Development of Fused and Substituted Pyrimidine Derivatives as Potent Anticancer Agents (A Review)

Functionalized hybrid magnetic catalytic systems on micro- and nanoscale utilized in organic synthesis and degradation of dyes

“…194 Besides, benzo [4,5]imidazo [1,2-a]pyrimidines are biologically related fused pyrimidine derivatives, which demonstrate highlighted therapeutic and biological characteristics such as antimicrobial, 195 anti-inammatory, 196 protein kinase inhibitor, 197 and anticancer. 198 In this report, a hybrid magnetic nanocomposite, ZnS/ CuFe 2 O 4 , was applied as a heterogeneous catalyst to synthesize 2,4,5-triaryl-1H-imidazole derivatives through the one-pot condensation of various aromatic aldehydes, benzyl and ammonium acetate, as depicted in Fig. 33.…”

“… 194 Besides, benzo[4,5]imidazo[1,2- a ]pyrimidines are biologically related fused pyrimidine derivatives, which demonstrate highlighted therapeutic and biological characteristics such as antimicrobial, 195 anti-inflammatory, 196 protein kinase inhibitor, 197 and anticancer. 198 …”

Synthetic Approaches for Pharmacologically Active Decorated Six-Membered Diazines

“…This "privileged scaffold" and "derivatives" either as substituted or as fused systems gain wide interest due to plentiful biological activities reported over the years. Those versatile biological activities include (and not limited to) modulation of myeloid leukemia (for example imatinib, Dasatinib and nilotinib are pyrimidine-based drugs and well established treatments for leukemia) [1,2], breast cancer and idiopathic pulmonary fibrosis [3], antimicrobial [4], antifungal [5], antiparasitic [6], diuretic [7], antitumor [8][9][10][11][12][13], antifilarial [14], DNA topoisomerase II inhibitors [15], antitubercular agents [16], antimalarial [17] and antiplasmodial [18], anti-inflammatory and analgesic activities [19][20][21], anti-HIV [5,22,23], cardiovascular agents and antihypertensive [24,25], antiulcer agents [18], hair disorders activities [26], calcium-sensing receptor antagonists, DPP-IV inhibitors [27,28], antidiabetic [29], potent adenosine A2a receptor agonistic or antagonist action [30], TLR8 or [15] or interferon beta (IFN-β) modulators [31], vascular relaxation for ocular ciliary artery and neuroprotection on retinal ganglion cell [32], 3hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors and coronary heart disease therapeutics [33], anticancer [8,[34]…”

Design, Synthesis, and Bioactivities of Novel Trifluoromethyl Pyrimidine Derivatives Bearing an Amide Moiety

“…Due to their unique biological structure, nitrogencontaining heterocyclic compounds have the characteristics of high target specificity and good environmental compatibility, which have become a research hotspot in the creation of new pesticides (Mermer et al, 2021). Among them, pyrimidine is an important lead molecule and an active fragment in the design of biologically active molecules, which is widely used in the design of pesticides and pharmaceutical molecules (Abbas et al, 2021), plant growth regulation (Tsygankova et al, 2018), and other biological activities. Many pyrimidine pesticide molecules are on the market, such as azoxystrobin, fluoxastrobin, pyrimethamine sulfonate, pyrimfen, cyclopropenyl, sulfluramid, and sulfonylureas.…”