2024
DOI: 10.1007/s11259-024-10420-1
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Development of fatty liver disease model using high cholesterol and low choline diet in white leghorn chickens

Kush Kumar Yadav,
Patricia A. Boley,
Saroj Khatiwada
et al.

Abstract: Nonalcoholic fatty liver disease (NAFLD), which shows similar symptoms as fatty liver hemorrhage syndrome (FLHS) in chickens, is the most common cause of chronic liver disease and cancer in humans. NAFLD patients and FLHS in chickens have demonstrated severe liver disorders when infected by emerging strains of human hepatitis E virus (HEV) and avian HEV, respectively. We sought to develop a fatty liver disease chicken model by altering the diet of 3-week-old white leghorn chickens. The high cholesterol, and lo… Show more

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