Development of Function in the Metanephric Kidney

Satlin, Lisa M.; Woda, Craig B.; Schwartz, George J.

doi:10.1016/b978-012722441-1/50020-8

Cited by 14 publications

(10 citation statements)

References 501 publications

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“…These results were anticipated because the neonatal kidneys have undergone a dramatic hemodynamic change after birth whereby the renal system switches from a fetal to a neonatal organ with high blood flow and low vascular resistance. 18,19 Whether the glomerular enlargement observed in the preterm kidneys is indicative of glomerular hyperfiltration, however, cannot be determined in the current study. As the full complement of nephrons is not achieved until late in gestation, it is conceivable that the preterm kidney may not be able to cope with the postnatal functional demands, resulting in compensatory glomerular hypertrophy.…”

Section: Discussioncontrasting

confidence: 42%

Accelerated Maturation and Abnormal Morphology in the Preterm Neonatal Kidney

Sutherland

Gubhaju²,

Moore

et al. 2011

Journal of the American Society of Nephrology

292

253

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Nephrogenesis is ongoing at the time of birth for the majority of preterm infants, but whether postnatal renal development follows a similar trajectory to normal in utero growth is unknown. Here, we examined tissue collected at autopsy from 28 kidneys from preterm neonates, whose postnatal survival ranged from 2 to 68 days, including 6 that had restricted intrauterine growth. In addition, we examined kidneys from 32 still-born gestational controls. We assessed the width of the nephrogenic zone, number of glomerular generations, cross-sectional area of the renal corpuscle, and glomerular maturity and morphology. Renal maturation accelerated after preterm birth, with an increased number of glomerular generations and a decreased width of the nephrogenic zone in the kidneys of preterm neonates. Of particular concern, compared with gestational controls, preterm kidneys had a greater percentage of morphologically abnormal glomeruli and a significantly larger cross-sectional area of the renal corpuscle, suggestive of renal hyperfiltration. These observations suggest that the preterm kidney may have fewer functional nephrons, thereby increasing vulnerability to impaired renal function in both the early postnatal period and later in life.

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Section: Discussioncontrasting

confidence: 42%

Accelerated Maturation and Abnormal Morphology in the Preterm Neonatal Kidney

Sutherland

Gubhaju²,

Moore

et al. 2011

Journal of the American Society of Nephrology

292

253

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“…In support of this idea, at postnatal day 28 C Cr remained significantly lower among preterm neonates compared with term infants whereas there was no significant difference in FE Na . Overall, these results suggest that renal functional capacity increases with renal structural maturity, potentially through increased filtration surface area (increased number of nephrons in those neonates with ongoing postnatal nephrogenesis (48) and/or increased capillary growth) (31,48), the maturation of tubular cells (40), as well as the substantial changes in renal blood flow and renal vascular resistance that occur after birth (54).…”

Section: Maturation Of Renal Function In the Early Postnatal Periodmentioning

confidence: 99%

Assessment of renal functional maturation and injury in preterm neonates during the first month of life

Gubhaju

Sutherland

Horne

et al. 2014

American Journal of Physiology-Renal Physiology

108

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“…In preterm neonates glomerular filtration rate (GFR) is very low at birth, and does not rise as rapidly as full term infants during the neonatal period [20,21]. As expected, glomerular filtration rate has shown to increase more rapidly after 34 weeks gestation [22,23] which coincides with the timing of the completion of nephrogenesis. Numerous studies have shown that preterm birth can lead to a high incidence of renal dysfunction in the neonate and under severe circumstances this can lead to renal failure [24,25].…”

Section: Renal Functionmentioning

confidence: 84%

Preterm Birth and/or Factors that Lead to Preterm Delivery: Effects on the Neonatal Kidney

Ryan¹,

Black²

2015

J Neonatal Biol

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Preterm birth (defined as birth prior to 37 completed weeks of gestation), occurs in approximately 10% of all births and is one of the leading causes of neonatal morbidity and mortality worldwide. Preterm infants are born at a time when kidney development is still ongoing, and consequently can lead to renal impairment (in both the short-term and long-term), as well as severe glomerular abnormalities in some preterm infants. Since the glomerular abnormalities are not present in all preterm kidneys, this suggests that it is not preterm birth per se that leads to the glomerular abnormalities but may relate to factors associated with the etiology of the premature delivery, or factors in neonatal care. In this review, we provide an overview of what is currently known of how prenatal and postnatal factors can potentially impact on the immature kidneys of infants born preterm.

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Development of Function in the Metanephric Kidney

Cited by 14 publications

References 501 publications

Accelerated Maturation and Abnormal Morphology in the Preterm Neonatal Kidney

Accelerated Maturation and Abnormal Morphology in the Preterm Neonatal Kidney

Assessment of renal functional maturation and injury in preterm neonates during the first month of life

Preterm Birth and/or Factors that Lead to Preterm Delivery: Effects on the Neonatal Kidney

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