Development of Effective Tumor Vaccine Strategies Based on Immune Response Cascade Reactions

Wu, Huayue; Fu, Xinghe; Zhai, Yujia; Gao, Shan; Yang, Xiaoye; Zhai, Guangxi

doi:10.1002/adhm.202100299

Cited by 33 publications

(22 citation statements)

References 134 publications

(193 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to its advantages of tumor specificity and long maintenance time in vivo, vaccine therapy has become a popular research field in cancer therapy [24,34]. The vaccine can be divided into therapeutic vaccines and preventive vaccines [36]. Therapeutic vaccines have significantly different characteristics from traditional preventive vaccines [36].…”

Section: Vaccinementioning

confidence: 99%

See 1 more Smart Citation

The application of carbon dots in tumor immunotherapy: researches and prospects

Hong

Cai

Abbas

et al. 2023

Preprint

View full text Add to dashboard Cite

Since the rapid development of nanomedicine in oncotherapy, multiple nanomaterials are adopted to regulate the immune system in cancer individuals. Tumor immunotherapy enhances the immune function of patients to achieve the purpose of killing tumor cells by utilizing the organism immune mechanism. As emerging inorganic carbon nanoparticles, carbon dots (CDs) have been found as photosensitizers, vaccines, immunoadjuvants, and so on for cancer treatment due to their unique structure and property, such as effective platforms for drug delivery, immunomodulation, and phototherapy. In this review, we mainly discuss the recent application of CDs in tumor immunotherapy and the prospects of CDs in the field of immune medicine. By assessing the achievements and challenges of CDs in tumor immunotherapy, our review would provide mechanistic insights into the evolution of future nanomedicine.

show abstract

Section: Vaccinementioning

confidence: 99%

“…The vaccine can be divided into therapeutic vaccines and preventive vaccines [36]. Therapeutic vaccines have significantly different characteristics from traditional preventive vaccines [36]. It needs to be designed and engineered to gain the ability for tumor-specific treatment [24].…”

Section: Vaccinementioning

confidence: 99%

The application of carbon dots in tumor immunotherapy: researches and prospects

Hong

Cai

Abbas

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Thus, coating inorganic nanoparticles with tumor cell membranes is widely accepted and can be applied to other tumor models. It could also be used as personalized medicine in cancer vaccination to prevent cancer recurrences, where the patient's tumor cell membrane can be the raw material 65 …”

Section: Applications Of Biological Membrane‐coated Inorganic Nanopar...mentioning

confidence: 99%

“…It could also be used as personalized medicine in cancer vaccination to prevent cancer recurrences, where the patient's tumor cell membrane can be the raw material. 65 …”

Section: Applications Of Biological Membrane‐coated Inorganic Nanopar...mentioning

confidence: 99%

Targeting inorganic nanoparticles to tumors using biological membrane‐coated technology

Zhang

Chen

Zhu

et al. 2022

MedComm

View full text Add to dashboard Cite

Inorganic nanoparticles have extensively revolutionized the effectiveness of cancer therapeutics due to their distinct physicochemical properties. However, the therapeutic efficiency of inorganic nanoparticles is greatly hampered by the complex tumor microenvironment, patient heterogeneity, and systemic nonspecific toxicity. The biomimetic technology based on biological membranes (cell-or bacteria-derived membranes) is a promising strategy to confer unique characteristics to inorganic nanoparticles, such as superior biocompatibility, prolonged circulation time, immunogenicity, homologous tumor targeting, and flexible engineering approaches on the surface, resulting in the enhanced therapeutic efficacy of inorganic nanoparticles against cancer. Therefore, a greater push toward developing biomimetic-based nanotechnology could increase the specificity and potency of inorganic nanoparticles for effective cancer treatment. In this review, we summarize the recent advances in biological membrane-coated inorganic nanoparticles in cancer precise therapy and highlight the different types of engineered approaches, applications, mechanisms, and future perspectives. The surface engineering of biological membrane can greatly enhance their targeting, intelligence, and functionality, thereby realizing stronger tumor therapy effects. Further advances in materials science, biomedicine, and oncology can facilitate the clinical translation of biological membrane-coated inorganic nanoparticles.

show abstract

“…Therapeutic tumor vaccines can activate antigen-presenting cells (APCs) and T lymphocytes upstream of the cancer-immune circulation, which can make use of a patient’s own immune system to recognize and eliminate tumor cells. , As one of the most typical strategies of tumor immunotherapy, therapeutic tumor vaccines have attracted extensive attention. , Recent works include vaccines based on tumor-associated antigens (TAAs) and vaccines prepared by patients’ own cancer cells in vitro . However, these strategies either require precise mapping of tumor tissue and proper selection of TAAs or require complex cancer cell acquisition and in vitro processing procedures, which are time-consuming and costly .…”

Section: Introductionmentioning

confidence: 99%

ER-Targeting PDT Converts Tumors into In Situ Therapeutic Tumor Vaccines

Liu

et al. 2022

ACS Nano

View full text Add to dashboard Cite

A therapeutic tumor vaccine is a promising approach to cancer treatment. One of its strategies is to treat patient-derived tumor cells in vitro and then administer them in vivo to induce an adaptive immune response and achieve cancer treatment. Here, we want to explore the possibility of converting cancer tissue into a therapeutic tumor vaccine through induced immunogenic cell death (ICD) in situ. We loaded indocyanine green (ICG) into liposomes (ICG-Lipo) and modified it with the pardaxin peptide to realize an endoplasmic reticulum (ER)-targeting function (Par-ICG-Lipo). A microfluidic technique was developed for loading ICG, a water-soluble molecule, into liposomes with a high encapsulation efficiency (greater than 90%). Under near-infrared (NIR) irradiation, ER-targeting photodynamic therapy (PDT) induced by Par-ICG-Lipo could promote the release of danger-signaling molecules (DAMPs) and tumor antigens (TAAs) in vivo, which significantly enhanced the immunogenicity in vivo and thus stimulates a strong antitumor immune response. This process would be further amplified by adopting dendritic cells. In general, our strategy transformed in situ tumor cells into therapeutic vaccines by ER-targeting PDT, which could provide a clinically applicable and effective approach for cancer treatment.

show abstract

Development of Effective Tumor Vaccine Strategies Based on Immune Response Cascade Reactions

Cited by 33 publications

References 134 publications

The application of carbon dots in tumor immunotherapy: researches and prospects

The application of carbon dots in tumor immunotherapy: researches and prospects

Targeting inorganic nanoparticles to tumors using biological membrane‐coated technology

ER-Targeting PDT Converts Tumors into In Situ Therapeutic Tumor Vaccines

Contact Info

Product

Resources

About