In this paper, fatigue life prediction of U‐notched polymethyl methacrylate (PMMA) plate is numerically investigated based on the combination of fatigue damage mechanism and fatigue crack propagation mechanism. First, strength and stiffness degeneration criterions during the fatigue process are established on the basis of nonlinear progressive damage evolution, and the fatigue crack initiation life is estimated. Second, fatigue crack propagation phase is analysed through virtual crack closure technique. The fatigue crack propagation life before totally fracture is also predicted. Finally, finite element models of PMMA plate weakened by lateral symmetric U‐notch are built up using ABAQUS, and the total fatigue life of notched plate is calculated by combining the crack initiation life with the crack propagation life. These results will play an important role for evaluating the fatigue life of U‐notched PMMA plate.