Development of Gastric Secretory Function

Dickinson, Chris J.

doi:10.1016/b978-1-4160-3479-7.10111-9

Cited by 2 publications

(2 citation statements)

References 88 publications

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“…As in adults, GL in children assumes importance in the initial digestion of short and medium chain fatty acids. It is more effective at alkaline pH and aids in digestion by emulsification process [57,58]. The assimilation of drugs given in drops containing oily vehicles may therefore be affected by the age of the child due to changing pH, which in turn may result in variation in enzyme efficiency.…”

Section: Discussionmentioning

confidence: 99%

Risk assessment for extending the Biopharmaceutics Classification System-based biowaiver of immediate release dosage forms of fluconazole in adults to the paediatric population

Charoo¹,

Cristofoletti

Dressman

2015

Journal of Pharmacy and Pharmacology

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Thus, it can be safely concluded that fluconazole meets highly soluble and highly permeable criteria in the paediatric population and can be allocated to class 1 of the Biopharmaceutics Classification System (BCS) for this population as well as in adults. Additionally, fluconazole has an excellent safety profile in children, similar to that in adults. The BCS-based biowaiver claimed in adults can be safely extended to the paediatric population provided that the requirements in excipient selection and dissolution profile comparison using BCS-based dissolution conditions as stated in the biowaiver monograph for fluconazole immediate release dosage forms in adults are fulfilled.

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Section: Discussionmentioning

confidence: 99%

Risk assessment for extending the Biopharmaceutics Classification System-based biowaiver of immediate release dosage forms of fluconazole in adults to the paediatric population

Charoo¹,

Cristofoletti

Dressman

2015

Journal of Pharmacy and Pharmacology

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“…The stomach is a secretory organ that produces basal as well as nutrient-induced secretions. 10 In preterm infants, researchers have demonstrated that basal gastric secretions average 2.8 mL over a 4-hour period. 11 The volume of an obtained gastric residual is the end result of the ongoing balance between an enteral feeding and endogenous input from saliva and gastric juice and gastric emptying.…”

Section: Physiologic Considerationsmentioning

confidence: 99%

Dilemmas Surrounding Interpretation of Gastric Residuals in the NICU Setting

Kaminski

Clancy

Steward

2014

ICAN: Infant, Child, & Adolescent Nutrition

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Providing enteral nutrition to preterm infants is a challenge because of the immaturity of the gastrointestinal tract. Clinicians often take a cautious approach to advancing enteral feedings because of concerns related to development of feeding intolerance or necrotizing enterocolitis. Gastric residuals provide a mechanism for monitoring feeding tolerance since they are easy to obtain and quantify. Despite the common practice of monitoring gastric residuals, there is a lack of agreement in determining when an obtained gastric residual becomes clinically significant. Furthermore, numerous factors can affect the characteristics of the gastric residual. A review of the literature demonstrates significant variability in defining a clinically significant gastric residual. Importantly, there is a lack of available evidence to support selected parameters. Recommendations for practice are discussed.

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Development of Gastric Secretory Function

Cited by 2 publications

References 88 publications

Risk assessment for extending the Biopharmaceutics Classification System-based biowaiver of immediate release dosage forms of fluconazole in adults to the paediatric population

Risk assessment for extending the Biopharmaceutics Classification System-based biowaiver of immediate release dosage forms of fluconazole in adults to the paediatric population

Dilemmas Surrounding Interpretation of Gastric Residuals in the NICU Setting

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