Development of Genital Ulcer due to Hydroxyurea Treatment in a Patient with Polycythemia Vera - A Case Report

Abstract

Genital ulcers due to Hydroxyurea treatment, is a very rare entity that requires the skills of dermatology specialists to suspect and diagnose it in early stages. We present a case of 48 years old female with history of polycythemia vera under treatment of Hydroxyurea during 10 years. She developed a painful genital ulcer in 15 days without any other manifestations. Herpetic etiology, HIV and primary syphilis were rejected. The skin biopsy specimen revealed neoangiogenesis associated with lymphoplasmocytic perivascular inflammatory infiltrate without evidence of vasculitis. There was a completely resolution of the lesions, 8 weeks after Hydroxyurea cessation. The patient was referred to the oncology service to continue her hematologic treatment.