Development of Fine Poly(D,L-Lactic-Co-Glycolic Acid) Particles for Hydrophilic Drug Using a Solid-in-Oil-in-Water Emulsion

Toorisaka, Eiichi; Watanabe, Kikumi; Hirata, Makoto

doi:10.4236/jeas.2018.82004

Cited by 4 publications

(6 citation statements)

References 15 publications

(11 reference statements)

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“…PLGA nanoparticle production has been the subject of many investigations and excellent reviews [50,51]. In this study we formulated nanoparticles using water-in-oil-in-water (w/o/w) emulsion [52] and solid-in-oil-in-water (s/o/w) emulsion [53] methodologies, and their properties and tobramycin loading are reported in Table 1. Both methodologies resulted in loading of tobramycin within the nanoparticles (albeit relatively low concentrations of drug in the particles).…”

Section: Resultsmentioning

confidence: 99%

Formulation of Antimicrobial Tobramycin Loaded PLGA Nanoparticles via Complexation with AOT

Hill

Cunningham

Hathout

et al. 2019

JFB

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Tobramycin is a potent antimicrobial aminoglycoside and its effective delivery by encapsulation within nanoparticle carriers could increase its activity against infections through a combination of sustained release and enhanced uptake. Effective antimicrobial therapy against a clinically relevant model bacteria (Pseudomonas aeruginosa) requires sufficient levels of therapeutic drug to maintain a drug concentration above the microbial inhibitory concentration (MIC) of the bacteria. Previous studies have shown that loading of aminoglycoside drugs in poly(lactic-co-glycolic) acid (PLGA)-based delivery systems is generally poor due to weak interactions between the drug and the polymer. The formation of complexes of tobramycin with dioctylsulfosuccinate (AOT) allows the effective loading of the drug in PLGA-nanoparticles and such nanoparticles can effectively deliver the antimicrobial aminoglycoside with retention of tobramycin antibacterial function.

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Section: Resultsmentioning

confidence: 99%

Formulation of Antimicrobial Tobramycin Loaded PLGA Nanoparticles via Complexation with AOT

Hill

Cunningham

Hathout

et al. 2019

JFB

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“…Stability of the preparation was maintained by using 5% of lipophilic surfactant. In s-o-w emulsion, PLGA acted as a hydrophilic carrier for protein drugs and the size of oil droplets was controlled by membrane emulsification method [ 55 ].…”

Section: Types Of Emulsionsmentioning

confidence: 99%

“… In s-o-w method, a complex of drug and surfactant diffuses in oil layer and therefore the emulsion particle size can be controlled and it can help in preventing the loss of aqueous soluble substances from the emulsions [ 55 ]. It is a useful method to maintain protein integrity as solid-state proteins are stable in a hydrophobic solvent [ 29 ] “Water organic solvent interface” development is prevented in the solid-in-oil first emulsion [ 31 ].…”

Section: Advantagesmentioning

confidence: 99%

Section: Advantagesmentioning

confidence: 99%

“… Further studies need to be done to analyze the integrity of delicate materials encapsulated within the matrix of microspheres [ 121 ]. As there are limited studies related to s-o-w emulsion, detailed investigation needs to be done to determine the correct weight of therapeutic agent and volume of oil, its ratio, type of polymer/copolymer, and/or surfactant along with its concentration so as to develop a compatible formulation with optimal properties [ 32 , 38 , 44 , 50 , 55 ]. …”

Section: Challengesmentioning

confidence: 99%

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Solid-in-Oil-in-Water Emulsion: An Innovative Paradigm to Improve Drug Stability and Biological Activity

Sawant

Kamath

et al. 2021

AAPS PharmSciTech

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An emulsion is a biphasic dosage form comprising of dispersed phase containing droplets that are uniformly distributed into a surrounding liquid which forms the continuous phase. An emulsifier is added at the interface of two immiscible liquids to stabilize the thermodynamically unstable emulsion. Various types of emulsions such as water-in-oil (w-o), oil-in-water (o-w), microemulsions, and multiple emulsions are used for delivering certain drugs in the body. Water (aqueous) phase is commonly used for encapsulating proteins and several other drugs in water-in-oil-in-water (w-o-w) emulsion technique. But this method has posed certain problems such as decreased stability, burst release, and low entrapment efficiency. Thus, a novel “solid-in-oil-in-water” (s-o-w) emulsion system was developed for formulating certain drugs, probiotics, proteins, antibodies, and tannins to overcome these issues. In this method, the active ingredient is encapsulated as a solid and added to an oil phase, which formed a solid-oil dispersion. This dispersion was then mixed with water to form a continuous phase for enhancing the drug absorption. This article focuses on the various studies done to investigate the effectiveness of formulations prepared as solid-oil-water emulsions in comparison to conventional water-oil-water emulsions. A summary of the results obtained in each study is presented in this article. The s-o-w emulsion technique may become beneficial in near future as it has shown to improve the stability and efficacy of the entrapped active ingredient. Graphical abstract

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2023

WATER

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In the modern world, the focus of natural science research thought has shifted mainly to the molecular level, including the study of water. Water is considered as a mixture of interacting H 2 O molecules and their clusters based on the data of molecular dynamics, neutron, and X-ray scattering. In this case, a huge layer of information is lost related to the composition of real water, its microstructure and behavior. The aim of our study was to follow the phase transformations of hydrated liquid crystal water during the evaporation of free water using optical microscopy. We observed a panoramic picture of a cascade of interrelated phase transitions of distilled water and its microdispersed phase -sodium chloride (NaCl) microcrystals surrounded by a thick layer of hydrated liquid crystal water. Incubation of a glass slide in water for two days was accompanied by adhesion of the microdispersed phase to the glass surface. During the free evaporation of distilled water from a Petri dish, erosion of hydration shells, dissolution of NaCl microcrystals, and further recrystallization with the formation of large monolithic crystals and traces of non-drying water were observed. However, there are still questions that do not yet have clear answers. This work is intended to supplement our knowledge in the field of phase transitions of water during its evaporation from hydrophilic surfaces, which can be of not only theoretical, but also practical importance in, for example, the operation of water supply networks and water purification systems.

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Development of Fine Poly(D,L-Lactic-Co-Glycolic Acid) Particles for Hydrophilic Drug Using a Solid-in-Oil-in-Water Emulsion

Cited by 4 publications

References 15 publications

Formulation of Antimicrobial Tobramycin Loaded PLGA Nanoparticles via Complexation with AOT

Formulation of Antimicrobial Tobramycin Loaded PLGA Nanoparticles via Complexation with AOT

Solid-in-Oil-in-Water Emulsion: An Innovative Paradigm to Improve Drug Stability and Biological Activity

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