Development of gold nanoparticle-based antigen delivery platform for vaccines against HIV-1

Lin, Feng

doi:10.31274/etd-180810-4094

Cited by 2 publications

(1 citation statement)

References 280 publications

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“…The HIV-1 Gag p17 peptide conjugated to 2-nm gold glyconanoparticles increased the proliferation of HIVspecific CD4 + and CD8 + T cells and induced the secretion of the highly functional TNF-α and IL-1β cytokines, as compared to the unconjugated peptide [105]. Also, GNPs conjugated with the gp120 and gp41 viral proteins were used as a platform for the delivery of immunogens in the preparation of an HIV-1 vaccine [106].…”

Section: Article Highlightsmentioning

confidence: 99%

Gold nanoparticles for preparation of antibodies and vaccines against infectious diseases

Дыкман

2020

Expert Review of Vaccines

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Introduction: Vaccination remains very effective in stimulating protective immune responses against infections. An important task in antibody and vaccine preparation is to choose an optimal carrier that will ensure a high immune response. Particularly promising in this regard are nanoscale particle carriers. An antigen that is adsorbed or encapsulated by nanoparticles can be used as an adjuvant to optimize the immune response during vaccination. a very popular antigen carrier used for immunization and vaccination is gold nanoparticles, with are being used to make new vaccines against viral, bacterial, and parasitic infections. Areas covered: This review summarizes what is currently known about the use of gold nanoparticles as an antigen carrier and adjuvant to prepare antibodies in vivo and design vaccines against viral, bacterial, and parasitic infections. The basic principles, recent advances, and current problems in the use of gold nanoparticles are discussed. Expert opinion: Gold nanoparticles can be used as adjuvants to increase the effectiveness of vaccines by stimulating antigen-presenting cells and ensuring controlled antigen release. Studying the characteristics of the immune response obtained from the use of gold nanoparticles as a carrier and an adjuvant will permit the particles' potential for vaccine design to be increased.

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Section: Article Highlightsmentioning

confidence: 99%