Development of Granule Cells of the Rat Olfactory Bulb: An Autoradiographic and Electron Microscopic Study.

Yokota, Shizuko; Kakuta, Sachiko; Ishikawa, Y.

doi:10.1679/aohc.56.27

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Nmda Receptor-dependent Cell Survival In the Olfactory Bulb1

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“…The TUNEL-staining results seen in the SEL [see Fig. 2(C)] are interesting, because the layer primarily contains neuroblasts migrating into the bulb (Altman, 1969;Kishi, 1987;Frazier-Cierpial and Brunjes, 1989;Kishi et al, 1990;Luskin, 1993;Yokota et al, 1993;Lois and Alvarez-Buylla, 1994;Craig et al, 1999). Intriguingly, NMDA receptors have been found on immature migrating cortical neurons (Lo-Turco et al, 1991), and evidence has implicated a role for NMDA receptor activation in promoting migration (Komuro and Rakic, 1993;Behar et al, 1999).…”

Section: Nmda Receptor-dependent Cell Survival In the Olfactory Bulbmentioning

confidence: 95%