Development of graft copolymer of carboxymethylcellulose and N-vinylcaprolactam towards strong antioxidant and antibacterial polymeric materials

Kumar, Ashok; Sharma, Swati; Afgan, Shere; Kumar, Rajesh; Keshari, Anand Kumar; Srivastava, Ragini

doi:10.1016/j.ijbiomac.2018.02.030

Cited by 15 publications

(5 citation statements)

References 15 publications

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“…The most studied thermo‐sensitive polymer with this property is poly (N‐vinylcaprolactam) (PNVCL). PNVCL has a LCST about 32 °C, and it shows hydrophilicity in aqueous solution at lower temperatures than its LCST and hydrophobicity in aqueous solution at higher temperatures than its LCST [27–29] . In fact, PNVCL is attractive for the pharmaceutical and biomedical applications in terms of relatively high resistance to hydrolysis which it does not produce toxic amide compounds.…”

Section: Introductionmentioning

confidence: 99%

“…PNVCL has a LCST about 32 °C, and it shows hydrophilicity in aqueous solution at lower temperatures than its LCST and hydrophobicity in aqueous solution at higher temperatures than its LCST. [27][28][29] In fact, PNVCL is attractive for the pharmaceutical and biomedical applications in terms of relatively high resistance to hydrolysis which it does not produce toxic amide compounds. Combining smart polymers with other compounds gives a better detection and analytical performance for different templates.…”

Section: Introductionmentioning

confidence: 99%

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Development of Thermo‐Sensitive and Magnetic Molecularly Imprinted Polymer for Extraction of Omeprazole in Biological and Pharmaceutical Samples Coupled by High Performance Liquid Chromatography

2023

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This work proposed the developed of thermo‐sensitive and magnetic molecularly imprinted polymer for the extraction of omeprazole from the human urine and pharmaceutical samples. The ethylene glycol dimethacrylate and N, N′‐methylenediacrylamide were used as the cross‐linkers, poly (N‐vinylcaprolactam) as a thermo‐sensitive monomer, and omeprazole as a template to create molecularly imprinted polymer. The maximum sorption capacity was achieved at a contact time of 15 min, pH=7, temperature of 25 °C, and initial concentration of 20 μg mL−1. Under these conditions, the omeprazole in human urine and pharmaceutical samples were determined by high performance liquid chromatography with ultra‐violet detection. The obtained polymer was characterized by different techniques. The equilibrium data were fitted well with Langmuir isotherm model.The limit of quantification and limit of detection were 0.24 and 0.061 μg mL−1, respectively. Relative standard deviations for inter‐day and intra‐day precisions were 1.78 % and 1.51 %, respectively. Omeprazole extraction recoveries from samples exceeded 93 %.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of Thermo‐Sensitive and Magnetic Molecularly Imprinted Polymer for Extraction of Omeprazole in Biological and Pharmaceutical Samples Coupled by High Performance Liquid Chromatography

2023

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“…The LCST also depends on the chemical composition in the case of copolymers [ 16 , 17 ]. In addition, the biocompatibility, associated with the complexation ability with other molecules and the low toxicity of PNVCL, justify its use in several applications in the medical field [ 16 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, RDRP of unconjugated monomers such as vinyl acetate (VAc), N -vinylcarbazole (NVK), N -vinylpyrrolidone (NVP) and N -vinylcaprolactam (NVCL) represents a challenge due to the high reactivity of the radical species formed during polymerization. For these types of monomers, the RAFT polymerization mediated by xanthates (dithiocarbonates) as chain transfer agents (RAFT/MADIX) is currently considered the most suitable [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Self-Assembly of Poly(N-Vinylcaprolactam)-b-Poly(ε-Caprolactone) Block Copolymers via the Combination of RAFT/MADIX and Ring-Opening Polymerizations

et al. 2020

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Well-defined amphiphilic, biocompatible and partially biodegradable, thermo-responsive poly(N-vinylcaprolactam)-b-poly(ε-caprolactone) (PNVCL-b-PCL) block copolymers were synthesized by combining reversible addition-fragmentation chain transfer (RAFT) and ring-opening polymerizations (ROP). Poly(N-vinylcaprolactam) containing xanthate and hydroxyl end groups (X–PNVCL–OH) was first synthesized by RAFT/macromolecular design by the interchange of xanthates (RAFT/MADIX) polymerization of NVCL mediated by a chain transfer agent containing a hydroxyl function. The xanthate-end group was then removed from PNVCL by a radical-induced process. Finally, the hydroxyl end-capped PNVCL homopolymer was used as a macroinitiator in the ROP of ε-caprolactone (ε-CL) to obtain PNVCL-b-PCL block copolymers. These (co)polymers were characterized by Size Exclusion Chromatography (SEC), Fourier-Transform Infrared spectroscopy (FTIR), Proton Nuclear Magnetic Resonance spectroscopy (1H NMR), UV–vis and Differential Scanning Calorimetry (DSC) measurements. The critical micelle concentration (CMC) of the block copolymers in aqueous solution measured by the fluorescence probe technique decreased with increasing the length of the hydrophobic block. However, dynamic light scattering (DLS) demonstrated that the size of the micelles increased with increasing the proportion of hydrophobic segments. The morphology observed by cryo-TEM demonstrated that the micelles have a pointed-oval-shape. UV–vis and DLS analyses showed that these block copolymers have a temperature-responsive behavior with a lower critical solution temperature (LCST) that could be tuned by varying the block copolymer composition.

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“…It is unrealistic to expect that special wound coverings will cover all the characteristics that would meet general needs for wound healing. Functional wound coverings should ensure wound healing with minimal time and cost [7]. In modern medicine, the list of wound coverings is constantly growing.…”

Section: Introductionmentioning

confidence: 99%

Development of a methodology for the study of polymer wound coatings for application characteristics

et al. 2020

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This paper reports a research methodology for characterizing wound dressings in order to assess the application properties of medical devices as a whole. Wound dressing was based on grafting polymerization of N-vinyl caprolactam and 2-hydoxyethyl acrylate on polyvinyl alcohol. The obtained copolymer was characterized by FTIR. Cross-linked films of wound dressings were obtained by radiation treatment of the copolymers. The physico-mechemical properties of wound dressings were investigated. Testing included degree of swelling, elastic modulus, tensile strength and elongation at break. The radiation doses of the reaction affected physico-mechanical properties of wound dressings. As the dose of radiation increased, the yield of gel increased, degree of swilling and tensile strength decreased. Also, the results indicated that yield of the crosslinked fraction increases, and the swelling capacity of polymer mesh decreases with increasing 2-hydroxyethyl acrylate content in the graft copolymer

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Development of graft copolymer of carboxymethylcellulose and N-vinylcaprolactam towards strong antioxidant and antibacterial polymeric materials

Cited by 15 publications

References 15 publications

Development of Thermo‐Sensitive and Magnetic Molecularly Imprinted Polymer for Extraction of Omeprazole in Biological and Pharmaceutical Samples Coupled by High Performance Liquid Chromatography

Development of Thermo‐Sensitive and Magnetic Molecularly Imprinted Polymer for Extraction of Omeprazole in Biological and Pharmaceutical Samples Coupled by High Performance Liquid Chromatography

Synthesis and Self-Assembly of Poly(N-Vinylcaprolactam)-b-Poly(ε-Caprolactone) Block Copolymers via the Combination of RAFT/MADIX and Ring-Opening Polymerizations

Development of a methodology for the study of polymer wound coatings for application characteristics

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