Deterministic safety analysis (DSA) is essential for nuclear power plant licensing. The conservative method followed CFR50 Appendix K, which will lead to a large margin. As one of the DSA methodologies, best estimate plus uncertainty (BEPU) generates more realistic results that can be used in the license application of nuclear power plants (NPPs). However, uncertainty evaluation of parameters is needed in BEPU. In this article, the safety regulatory focuses on the large break loss of coolant accident (LBLOCA) of an advanced PWR. The BEPU analysis is mainly performed by TRACE V5.0 patch 4 code, and the uncertainty analysis is conducted based on DAKOTA code. For correlation coefficients analysis, the sample size is enlarged reasonably. According to the results, this NPP meets the acceptance criteria effectively in LBLOCA with enough margin. By statistic assessment, the set of PCTs calculated has typical normal distribution characters. Based on BEPU, the uncertainties of parameters are studied. Additionally, the influence of sample size on the correlation of parameters is considered too. It could be seen that more samples could permit a more accurate estimation for Spearman partial correlation coefficient (abbreviated as SPCC). The conclusions of this article can provide technical support for the subsequent review of the safety analysis report and the design changes of NPPs.