Development of food grade 3D printable ink based on pectin containing cannabidiol/cyclodextrin inclusion complexes

Andriotis, Eleftherios G.; Monou, Paraskevi Kyriaki; Louka, A.; Papaefstathiou, E.; Eleftheriadis, Georgios K.; Fatouros, Dimitrios G.

doi:10.1080/03639045.2020.1791168

Cited by 26 publications

(18 citation statements)

References 61 publications

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“…12 , Fig. 13 ) presented an endothermic peak that indicates the melting point of 68.97 °C confirming the results of Andriotis and his co-authors (69 °C) ( Andriotis et al, 2020 ). The T onset was 66.45 °C, the T endset was 71.43 °C while the ΔH = 20.12 J/g.…”

Section: Compatibility Studiessupporting

confidence: 84%

“…9 ) can be highlighted in comparison with the excipients by the presence of the bands belonging to C = C and =C–H aliphatic groups (1582 and 1627 cm −1 ) ( Table 10 ). These two specific bands were observed also in the studies conducted by Andriotis et al ( Andriotis et al, 2020 ) In most of the cases the previously mentioned bands could be observed in the binary mixtures, the only exceptions being represented by CBD:PODTG2 ( Fig. 7 ) where a prominent band was observed at 1642 cm −1 .…”

Section: Compatibility Studiessupporting

confidence: 74%

“…PETsp is a co-processed ready to use white excipient. This excipient presents advantages such as good API stability, good flowability, good mechanical properties, and low friability ( Vlad et al, 2020 , Andriotis et al, 2020 ).…”

Section: Resultsmentioning

confidence: 99%

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Pharmacotechnical and analytical preformulation studies for cannabidiol orodispersible tablets

Vlad

Antonoaea

Todoran

et al. 2021

Saudi Pharmaceutical Journal

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Obtaining orodispersible tablets (ODT) containing substances from the second Biopharmaceutical Class has raised concerns as the dissolution test is challenging. This study aimed to select suitable excipients for developing orodispersible tablets containing cannabidiol (CBD) by direct compression method. No similar studies were found in the literature. Excipients from different classes were characterized using the SeDeM-ODT tool: fillers – lactose (LCT) and microcrystalline cellulose (CelMC), sweeteners – sorbitol (SRB) and mannitol (MNT), disintegrants – sodium starch glycolate (SSG), sodium croscarmellose (CCS), soy polysaccharides (Emcosoy® – EMCS) and two co-processed excipients (Prosolv®-ODT G2 – PODTG2 and Prosolv® EasyTab sp – PETsp). Drug compatibility with excipients in binary mixtures (1:1) was verified by Differential Scanning Calorimetry (DSC) and Fourier Transform-Infrared (FTIR) spectroscopy. Using the SeDeM-ODT expert system, the fillers and the co-processed excipients showed good properties regarding compressibility and disintegration behavior. Also, the DSC and FTIR results showed that small or no interactions between the CBD and the excipients took place.

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Section: Compatibility Studiessupporting

confidence: 84%

Section: Compatibility Studiessupporting

confidence: 74%

See 1 more Smart Citation

Pharmacotechnical and analytical preformulation studies for cannabidiol orodispersible tablets

Vlad

Antonoaea

Todoran

et al. 2021

Saudi Pharmaceutical Journal

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show abstract

“…The system consisted of a pump (LC-10 AD VP), an autosampler (SIL-20A HT), and an ultraviolet-visible detector (SPD-10A VP, Shimadzu, Kyoto, Japan). The chromatographic conditions were adapted from the literature, with modifications (30,39). The stationary phase for CBD was a Discovery HS C18 (15 cm x 4.6 mm, 3 µm) column and the mobile phase consisted of a mixture of (A) acetonitrile and (B) phosphate buffer (KH 2 PO 4 , 0.0126M, pH 5.0), A:B 80:20.…”

Section: High-performance Liquid Chromatography (Hplc)mentioning

confidence: 99%

“…Nevertheless, the oral route is the most common due to ease of administration. To this context, a wide range of formulations aimed for oral delivery has been reported including lipid-based delivery systems (SNEDDS), gastro retentive dosage forms, amorphous solid dispersions, and cyclodextrin inclusion complexes (27)(28)(29)(30)(31), focusing mainly to cannabinoids solubility enhancement effect.…”

Section: Introductionmentioning

confidence: 99%

Development of Water-Soluble Electrospun Fibers for the Oral Delivery of Cannabinoids

et al. 2021

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Cannabidiol and cannabigerol are two active pharmaceutical ingredients, derived from cannabis plant. In the present study, CBD and CBG were co-formulated with polyvinyl(pyrrolidone) (PVP) and Eudragit L-100, using electrohydrodynamic atomization (electrospinning). The produced fibers were smooth and uniform in shape, with average fiber diameters in the range of 700 -900 nm for PVP fibers and 1-5 µm for Eudragit L-100 fibers. Drug loading and encapsulation efficiency were calculated for all formulations, with high encapsulation efficiencies (over 90%). Both in vitro release and in vitro disintegration tests of the formulations in SCF and SGF indicated the rapid dissolution of the fibers and the subsequent rapid release of the drugs. The study concluded that the electrospinning process is a fast and efficient method to produce drug-loaded fibers with enhanced properties, suitable for the per os administration of cannabinoids.

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Development and Characterization of New Cannabidiol‐Loaded Polycaprolactone Nanoparticles for Increased Bioavailability

Ediz,

Demirel Kars,

Çetin

2024

ChemistrySelect

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The potential therapeutic applications of herbal cannabidiol (CBD) extend to various health conditions such as multiple sclerosis, cancer, insomnia, and anxiety. However, the practical use of CBD for medicinal purposes is hindered by its high lipophilicity, bioavailability and dosing. To overcome this, CBD was encapsulated in the biodegradable and biocompatible polymer polycaprolactone (PCL) ensuring prolonged release. Ultrasonication and oil‐in‐water emulsion were employed to fabricate PCL nanoparticles (NPs), and at optimal conditions, different amounts of CBD were encapsulated within PCL NPs. Morphological and physicochemical characteristics of the nanoparticles were evaluated via FE‐SEM, STEM, zeta sizer, HPLC, FT‐IR and DSC analyses. The blank and CBD‐loaded NPs exhibited mean particle diameters in between 207.5 nm and 227.7 nm with charges ranging −23.37 and −9.40 mV. The stabilities of the NPs were evaluated for 4‐day period and NPs are found to be stable in terms of size and zeta potential. Release kinetics of CBD‐loaded NPs were found to fit Zero‐order kinetic model at pH 1.2 and Higuchi kinetic model at pH 7.4. The internalization of NPs into fibroblast cells was depicted using fluorescence microscopy. The effect of CBD and NPs‐4 on the proliferation of the fibroblast and breast cancer cells were demonstrated. The results clearly indicate that the NP formulation reduced the toxic effects of CBD on both cell types. The findings suggest the potential application of innovative NPs as carriers for sustained release of CBD to be used in new formulations.

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Development of food grade 3D printable ink based on pectin containing cannabidiol/cyclodextrin inclusion complexes

Cited by 26 publications

References 61 publications

Pharmacotechnical and analytical preformulation studies for cannabidiol orodispersible tablets

Pharmacotechnical and analytical preformulation studies for cannabidiol orodispersible tablets

Development of Water-Soluble Electrospun Fibers for the Oral Delivery of Cannabinoids

Development and Characterization of New Cannabidiol‐Loaded Polycaprolactone Nanoparticles for Increased Bioavailability

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