Development of Gelled-Oil Nanoparticles for the Encapsulation and Release of Berberine
Darren A. Makeiff,
Brad Smith,
Khalid Azyat
et al.
Abstract:In this study, a new drug carrier based on gelled-oil
nanoparticles
(GNPs) was designed and synthesized for the encapsulation and release
of the model hydrophobic drug, berberine chloride (BCl). Two compositions
with different oil phases were examined, sesame oil (SO) and cinnamaldehyde
(Cin), which were emulsified with water, stabilized with Tween 80
(Tw80), and gelled using an N-alkylated primary oxalamide low-molecular-weight
gelator (LMWG) to give stable dispersions of GNPs between 100 and
200 nm in size. … Show more
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