb-PTX (Kinoshita et al, 2014). Likewise, methotrexate (MTX), 5-fluorouracil (5-FU), docetaxel and doxorubicin (DOX) were bound to albumin to improve the pharmacokinetics and pharmacodynamics of the drugs (Burger et al, 2001;D'Cruz et al, 2010;Maltas et al, 2016;Sharma et al, 2017). In theory, any cancer drug may be delivered IP but it is rational to explore IP delivery of albumin-bound chemotherapy.…”

Chiral ionic liquids supported on natural sporopollenin microcapsules

“…SEC have been used to sequester edible oils from emulsions efficiently, encapsulate various polar and nonpolar materials, and act as drug delivery systems with excellent enhanced bioavailability. [22][23][24][25][26][27] On the other hand, the presence of functional groups on the outer surface allows for their further modication. Chemically modied SEC have been employed in water remediation studies, 28 as stationary phases chromatography, 29 and as solid supports for peptide synthesis, 30 enzyme immobilization, 31,32 and chemical reactions.…”

A Simple and Easy Method of Monitoring Doxorubicin Release from a Liposomal Drug Formulation in the Serum Using Fluorescence Spectroscopy

“…The linear calibration curve was obtained when the amount of doxorubicin was less than 2 µg; this result is similar to that reported previously. 20) From the calibration curve, the limit of quantitation was found to be less than 0.2 µg and the relative standard deviation of 1-4 µg of doxorubicin was approximately 1.5%. Although the slope of the calibration curve was small in the high-quantity region of doxorubicin, the amount of doxorubicin (released amount) could be measured by fluorescence intensity.…”