Development of Green Spectrophotometric Method for Determination of Metoclopramide Hydrochloride

Abstract

A simple, sensitive and green spectrophotometric method for the determination of metoclopramide hydrochloride (MTC) was developed. The method was based on the reaction of MTC with p-dimethylaminobenzaldehyde (DAB) in acidic aqueous medium (pH 2) in the presence of anionic surfactant sodium dodecyl sulfate (SDS) to give a yellow colored Schiff's base with a maximum absorbance at 452 nm. Obedience to Beer's law is achieved in the concentration range 0.2-18.0 µg mL -1 (5.6×10 -7 -5.1×10 -5 mol L -1 ), with relative error about 1%, relative standard deviation of less than 0.8% and molar absorptivity 3.02×10 4 L mol -1 cm -1 . The effect of the presence of some common pharmaceutical additives was investigated. The developed procedure was successfully applied to the determination of the drug in pharmaceutical formulations.

A green approach for metoclopramide quantification in pharmaceutical products. New HPLC and spectrophotometric methods

“…The physicochemical properties of Metoclopramide Analytical methods previously published for the quantification of metoclopramide in bulk [13,14,15], pharmaceutical dosage forms [16,17,18], and biological fluids were scanned in the literatüre [19,20,21]. Spectrophotometric [22,23,24], high-performance liquid chromatographic [25,26,27], and liquid chromatographic coupled with tandem mass spectrometry (LC-MS/MS) [28] methods were reported for determination of metoclopramide in pharmaceutical dosage forms and biological fluids were developed.…”

A green approach for metoclopramide quantification in pharmaceutical products: new HPLC and spectrophotometric methods

“…Analytical methods previously published for the quantification of metoclopramide in bulk 13 – 15 , pharmaceutical dosage forms 16 – 18 , and biological fluids were scanned in the literatüre 19 – 21 . Spectrophotometric 22 – 24 , high-performance liquid chromatographic 25 – 27 , and liquid chromatographic coupled with tandem mass spectrometry (LC–MS/MS) 28 methods were reported for determination of metoclopramide in pharmaceutical dosage forms and biological fluids were developed.…”

Novel Green Method for the Spectrophotometric Determination of Metoclopramide Hydrochloride in Pharmaceutical Formulations

“…Oral forms of the drug are rapidly absorbed in the gastrointestinal tract, therefore they are not suitable for administration to children or elderly patients after surgery, as vomiting is often performed before absorption in the gastrointestinal tract (2). Taking the medicine causes some side effects, including dry mouth, insomnia, and changes in arterial blood pressure (3).…”

“…A survey of the literature reported that metoclopramide hydrochloride was estimated under optimal conditions by different spectrophotometric methods and using various chemical reagents, such as: azo-dye coupling (3)(4)(5)(6)(7)(8)(9)(10)(11), oxidative coupling (12)(13)(14), Schiff base Reaction (15), and charge transfer complex (16). A number of researchers were able to estimate (MCP.H) by using other spectrophotometric methods such as UV, colored ion-pair complex, oxidation, reduction reaction and nucleophilic substitution reaction, in the presence of chemical reagents and under various optimal condition (17)(18)(19)(20), diverse HPLC methods (21)(22)(23)(24)(25), FIuorescent analysis (26), and Glassy carbon electrode (GCE) were also used (27).…”