Development of gastro-resistant tablets for the protection and intestinal delivery of Lactobacillus fermentum CECT 5716

Villena, María J. Martín; Lara-Villoslada, Ferderico; Martínez, María Adolfina Ruíz; Hernández, María Encarnación Morales

doi:10.1016/j.ijpharm.2015.03.078

Cited by 37 publications

(19 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To overcome the inability of some probiotics to survive, microencapsulated or coated probiotic strains have been developed ( 70 – 72 ). Recently, Villena and coworkers designed gastro-resistant tablets containing Lactobacillus fermentum CECT5716 using sodium alginate ( 73 ). Calcium alginate beads have also been proposed to protect the delivery of viable probiotic strains in the gastrointestinal tract ( 74 , 75 ) and have even been used to treat cold restraint-induced gastric ulcers ( 46 ).…”

Section: Probioticsmentioning

confidence: 99%

Potential role of probiotics in the management of gastric ulcer

Khoder

Al-Menhali

Al-Yassir

et al. 2016

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Gastric ulcer is one of the most common chronic gastrointestinal diseases characterized by a significant defect in the mucosal barrier. Helicobacter pylori (H. pylori) infection and the frequent long-term use of non-steroidal anti-inflammatory drugs are major factors involved in gastric ulcer development. Acid inhibitors and antibiotics are commonly used to treat gastric ulcer. However, in the last few decades, the accumulating evidence for resistance to antibiotics and the side effects of antibiotics and acid inhibitors have drawn attention to the possible use of probiotics in the prevention and treatment of gastric ulcer. Probiotics are live microorganisms that when administered in adequate amounts confer health benefits on the host. Currently, the available experimental and clinical studies indicate that probiotics are promising for future applications in the management of gastric ulcers. This review aims to provide an overview of the general health benefits of probiotics on various systemic and gastrointestinal disorders with a special focus on gastric ulcer and the involved cellular and molecular mechanisms: i) Protection of gastric mucosal barrier; ii) upregulation of prostaglandins, mucus, growth factors and anti-inflammatory cytokines; iii) increased cell proliferation to apoptosis ratio; and iv) induction of angiogenesis. Finally, some of the available data on the possible use of probiotics in H. pylori eradication are discussed.

show abstract

Section: Probioticsmentioning

confidence: 99%

Potential role of probiotics in the management of gastric ulcer

Khoder

Al-Menhali

Al-Yassir

et al. 2016

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

show abstract

“…Microencapsulation generally leads to increased survival of LAB and Bifidobacterium spp. under artificial GIT conditions, as compared to free cells [13,37,38]. Reduced survival of cells in SGJ without pepsin and pancreatin may be due to the lower pH (1.5) of SGJ without pepsin in comparison with that of SGJ with pepsin (pH 2.5).…”

Section: Discussionmentioning

confidence: 98%

Phytase-Producing Potential and Other Functional Attributes of Lactic Acid Bacteria Isolates for Prospective Probiotic Applications

Andrabi

Bhat

Gupta

et al. 2016

Probiotics & Antimicro. Prot.

View full text Add to dashboard Cite

Wide variations among multifaceted-health benefitting attributes of probiotics fueled investigations on targeting efficacious probiotics. In the current study, lactic acid bacteria (LAB) isolated from poultry gut, feces of rat, chicken, human infants, and fermented foods were characterized for desired probiotic functional properties including the phytase-producing ability which is one of the wanted characteristics for probiotics for potential applications for upgrading animal nutrition, enhancing feed conversion, and minimizing anti-nutritional properties. Among 62 LAB isolates Weissella kimchii R-3 an isolate from poultry gut exhibited substantial phytase-producing ability (1.77 U/ml) in addition to other functional probiotic characteristics viz. hydrophobicity, autoaggregation, coaggregation with bacterial pathogens, and antimicrobial activity against pathogens. Survival of W. kimchii R-3 cells (in free and calcium alginate encapsulated state) was examined sequentially in simulated gastric and intestinal juices. Encapsulated cells exhibited better survival under simulated gut conditions indicating that encapsulation conferred considerable protection against adverse gut conditions. Furthermore, simulated gastric and intestinal juices with pepsin and pancreatin showed higher survival of cells than the juices without pepsin and pancreatin. W. kimchii R-3 due to its significant functional probiotic attributes may have prospective for commercial applications in human/animal nutrition.

