Development of Ga-68 radiolabeled DOTA functionalized and acetylated PAMAM dendrimer-coated iron oxide nanoparticles as PET/MR dual-modal imaging agent

Almasi, Tinoosh; Gholipour, Nazila; Akhlaghi, Mehdi; Kheirabadi, Amin Mokhtari; Mazidi, Seyed Mohammad; Hosseini, Seyed Hasan; Geramifar, Parham; Beiki, Davood; Rostampour, Nima; Shahbazi‐Gahrouei, Daryoush

doi:10.1080/00914037.2020.1785451

Cited by 12 publications

(14 citation statements)

References 65 publications

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“…Another report performed biodistribution studies of novel dendrimer complex in fibrosarcoma murine model [ 60 ]. They developed a generation 4 PAMAM dendrimer-coated MIONPs (IO@G4PM) modified with p-SCN-Bz-DOTA with the acetylation-free amine groups and radiolabeled with Gallium-68.…”

Section: Discussionmentioning

confidence: 99%

Radiolabeled Dendrimer Coated Nanoparticles for Radionuclide Imaging and Therapy: A Systematic Review

et al. 2023

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Background: Dendrimers are nanoscale-size polymers with a globular structure. They are composed of an internal core and branching dendrons with surface active groups which can be functionalized for medical applications. Different complexes have been developed for imaging and therapeutic purposes. This systematic review aims to summarize the development of newer dendrimers for oncological applications in nuclear medicine. Methods: An online literature search was conducted on Pubmed, Scopus, Medline, Cochrane Library, and Web Of Science databases selecting published studies from January 1999 to December 2022. The accepted studies considered the synthesis of dendrimer complexes for oncological nuclear medicine imaging and therapy. Results: 111 articles were identified; 69 articles were excluded because they did not satisfy the selection criteria. Thus, nine duplicate records were removed. The remaining 33 articles were included and selected for quality assessment. Conclusion: Nanomedicine has led researchers to create novel nanocarriers with high affinity for the target. Dendrimers represent feasible imaging probes and therapeutic agents since, through the functionalization of external chemical groups and thanks to the possibility to carry pharmaceuticals, it can be possible to exploit different therapeutic strategies and develop a useful weapon for oncological treatments.

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Section: Discussionmentioning

confidence: 99%

Radiolabeled Dendrimer Coated Nanoparticles for Radionuclide Imaging and Therapy: A Systematic Review

et al. 2023

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“…The obtained particle size of zero generation dendrimer was found to be 827 nm. [70] The morphology for Fe 3 O 4 @ SiO 2 -G2-S shown the lattice friction values of 0.171, 0.295, 0.298 and 0.482 nm for the planes (0 2 2), (2 2 0), (4 2 2) and (1 1 1). The SAED pattern has exhibited the planes as (5 1 1), (4 0 0), (2 2 0), (4 2 2), (4 4 0) and (3 1 1).…”

Section: Characteristic Properties Of Polyamidoamine Dendrimermentioning

confidence: 94%

Effective Role of Polyamidoamine (PAMAM) Dendrimer Functionalized Nanomaterials in Anticancer Applications

et al. 2023

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One of the most severe health diseases affect the mankind is cancer. The treatment methods such as magnetic hyperthermia, chemotherapy, photothermal therapy and MRI‐traced cancer drug delivery system have been available for cancer treatment. The prime of cancer treatment is Chemotherapy but it has not proved the proper satisfaction due to the resistance developed in the tumour. Now‐a‐days, dendrimers are the most important and powerful drug carriers in the anticancer applications. The polyamidoamine (PAMAM) dendrimers have played wider role and the addition of nanomaterials in polyamidoamine dendrimer provided great results in the anticancer properties and medicinal applications. In recent years, researchers have interested to undergo investigation on dendrimer supported nanomaterials due to the outstanding experimental results against the cancer cells. Therefore, the main goal of the article is to deliberate the comprehensive overview of the properties, anticancer applications of the nanomaterials supported dendrimer as the nanocarrier for the anticancer applications.

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“…Almasi et al [ 61 ] have developed and evaluated a DMCA based on ΙOΝs for PET and MR imaging of tumors. The synthesis of the DMCA has been performed by coating ΙOΝs with the dendrimer PAMAM, a three-dimensional and hyperbranched polymer that provides functional groups in its terminals for further functionalization.…”

Section: Passive Pet/mri Dmcamentioning

confidence: 99%

Radiolabeled Iron Oxide Nanoparticles as Dual Modality Contrast Agents in SPECT/MRI and PET/MRI

et al. 2023

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During the last decades, the utilization of imaging modalities such as single photon emission computed tomography (SPECT), positron emission tomography (PET), and magnetic resonance imaging (MRI) in every day clinical practice has enabled clinicians to diagnose diseases accurately at early stages. Radiolabeled iron oxide nanoparticles (RIONs) combine their intrinsic magnetic behavior with the extrinsic character of the radionuclide additive, so that they constitute a platform of multifaceted physical properties. Thus, at a practical level, RIONs serve as the physical parent of the so-called dual-modality contrast agents (DMCAs) utilized in SPECT/MRI and PET/MRI applications due to their ability to combine, at real time, the high sensitivity of SPECT or PET together with the high spatial resolution of MRI. This review focuses on the synthesis and in vivo investigation of both biodistribution and imaging efficacy of RIONs as potential SPECT/MRI or PET/MRI DMCAs.

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Development of Ga-68 radiolabeled DOTA functionalized and acetylated PAMAM dendrimer-coated iron oxide nanoparticles as PET/MR dual-modal imaging agent

Cited by 12 publications

References 65 publications

Radiolabeled Dendrimer Coated Nanoparticles for Radionuclide Imaging and Therapy: A Systematic Review

Radiolabeled Dendrimer Coated Nanoparticles for Radionuclide Imaging and Therapy: A Systematic Review

Effective Role of Polyamidoamine (PAMAM) Dendrimer Functionalized Nanomaterials in Anticancer Applications

Radiolabeled Iron Oxide Nanoparticles as Dual Modality Contrast Agents in SPECT/MRI and PET/MRI

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