Development of head and neck pathology in Europe

Hellquist, Henrik B.; Agaimy, Abbas; Stenman, Göran; Franchi, Alessandro; Nadal, Alfons; Skálová, Alena; Leivo, Ilmo; Zidar, Nina; Simpson, Roderick H.W.; Slootweg, Pieter J.; Hernández-Prera, Juan C.; Ferlito, Alfio

doi:10.1007/s00428-022-03275-x

Cited by 6 publications

(4 citation statements)

References 161 publications

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“…We rather believe that the prime driver of the rising number of specimens is increasing demand for the specific competence and experience of dedicated ophthalmic pathologists among ophthalmologists and fellow pathologists. This would be in line with the general development in medicine with increasing subspecialization and complexity to the point were few generalists remain [ 21 , 22 ].…”

Section: Discussionmentioning

confidence: 74%

“…Further, the availability of additional data such as patient age, sex, and geographical origin allows for important analyses of some characteristics, trends, and possible confounders. Swedish healthcare has a similar organization as the other Nordic countries, with similar life expectancy and burden of disease, and in the light of a similar development over time in other subspecialities in the western world, we think our results give a fair representation of an increasing demand of our subspeciality [21,22,[27][28][29][30].…”

Section: Discussionmentioning

confidence: 96%

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Increasing demand for ophthalmic pathology: time trends in a laboratory with nationwide coverage

et al. 2023

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Purpose To report the time trends in basic patient characteristics and the number of specimens received at a national referral center for ophthalmic pathology. Methods Data on patient sex, age at surgical resection and geographical location of the referring unit were obtained for all specimens received at the St. Erik Ophthalmic Pathology laboratory, Stockholm, Sweden, between January 1st, 1959, and December 31st, 2021. Results A total of 33 057 specimens had been received, of which 14 560 (44%) came from men and 18 477 (56%) from women (for 20 patients, the sex was not specified). The average annual percent change (AAPC) in the number specimens received was + 10.5%, whereas the Swedish population increased with 0.5% per year. Patients became older throughout the period, with an average yearly increase of patient age at surgery of 0.3 years (AAPC 0.2%). Overall, women were three years older than men at surgery (59.4 versus 56.4 years, P < 0.0001) The number of specimens increased with patient age from the first to the 8th decade, after which it decreased to zero in the 11th decade. The largest portion of patients had undergone their surgery in one of the hospitals or clinics in the capital region, with four of the five largest sources corresponding to the most populous counties in the country. Conclusions During six decades, the growth in number of specimens sent to our national referral center for ophthalmic pathology has greatly outpaced the growth of the population, indicating an increasing demand for subspecialized services. Throughout the period, patients have become older, and a higher number of specimens have been submitted from female patients.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 96%

Increasing demand for ophthalmic pathology: time trends in a laboratory with nationwide coverage

et al. 2023

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“…The great variety of different histotypes occurring primarily in the sinonasal tract together with the presence of limited biopsy material, pose significant diagnostic difficulties for the pathologist requiring specific knowledge and availability of immunohistochemical and molecular techniques. In recent years, the increasingly frequent participation in work groups has favored the development of a pathologists network with specific skills in sinonasal region area as well ( 13 ). For correct diagnostic identification, several biomarkers have been identified, including: synaptophysin, chromogranin, S-100, CD-56 and neuron-specific haemolysis (NSE).…”

Section: Diagnosismentioning

confidence: 99%

Olfactory neuroblastoma: diagnosis, management, and current treatment options

Tosoni,

Di Nunno,

Gatto

et al. 2023

Front. Oncol.

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Olfactory neuroblastoma (ONB) is a rare neoplasm originating from the olfactory neuroepithelium representing 3-6% of tumors of the sinonasal tract. ONB require multi-disciplinary care. Historically, the gold standard surgical procedure for ONB has been open craniofacial resection. In the last years, endoscopic endonasal approaches have been largely introduced with lower complication rates, shorter hospital stay, and similar clinical outcome. Radiotherapy plays an important role in the management of ONB, however there are not generally accepted recommendations for its application. Although there is agreement that multimodal therapy is needed, the optimal use of chemotherapy is still unknown. The rarity of the disease, makes difficult to draw definitive conclusions about the role of systemic treatment in induction and concomitant setting.

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“…In addition, this method is not acceptable to many patients due to its invasiveness, especially when the lesion is present in a seemingly "normal" or asymptomatic oral mucosa. Furthermore, invasive serial biopsies have limited reproducibility when performing long-term monitoring of patients with suspected oral lesions 13 . Other than that, it is time-consuming, operator- and pathologist-dependent, and used primarily in hospitals.…”

Section: Introductionmentioning

confidence: 99%

DNA Image Cytometry for Screening the Carcinogenetic Risk of Oral Potential Malignant Disorders

Li,

Gao

et al. 2024

J. Cancer

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Background: Oral Submucosal Fibrosis (OSF) and Oral Leukoplakia (OLK) are well-known oral potentially malignant disorders, and cases of Oral Submucosal Fibrosis concomitant Oral Leukoplakia (OSF+OLK) are now being reported clinically. DNA image cytometry is an objective and non-invasive method for monitoring the risk of precancerous lesions in the oral cavity. Methods: A total of 111 patients with clinically characterized oral mucosal lesions underwent simultaneous and independent histopathological and DNA imaging cytometry assessments. Clinical data were also collected for each patient. Results: The frequency of DNA content abnormality was higher in the tongue than in other oral sites (P = 0.003) for OLK. The frequency of DNA content abnormality was higher in the tongue than in other oral sites (P = 0.035) for OSF+OLK. The differences of DNA content abnormality in age, sex, dietary habit, smoking, and alcohol intake were not observed in OLK and OSF+OLK. The study indicates an association between DNA content abnormality and pathological examination in OSF+OLK ( χ 2 test, P = 0.007). OLK showed higher sensitivity and specificity than OSF, while the sensitivity and specificity of OSF+OLK are higher than OLK only and OSF only. Conclusion: DNA image cytometry can be utilized as an adjunctive device for the initial detection of oral potentially malignant disorders that require further clinical management.

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Development of head and neck pathology in Europe

Cited by 6 publications

References 161 publications

Increasing demand for ophthalmic pathology: time trends in a laboratory with nationwide coverage

Increasing demand for ophthalmic pathology: time trends in a laboratory with nationwide coverage

Olfactory neuroblastoma: diagnosis, management, and current treatment options

DNA Image Cytometry for Screening the Carcinogenetic Risk of Oral Potential Malignant Disorders

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