Development of Eye Movement Image Analysis Technique in Conscious Guinea Pigs.

Horiike, Osamu; Ikeda, Takuo; Shimogori, Hiroaki; Sugahara, Kazuma; Hashimoto, Makoto; Okuda, Takashi; Yamashita, Hiroshi

doi:10.3757/jser.61.28

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…We measured the horizontal vestibulo-ocular refl ex (VOR) using our method as previously reported [21,22] . Briefl y, in order to immobilize the guinea pig, a cage designed to hold the animal still during experiments was mounted on top of a turntable apparatus (Daiichi Medical, Tokyo, Japan).…”

Section: Evaluation Of Vestibular Functionmentioning

confidence: 99%

CGRP Expression in the Vestibular Periphery after Transient Blockage of Bilateral Vestibular Input

Hara

Takeno

Shimogori

et al. 2005

ORL

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This study aimed to establish an animal model of reversible bilateral vestibular disorders that is suitable for examining the mechanisms of vestibular plasticity, and to observe the changes in the plasticity of vestibular efferent systems. Tetrodotoxin (TTX) was infused continuously for 7 days into the bilateral perilymph of guinea pig cochlea. We assessed the vestibulo-ocular reflex (VOR) for evaluating the vestibular function. We also investigated the changes in calcitonin gene-related peptide (CGRP) immunoreactivity in vestibular end organs to observe the changes in the plasticity of vestibular systems. The VOR was completely eliminated by TTX administration and returned to the preoperative levels within 120 h after TTX discontinuation. An obvious increase in the number of CGRP-immunoreactive fibers was observed within the neurosensory epithelia of the maculae and cristae. An animal model of reversible bilateral vestibular disorders was established and used for investigating the plasticity of the vestibular nervous system.

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Section: Evaluation Of Vestibular Functionmentioning

confidence: 99%