Development of drug-in-adhesive transdermal patch forα-asarone and in vivo pharmacokinetics and efficacy evaluation

Curcumin-Eudragit® E PO solid dispersion: A simple and potent method to solve the problems of curcumin

“…Anti-inflammatory effect of several 625 matrix-type transdermal films prepared by curcumin and selected 626 polymers was investigated by in vitro and in vivo tests [20]. On the 627 other hand, Eudragit Ò E 100 was reported to be formulated as 628 transdermal drug-in-adhesive patches [57]. We assessed the feasi- …”

“…In recent decades, curcumin has been 57 extensively investigated for its wide spectrum of therapeutic 58 properties, such as antioxidant, anti-inflammatory, anti-cancer, 59 antimicrobial, wound healing, and potential prevention ability of 60 neurodegenerative diseases [2][3][4][5]. Unlike other phytochemicals 61 and most synthetic chemotherapeutic agents, curcumin can affect 62 more than one hundred molecular targets and many different 63 pathways which endows curcumin particular edge over its coun-64 terparts [6].…”

Development and Evaluation of α-Asarone Transdermal Patches Based on Hot-Melt Pressure-Sensitive Adhesives

“…The relative bioavailability of the HMPSA patch was 1,494% compared with an oral dose, while it was reported that the relative bioavailabilities of DIA patches prepared by Eudragit E PO and reservoir type patches were 426% and 951%, respectively (26). Furthermore, no skin irritation was observed after the transdermal experiments with HMPSA, demonstrating its biocompatibility.…”

Adsorption–desorption mechanism of a cationic polyelectrolyte based on dimethylaminoethyl polymethacrylates at the water/1,2-dichloroethane interface

“…It has been evaluated the performance of solid dispersions containing Eudragit and different drugs such as divalproex sodium [6], albendazole [7], piroxicam [8], lidocaine [9]. This polyelectrolyte has also been used for drug delivery systems in various transdermal systems [10].…”