Development of gatifloxacin-loaded cationic polymeric nanoparticles for ocular drug delivery

Duxfield, Linda; Sultana, Rubab; Wang, Ruokai; Englebretsen, Vanessa; Deo, Samantha; Swift, Simon; Rupenthal, Ilva D.; Al‐Kassas, Raida

doi:10.3109/10837450.2015.1091839

Cited by 51 publications

(29 citation statements)

References 39 publications

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“…Type of the particles (metallic substances or not), nanoparticle characteristics (morphology, size and surface) or route of administration are parameters that can induce some toxicity. Due to their small sizes, when used in intraocular way, nanoparticles could pass across ophthalmic barriers such as the trabecular meshwork leading to a systemic drug diffusion [ 81 ]. Used for topical application, nanoparticles usually do not cross corneal epithelium; Mun et al have showed that even nanoparticles small as 21 nm do not cross neither intact cornea nor denaturated cornea [ 82 ].…”

Section: Ophthalmic Formsmentioning

confidence: 99%

Ophthalmic Drug Delivery Systems for Antibiotherapy—A Review

et al. 2018

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The last fifty years, ophthalmic drug delivery research has made much progress, challenging scientists about the advantages and limitations of this drug delivery approach. Topical eye drops are the most commonly used formulation in ocular drug delivery. Despite the good tolerance for patients, this topical administration is only focus on the anterior ocular diseases and had a high precorneal loss of drugs due to the tears production and ocular barriers. Antibiotics are popularly used in solution or in ointment for the ophthalmic route. However, their local bioavailability needs to be improved in order to decrease the frequency of administrations and the side effects and to increase their therapeutic efficiency. For this purpose, sustained release forms for ophthalmic delivery of antibiotics were developed. This review briefly describes the ocular administration with the ocular barriers and the currently topical forms. It focuses on experimental results to bypass the limitations of ocular antibiotic delivery with new ocular technology as colloidal and in situ gelling systems or with the improvement of existing forms as implants and contact lenses. Nanotechnology is presently a promising drug delivery way to provide protection of antibiotics and improve pathway through ocular barriers and deliver drugs to specific target sites.

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Section: Ophthalmic Formsmentioning

confidence: 99%

Ophthalmic Drug Delivery Systems for Antibiotherapy—A Review

et al. 2018

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“…This may be attributed to nonionic nature of surfactant. Its adsorption on the surface of PLGA-NPs could reduce their surface charge (21). Table 3 shows that the EE of PLGA-NPs changed between 61.64 to 96.12 %.…”

Section: Discussionmentioning

confidence: 99%

Development of dry powder inhaler containing tadalafil-loaded PLGA nanoparticles

et al. 2017

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Inhalable dry powders containing poly lactic-co-glycolic acid (PLGA) nanoparticles (NPs) were developed for the delivery of tadalafil (TAD) for treatment of life-treating pulmonary arterial hypertension. Taguchi design was employed to evaluate the effects of different formulation variables on the physicochemical characteristics of PLGA-NPs prepared using emulsion solvent evaporation method. Inhalable PLGA-NPs of TAD were successfully prepared by co-spray drying the PLGA-NPs with inert carriers. Physicochemical characteristics and in vitro deposition of the aerosolized drug were also evaluated. The optimized formulation was prepared using 7.5 mg of PLGA, 2.5 mg of TAD, sonication time of 6 min and 2% polyvinyl alcohol (PVA) as the stabilizer. The optimized aqueous/oil phase ratio for PLGA-NPs preparation was 10:1. Polymer/drug ratio was the most effective parameter on the release efficiency. Encapsulation efficiency, zeta potential and particle size of PLGA-NPs were more affected by aqueous/organic phase ratio. The spray dried powders containing PLGA-NPs had a mass median aerodynamic diameter (MMAD) in the range of 1.4–2.8 μm that was suitable for TAD delivery to the deep region of lung. The presence of L- leucine in mannitol containing formulations decreased the interparticulate forces between particles and increased significantly the process yield and fine particle fraction (FPF). The results indicated that prepared dry powders containing TAD-loaded PLGA-NPs were suitable for inhalation and has the potential for the treatment of pulmonary arterial hypertension.

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“…21 In the current research, we aimed to investigate the biodistribution of GNPs capped with Tween ® 20 in vivo, as Tween ® 20 is one of the most efficient coating systems of colloidal Au which is a precursor for conjugation with various drugs used in the clinic. 22,23 Moreover, Tween ® 20 is uptaken preferentially by the reticuloendothelial system, 24 also known as the mononuclear phagocyte system. The reticuloendothelial system holds important immune functions and is located in reticular connective tissues of the spleen, lymph nodes, bone marrow, and liver.…”

Section: Discussionmentioning

confidence: 99%

In vivo assessment of bone marrow toxicity by gold nanoparticle-based bioconjugates in Crl:CD1(ICR) mice

Berce¹,

Lucan²,

Petrushev

et al. 2016

IJN

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Introduction The present study aimed at evaluating the biodistribution of Tween ® 20-gold nanoparticle (GNP) conjugates and their potential toxicity on the bone marrow before moving on to Phase I clinical trials. Materials and methods Tween ® 20-conjugated GNPs were injected intravenously for 21 days in male Crl:CD1(ICR) mice. Body weight of the mice was evaluated each day. After the sub-chronic Tween ® 20-GNPs administration, blood samples were harvested, and a full blood count was done individually. Total Au quantity from all major organs was assessed using inductively coupled plasma mass spectrometry. One femur and the sternum obtained from each animal were used for histological assessment. Results Our data showed that the Tween ® 20-GNP conjugates were found in large quantities in the bladder. Au was shown to accumulate in the hematopoietic bone tissue, with significant side effects such as leucopoiesis and megakaryopoiesis. The mice had a higher white blood cell and platelet count as opposed to the control group. This suggested that the previously described leukopenic effects of isoflurane were overridden by the leucopoietic effects of Tween ® 20-GNPs. Conclusion It was uncertain whether the mice were reactive to Au as it is a foreign substance to the tissues or whether the side effects observed were a precursor condition of a more severe hematological condition. Au was found to be hepatotoxic, urging the need for further studies in order to achieve better in vivo compliance and exploit the immense potential of GNPs in cancer pharmacology.

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Development of gatifloxacin-loaded cationic polymeric nanoparticles for ocular drug delivery

Cited by 51 publications

References 39 publications

Ophthalmic Drug Delivery Systems for Antibiotherapy—A Review

Ophthalmic Drug Delivery Systems for Antibiotherapy—A Review

Development of dry powder inhaler containing tadalafil-loaded PLGA nanoparticles

In vivo assessment of bone marrow toxicity by gold nanoparticle-based bioconjugates in Crl:CD1(ICR) mice

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