show abstract

“…As we have seen in Table 5, Eudragit L-100 has a great influence in probiotic protection, so Formulations 10 and 14 have the best acid resistance. However, Formulation 10 was refused because of its higher amount of sodium alginate since in a previous work we notify that pH of the medium may influence negatively the rheology of alginate gel [64], we can see this damage in Fig. 1.…”

Section: Stability Of Probiotic Tabletmentioning

confidence: 90%

“…In a previous reported work, we had a decrease in viability after 180 days [64], so the aim in this study was to enhance and improve the stability of our tablets. As we can see in Table 6, the viability inside our tablets did not change throughout the study (10 9 UFC/tablet) at the different temperatures.…”

Section: Stability Of Probiotic Tabletmentioning

confidence: 99%

Evaluation of Tablets Containing a Probiotic Strain for an Oral Administration

Sánchez¹,

AdolfinaRuiz²,

Morales³

2017

JPP

View full text Add to dashboard Cite

The scientific concept of probiotics has been widely accepted throughout the last decades; consequently, its industrial production and commercialization have been increased. This is only the beginning since a recent global probiotic market analysis estimated an annual growth, boosted mainly by a rising request from the Asian and European consumer in the next 5 years. So the pharmaceutical industry needs to develop new dosage forms containing probiotic microorganisms in order to offer consumers a variety of products. Different kinds of matrix tablets with Lactobacillus coryniformis CECT 5711 were designed to protect this strain from the technological process and harsh gastrointestinal conditions up until their arrival in the gut, as well as environmental conditions during their storage. With this aim, various retarding polymers were combined so as to get controlled release tablets. All formulations were evaluated in terms of technological processability, bacterial viability and stability. Finally, an optimal formulation with Methocel ® K-15 M EP, Eudragit L-100 and alginate sodium, which contain Lactobacillus coryniformis CECT 5711, was selected due to the fact that it assured an excellent survival of the microorganisms after their exposition to all conditions mentioned above, besides it will be able to improve human's health.promoting health in a natural way has intensified research in this area. Today, the practical use of food and supplements, including probiotics, is driven by "soft" health effects and promotion of well-being rather than the treatment of disease symptoms [3]. Nevertheless, there is enough evidence about the success of probiotics in different diseases like infant diarrhea [4,5], antibiotic-associated-diarrhea [6], traveler's diarrhea [7], ulcerative colitis [8-10] and Crohn disease [11], lactose intolerance [12], Helicobacter pylori eradication [13-15], pulmonary infections [16], low cholesterol level [17-19], antiobesity [20] and diabetes [21], allergy [22, 23], atopic eczema and skin diseases [24], cancer [25, 26] and urogenital infection [27]. Clinical trials have used various formulations and strains and the overall conclusion is that strain specificity and disease setting is important, whilst dosage and route, duration and frequency of administration must also be considered carefully [28]. Lactobacillus coryniformis CECT 5711 was isolated

show abstract

Development of gastro-resistant tablets for the protection and intestinal delivery of Lactobacillus fermentum CECT 5716

Cited by 37 publications

References 14 publications

Potential role of probiotics in the management of gastric ulcer

Potential role of probiotics in the management of gastric ulcer

Phytase-Producing Potential and Other Functional Attributes of Lactic Acid Bacteria Isolates for Prospective Probiotic Applications

Evaluation of Tablets Containing a Probiotic Strain for an Oral Administration

Contact Info

Product

Resources

About